ID E9EWG4_METRA Unreviewed; 1103 AA.
AC E9EWG4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 2.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Single-stranded nucleic acid binding R3H {ECO:0000313|EMBL:EFZ00586.2};
GN ORFNames=MAA_04363 {ECO:0000313|EMBL:EFZ00586.2};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFZ00586.2, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFZ00586.2, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFZ00586.2, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ00586.2}.
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DR EMBL; ADNJ02000005; EFZ00586.2; -; Genomic_DNA.
DR RefSeq; XP_007820552.2; XM_007822361.2.
DR AlphaFoldDB; E9EWG4; -.
DR GeneID; 19258649; -.
DR KEGG; maj:MAA_04363; -.
DR HOGENOM; CLU_005714_2_0_1; -.
DR OrthoDB; 1412at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06008; NF-X1-zinc-finger; 5.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR000967; Znf_NFX1.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01422; zf-NF-X1; 7.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00438; ZnF_NFX; 8.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 838..901
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 1..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 121212 MW; 26F645E11FAFD967 CRC64;
MPEAEGSQAQ NQSQRPNRGR NHGHRRGRGG KTRQLVDGSR SGGASAPSQS ETSQSQTGST
ATQRQIQASS EAPARSIPDG SNSNQRGRDR RPRGPRQVGR GSARHDAPRS FAHRSFGGHL
TGVSGEAGDS AVSAAPSLSA DAPEFVPGKP LVTRSKPTKP KTFAKPQVRL PKSTAEDLGT
RIHEDIRNFN YECAICTDDV VRTSHVWSCT LCWTVVHLKC VRKWYDNQKK QTDLQPSEPR
QVFTWRCPGC NSKLSDDPGS YHCWCGKDIN PHPAPSSLPP HSCGQTCSKP RPTCPHPCPL
QCHAGPCPPC GLMGPTQSCF CGKNESRKLC RETDYENGWS CQETCGDLLP CGEHFCSKPC
HSGLCGDCDM TVDAKCYCGR VEKQMPCFER EEPQMSYHIA DQSWFDGTFT CDRLCERSFD
CGIHKCSESC HPQEEQPAHC PYSPESVTHC PCGKTPLGEL LKNARVSCED PIPHCEEPCH
KKLPCGHLCA SKCHTGDCGF CNETIEVACI CGRTRTRSVC HQGNVQSPMC MRICQANLSC
GRHKCGEHCC AGEKKAAERQ AARRKHKLPS EVTSIEAEHI CIKTCGRQLK CGSHECQQIC
HRGPCANCPE AIFTEISCDC GRTVLHPPQP CGTRPPDCRF NCLRRPSCGH PSVEHNCHAG
DISCPKCPFL VEKWCACGKE KIHSQPCHLQ EAHCGRVCGK KLKCGLHSCK KLCHRPGECE
DANLSGKRCE QACGKTKLFC EHPCQNTCHG QTACNESSAC TAKAVISCPC GVRTQEVKCL
ASSSNATPSR IEIKCDDECL RLERNRRLAA ALNIDPTSHQ NDHIPYSDTT LRLFKENTSW
AETQEREFRV FAKSPNEVRL RYKPMSTTYR QFLHVLAEDY GLESRSEDIE PYRYVVVFKG
TRFVSAPSKT LSQCIKIRAA QAADAASAAA SRAPSPPLTA QDPFNGFLLT SPRFGLTIDD
VKTALNSDLS TQPSVHFEIS FLPSDEVLLR ATTSYSSFLS PPALEQVLIS LKPRLARTIQ
GSDVAGKVFL CHVDSAGHVA RRDDVSKTDA SGWSAVAGRA AAKLDTAVEE APRTTGRRLV
GLRKKKIERE RSWTHELDGD VEC
//
