ID E9ETP2_METRA Unreviewed; 1170 AA.
AC E9ETP2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=MAA_03391 {ECO:0000313|EMBL:EFZ00795.1};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFZ00795.1, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFZ00795.1, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFZ00795.1, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ00795.1}.
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DR EMBL; ADNJ02000003; EFZ00795.1; -; Genomic_DNA.
DR RefSeq; XP_007819580.1; XM_007821389.1.
DR AlphaFoldDB; E9ETP2; -.
DR GeneID; 19257677; -.
DR KEGG; maj:MAA_03391; -.
DR HOGENOM; CLU_007956_0_0_1; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 75..329
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 688..1077
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1170 AA; 128887 MW; 951B384EAEBEA781 CRC64;
MADFRQLALD FVLEDNKAKS VRFAQKAAKE IEAAAPNSNP VARWVESVQP WMPGSNDDDV
MRDAGDTPDW TARSRAALEF LSLTLHYLKP EALKPSQVNL LVAFFGAMFD VDHKAGILPS
ATALSRIIAM KSFHPNSGRD IILKVCTLKE DFPRQISKTR LAVYELLRSL VSNPEVAKDL
QQRDGKDTAF MKDLLHLCQT ERDPDCLMVW FDILRLFLSE YSPSKEILEE IYGTFKAYFP
ITLPRTAQSG VTPEELKLQL RKCFSSTHRL ASLSLPFLIG KLDQGDGVTV NVKVDVLRTI
RACLEEYKDP TESITPYTNR IWTSLKYEVR NGEIEDTIWA TLEVLKALTT RLAGDDLRDY
TLTVTRDCVV DLATPMYTTA AGRLLVSVLS ANPSAFVLMV APAVTHIKEN LRHPKSPTHS
QDLLKILRII LETRLLLTDV EMSEHDRNDF AAVDGVFKTL YADVYKGPLE LLAKPGASDE
DFKLSTEAAQ GVGALIGQRE VKSLASDAGH KTSDLALLLP ISTCAESCET LFNISTQQWD
ERARRIGADE LVNESVKALQ RIIQAYPGGF PSIVAKTSSI LRQSIANLTH DSLDTIQSLG
PLLAYIGCSS LSASLELSLG QFVQVVRTIE LELSAAIDQA TSPIIWCFLV AGIHSTVRYF
NEACLEKDAK ASAVEEGTLS LDQIVVKYPQ LSSTSAFSEP AVPTVQSTLT SVNEARTDAL
LIGLHIVGSL YRRATQPTET GGQLAKSSDF NGSEPHQELR YLSLLSELAG FIVHELNESQ
QASLEAEKYA LNLFRGEEVN VSAPSSWTWL TSGYLGILSL GILESVRPSR IAKFYETGVA
QQILTEGTAT GSSVGEVALR PVRRSILAIL ANKHNIETLD SVMANVATSL QDALQKTRAD
SANGSLATNL ETCFSIFSLI GGLFRRYSGN KIQPLIQLLR TAPNDVQSGY QLGRGLEIIV
VPQRFLTKEN FAVVRLLWLQ KIYIELIKPM LEVALGKDSS ITDPVIRTNF SISVLLMVKH
LDFSIYEQDA DKILRIAIAI AQNLGIGPDG MAALQVIKDI LVEASEQAED HIRSLIKICA
SIFANRQQSA DRPDWLPAEY GDATPSLEVQ AGCGKIALEI VGGLPRMFES RHLLAYEPQV
QRDLSTACGH RVRELRSTAR LARGAWANVK
//
