ID E9F2I9_METRA Unreviewed; 1907 AA.
AC E9F2I9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 2.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Vacuolar membrane-associated protein IML1 {ECO:0000256|ARBA:ARBA00018529};
DE AltName: Full=Vacuolar membrane-associated protein iml1 {ECO:0000256|ARBA:ARBA00021881};
GN ORFNames=MAA_06387 {ECO:0000313|EMBL:EFY98278.2};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY98278.2, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFY98278.2, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFY98278.2, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|ARBA:ARBA00004148};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004148}.
CC -!- SIMILARITY: Belongs to the IML1 family.
CC {ECO:0000256|ARBA:ARBA00005643}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY98278.2}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADNJ02000006; EFY98278.2; -; Genomic_DNA.
DR RefSeq; XP_007822576.2; XM_007824385.2.
DR GeneID; 19260673; -.
DR KEGG; maj:MAA_06387; -.
DR HOGENOM; CLU_000935_0_0_1; -.
DR OrthoDB; 946033at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04449; DEP_DEPDC5-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR048255; IML1_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
FT DOMAIN 1331..1437
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1907 AA; 213765 MW; EE9E40D6F85F9F43 CRC64;
MSRYAGPMPP VPRRGPRWSH IHHPGTVSFD LGSTESPSSP GSTSTHSTIR EDKRRKTERH
CTISVNDGYS KDEVLLNLDH LGGDIKPGAL MALIPLKGDS KNATCGYGSV SKQPHEHLDS
ARAASGTHSD HDHGAGHTYI FVAKDMSKEM KARHPDTEVH VAKHIADAFF MKKGCHVLLR
PVNQHHPAVE ATHVEMSFKD QYLSRADMWR LAAGELTQRT VYKGQSLFFM GTIKAQVTAV
YVNGHTVHSA FFGKDTRPIF RSESAKYVLF IQMAREMWDF DSEASGEIMF NKVVNGFLPA
LFKRWAVLKV KHLVSIVLFA RVEYDTGISA DLATSSLLDD YYTGMQPYGN RRPYKDFYRV
VVSEMASGEW TTILYQLKRE FNFFRRDITL HHQKVRAFGH RPSDEDGAKD GISSPAKAES
SLSIHGNVLE AINMAASQFS HDYIDRDLTR TGISIAVITP GPGVFEVDYE TLRRTTESLV
GSGIGIDLIC MASMPLHSVP LFKYRNPQFS EDAHHSQGHA LSRSFHSRDS TPSHPTPVIG
SYQSMSGSFS PTKAYSLAGR IETLALTGAN EEFCYALPQW LHVSFWTGAA EESLSYAGIA
LTVSNKVEQE DKDWFKVRCR MYDLQMRSVL DANEIETAPL QSDSSYPSHL VQASAIAKKR
PDRPGDTIYI PNKQAPETLF DHVYGFQKFV PEKLVRPGEK SICKHLQEYD DAKARLPRAR
PYHQHQPSRN KTEFEDVARR QLNDDTSALG TSLPERRAST YLQPSHMQAS RKFSLTTTEV
EKPVLSAPKP SPEPPPSTAI FKKAPSIKQP KFMRQISLGQ RGFGIAAPKV AAAELKIETV
GAAAVSSNLR PPSSAHSFSD LRPSTPQTIT SRSSSASAQR QKYETADSTA DGVPSTPSIP
ISRDSFNRPG TAVSQVKSPS VLPVAASARR ERRPEDSDVR FSNALRAEDA QKVYTSKLRA
GVVPELPSTL SPTTAITPWL TLLNPSNPER HKIDDTILYS RWQHVFPRTS DMKVQKWKTL
CCPAAVPLTT EYFPAKAQFD AEYQRHPYNI DQNLDDDVVD EPKSRKDFIK ELISMRFSQG
FQVIVGPSVA RAFGQKVIKV ADVFARDQPL DDGTSVFMSV GNTIHQLSCV NGSEVEVNIY
LRKPTDVTAE SQRYPSAYRP AIRTIFDTEY ETRSFDILTP KMDRNWNTID SYLAGHYDQM
MDSLRFWRAR FVLIPLGPKH PLIQRVQTSD NPEELRIEGI KRLCQIWQKH RYMAPSDRRF
QPTAKRRSPL DIVYKTEDPS VVIAAEVETL PILENLEGPH RKGGLVTRKE RFQKGNLNLA
TLAEAMQQPV ENGGVPLRNR RWHLRLHNAA FIGSDMTTWI LDNFEDLDSR EEAEELGNAL
MVPNEPKHKD KDKSKDKEKD KEKEHAEPKS EKDRGLFVHV ERRHNFRDGN YFYQIAPEFA
KPQPGWFSSR RRDVTSPAAP GSDGGSMDSP RSNMPRPLVP NDPKSPASLG PAIGSSQLLK
NRPKVVLSKM IKYDIDPRKR SYRPERIDLH YDRLHNPDNC YHIRIGWMNT TSKLVEDTIE
SWEREASQYG LRLVEVPINE ACRITETNPF RKPYRIRLAI RPPLERPETY YDPNSLDLQA
GPSKNFYQTV ILKNFDFVLD MEAASNFPSD VDVRYSWGKP DFSYTQYIHR SGAVLAQITD
EGDFLVLANR LYNKRTSMAR DKELRSQVHS EQQQQQQQQQ QQQQPQPLPP LNTNTRAMAQ
IAPYVSGHPT TNLPESAAPL ASPQVRPTFY HFSPASRPID ASIYGSKISY PAGRSEPEVL
KTELEAFCLN EVALTAFYKD ILDKGQRPHG TPASTATTQS IAGLEPVPEA SIPSLGLGPG
ILGGDGAGGV GNGHSAAMAS MRMSSPMAFL RRGSVQYDGM GLGSKGK
//
