ID E9F513_METRA Unreviewed; 1315 AA.
AC E9F513;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN ORFNames=MAA_07362 {ECO:0000313|EMBL:EFY97066.1};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY97066.1, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFY97066.1, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFY97066.1, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY97066.1}.
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DR EMBL; ADNJ02000003; EFY97066.1; -; Genomic_DNA.
DR RefSeq; XP_007823551.1; XM_007825360.1.
DR GeneID; 19261648; -.
DR KEGG; maj:MAA_07362; -.
DR HOGENOM; CLU_001366_0_2_1; -.
DR OrthoDB; 5477883at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR CDD; cd00590; RRM_SF; 1.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1315 AA; 150091 MW; B5195EEDD4F9111D CRC64;
MPEPRQQNPL SHGRGSGGRI QELRTTSIPS SDSQNEWRTR PYVIIRVNNL PVDISAEYIW
RWFASEGNIL WIDLFDPKSV NGTMSAKIRF EPPPRLNIWD LGPVRVDHPD TRQYPNGLRL
MVSLDERPPV NTLKSPRYPD KIILKLNSLG FGSMLSPSLM RVMKTINSPG GIPLELNVRS
NIMSVLFTTV SHINNRESSK ECQVRFKISN IKTILESTAD NENELRHWVI SLPYPPEYFE
KVDNIMDTFQ GNPQKWSLSD TWQRATDISP VSNDAHPISI HNEAQFDDYI DIGRWTTFRL
SFDPEKAENS ASYLHLQAAF YDLNVLVRPG CVFDTKTDAP SLWDYIEHPL AVTASQPSAL
LSMPQKIHLP FEVRYQLEVC ISRGVLNEYA IGIDFLQELN NLQTMDATHR LEYLVDQNEI
LFDPMKLFSM EDATAFVPAA RIPHYCTYVR KASITATTIR FNSPTVETSN RVVRKYSHLQ
DRFLRVQFVE ESELVRLGKT KYKNDKIWKR VERALSQGIR IGDRQYEFLA FGSSQLRQSS
AYFFCPTGHL SCEDIRAWMG QFDHIKCVAK YAARIGQCFS TTRDIKGIWV PDIKYIDDIQ
RNDQCFTDGV GLISKFLSQL IMEEMTLDIF DKPTAFQFRM GGCKGVLAVW PQAQGMEVHI
RNSQEKFKSD FQGLEIVRCA ARSTATLNRQ TITILESLGV PKKMFMALLK EQISWYENAA
KDTSEAIKLL TKFVDENQSS LVLAELLKAG FMTDNVREPF TLNTFNLWLS WSFRLLREKT
RIHVPKSAFV LGCVDESGSL RGHSIETEGC SDQLNENKLP QIFLQLTDPS HEGKTNIIQG
KCIVGRNPSL HPGDIRVVQA VNNPKLRHLK DVIVFPSKGD RPVPAMLSGG DLDGDDFFII
WDDRLIPKEW NHKPMDYQAP NPRQLDRDVT VDDLREFFVN YMKNDNLGLI AVAHLAFADM
HGPKSQICLR LAELHSQAVD YAKTGEPAEF GHKMQPERWP HFMEKKSTYR SNKALGALFD
EVAKHTFQFR PEWEHPFDKR ILERYEFDMS TLTTAREIKA QYDSAIRRLM VQYHVETEYE
LYTGWVMSNT SISSNYKRQE DLGLEFDVVK QRFREQCCNV AGGSEAPQLD KFVAAMYKVT
EEQVNKARNG GDDEPVGHQA ETDSGEEPRP NVPFISFPWI FHWVMIRLAM GDKYKPGASV
LAAARRTCLF NRHSHLQSQS ETSSVAATET LSKVDTNKDT KQRIISDGQK TQETVGRQTT
NMKENNPVQS SDAITTGDNA LQQDDEDDDT KEDISNYAIS GESGEAAFLR LAALG
//
