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Database: UniProt
Entry: E9EYW0_METRA
LinkDB: E9EYW0_METRA
Original site: E9EYW0_METRA 
ID   E9EYW0_METRA            Unreviewed;       612 AA.
AC   E9EYW0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   23-MAY-2018, entry version 36.
DE   RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN   ORFNames=MAA_05209 {ECO:0000313|EMBL:EFY99151.1};
OS   Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS   anisopliae (strain ARSEF 23)).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY99151.1, ECO:0000313|Proteomes:UP000002498};
RN   [1] {ECO:0000313|EMBL:EFY99151.1, ECO:0000313|Proteomes:UP000002498}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z.,
RA   Hu X., Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W.,
RA   Wang S., Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y.,
RA   Feng M.G., Xia Y., Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2] {ECO:0000313|EMBL:EFY99151.1, ECO:0000313|Proteomes:UP000002498}
RP   GENOME REANNOTATION.
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and
RT   host adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003426}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFY99151.1}.
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DR   EMBL; ADNJ02000002; EFY99151.1; -; Genomic_DNA.
DR   RefSeq; XP_007821398.1; XM_007823207.1.
DR   EnsemblFungi; EFY99151; EFY99151; MAA_05209.
DR   GeneID; 19259495; -.
DR   KEGG; maj:MAA_05209; -.
DR   KO; K00027; -.
DR   OrthoDB; EOG092C16UJ; -.
DR   Proteomes; UP000002498; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006108; P:malate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006090; P:pyruvate metabolic process; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002498};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003426};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002498}.
FT   DOMAIN       90    271       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      281    542       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    113    113       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    185    185       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       256    256       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       257    257       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       280    280       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   612 AA;  67244 MW;  45078F8FD7DE83B5 CRC64;
     MVSRKDAQFD HLTLNTRGPI PCALQGQAVL NTPYFNKGSA FPAHERRVFN LTGLLPQNVQ
     TLQEQAKRAH EQYLSQTDDL AKNTFLASLK EQNEVLYYKL LQDNIKAMFS VVYTPTEGDA
     IQNYSRLFRR PEGCFLNIND TERVFHDLAM WGEADDIDYI VVTDGEEILG IGDQGVGGVL
     ISVAKLVLAT LCAGVHPNRC LPVVLDCGTD NEHLLRDELY LGLRKKRVRG ERYDEFVDSF
     VRAARTLYPR AYIHFEDFGL LNARRILDTY RPKMACFNDD VQGTGCVTLA AIMAGLHVSG
     QKLADLKMVV FGAGSAGIGI ADQVRDAIAA EGNTSPEEAS RQIWLIDRPG LLTTETKVSD
     AQRPFAKNAA DWTGQRTDLL GVIQAVRPNV LVGTSTVPGA FTQEIVTEMA KHTARPIIFP
     LSNPTRLHEQ TPENLLQWTR GKALVATGSP FDPVQGPWGA GGEQVTMEIA ECNNSVVFPG
     IGLGCILSRA RLLTDKMLVA AVQAVAAMSP ALRDPTAPLL PDVGDVRNVS LQVAMGIVKA
     AVQEGVATED GIPSDDHQLR EWIRVQMWEP RYRDLEKVEM EGAGRTARGE LRKAGTVDRM
     SDMSAYGAMV QQ
//
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