ID E9ELZ2_METRA Unreviewed; 789 AA.
AC E9ELZ2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Transferrin receptor-like, dimerization domain protein {ECO:0000313|EMBL:EFZ03577.1};
GN ORFNames=MAA_00651 {ECO:0000313|EMBL:EFZ03577.1};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFZ03577.1, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFZ03577.1, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFZ03577.1, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ03577.1}.
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DR EMBL; ADNJ02000007; EFZ03577.1; -; Genomic_DNA.
DR RefSeq; XP_007816840.1; XM_007818649.1.
DR AlphaFoldDB; E9ELZ2; -.
DR GeneID; 19254937; -.
DR KEGG; maj:MAA_00651; -.
DR HOGENOM; CLU_005688_2_0_1; -.
DR OrthoDB; 67337at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000313|EMBL:EFZ03577.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..272
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 389..574
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 664..788
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 249..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 87020 MW; FAEF778A505864DD CRC64;
MANESTPLIQ TVRVAPPRRR YRHDTCRRFC TIACTCVLVL GFASFLTHVF LIWPYHHHHG
RHSHYSHSHQ QGKRLSHQEV QKILLETPTA DHAEEWSRYY TSGPHLAGKN FSQADWTREK
WQSWGVDASI AEYDVYINYP LEHSLSLLKK SKKDDSWTVT FDASLTEAVL DEDPTTALDT
RVPTFHGYSA SGNVTGQFVY VNYGTYQDYQ DLVDAGINLK GKIAIARYGG IFRGLKVKRA
QELGMVGTII YSDPGDDGDK TEANGYEQYP KGPARHESSV QRGSVQFLSI RPGDPTTPGY
PSKPGVPRAP ADDSTPSIPS IPISYVDALP ILKALNGHGP KASDLSDHWT RNLGLGYKGI
DYNVGPSPEH VLLNLHNEQE YVTTPQWDVI GVVNGTIPNE VIVVGNHRDA WIAGGAGDPN
SGSAVLNEVV RSVGKAVEAG WKPLRTIVFG SWDGEEYGLI GSTEWVEEYL PWLSDANVAY
INVDVAASGS SFEASAAPLL NQVLRDATHK VPSPNQTVPG QSVGDVWDGR ISTMGSGSDF
TAFQDFAGVP SIDMGFKTGS NGPVYHYHSN YDSFHWMHEY GDPGFKYHLA MSRVLGVLLS
ELADTIVIPF GATEYADALG AYLDQVEAKL NSNEDPATDE AMFAMRGSAL SKDAKGSADA
FEASLRKIRA SLSKLRTKAV GLDERAAWAN KKLRDGIPWW NIIGKIKLWT TIAKVNVQYK
FFERHFLFEG GLDKRSWFKH VVFAPGLWTG YSGAVYPGLV ESIDAKDYIN GLKWAGIIDR
CVNKAAESI
//
