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Database: UniProt
Entry: E9F6M6_METRA
LinkDB: E9F6M6_METRA
Original site: E9F6M6_METRA 
ID   E9F6M6_METRA            Unreviewed;      2627 AA.
AC   E9F6M6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   23-MAY-2018, entry version 49.
DE   SubName: Full=Polyketide synthase {ECO:0000313|EMBL:EFY96642.1};
GN   ORFNames=MAA_07925 {ECO:0000313|EMBL:EFY96642.1};
OS   Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS   anisopliae (strain ARSEF 23)).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY96642.1, ECO:0000313|Proteomes:UP000002498};
RN   [1] {ECO:0000313|EMBL:EFY96642.1, ECO:0000313|Proteomes:UP000002498}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z.,
RA   Hu X., Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W.,
RA   Wang S., Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y.,
RA   Feng M.G., Xia Y., Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2] {ECO:0000313|EMBL:EFY96642.1, ECO:0000313|Proteomes:UP000002498}
RP   GENOME REANNOTATION.
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and
RT   host adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFY96642.1}.
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DR   EMBL; ADNJ02000002; EFY96642.1; -; Genomic_DNA.
DR   RefSeq; XP_007824114.1; XM_007825923.1.
DR   EnsemblFungi; EFY96642; EFY96642; MAA_07925.
DR   GeneID; 19262211; -.
DR   KEGG; maj:MAA_07925; -.
DR   OrthoDB; EOG092C00JV; -.
DR   Proteomes; UP000002498; Unassembled WGS sequence.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   Gene3D; 3.40.366.10; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR013120; Male_sterile_NAD-bd.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR032088; SAT.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF16073; SAT; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52151; SSF52151; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   SUPFAM; SSF53901; SSF53901; 1.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002498};
KW   Phosphopantetheine {ECO:0000256|PROSITE-ProRule:PRU00258};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002498};
KW   Transferase {ECO:0000256|SAAS:SAAS00555074}.
FT   DOMAIN     1678   1755       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES    1715   1715       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   2627 AA;  286913 MW;  E7D9D3795E08A629 CRC64;
     MHSDPRLASP NGALNVFLFG SLPLSFDHSE FHRIQSTVRG DESVSWILKV VSELPELWQP
     ISAALGVPSE RVVEGYMQLV DLKNAFNSGA ALTTPYPLPN KLLVPLATID QLIQYMSFHK
     TAYAGQDDEA DWVSRASAKG ETLGFCTGLL SSAAVSSSKS ASDFERYGSS AIRLAVAVGA
     VADMDAKASA QSPQPTRCLG TEWNSDSKLA DLRKIIDSRD DTYISVNYDY NRATVTTSLA
     AMAQVQQNMR SAGLPASEIG LRGRYHSEEH ADALSALLRF CDGRPEFQFR DCSDLVMKSR
     SNTGGQYFTS GPLHHHVLRS IILEPPSWYE TIKTLESEVL SQDEKASIVA FGPERPLPPS
     LSPSLSSRCI HVSDSRNAPA KSTRQGRSGG VYPDTDIAVV GMSCKVAGAD DLEEFWEVLS
     SGKSQHKEVS SERFTFETAF RDMDPKRKWF GNFIRAHDKF DNKFFKTSPR EAATTDPQQR
     QLLQVAYQAV EQSGYFHKEQ DDSSREVGCY IGLCGTDYEN NIACYPANAF CATGNLEGFA
     AGKISHYFGW TGPAFVVDTA CSSSAVAIHQ ACRAILSGEC SAALAGGTHI MTSPYRFQNL
     AGASFLSTTG QCKPFDSRAD GYCRGDGVAA IFLKKLSVAI ADGDQVLGVI AATGVQQNQN
     CTPIFVPNSP SLSDLFRNVS TKANLEPEAI TVVEAHGTGT AVGDPAEYES VRRVLGGTNR
     SNSLVLGSVK GFIGHTEPVS GVLSLIKVLL MMNKGYIPPQ ASFETINPNI KAQSSDKIVI
     PTSLRPWNAD FKAALINNYG ASGSNASMVL TQGPSKIPKP AYHESSDKKY PFWLCGLDDS
     SVRRYATALL KYISNRKASS RDAELTLRDV SFNLARKTNR SLARSSIFSV KSLGELSQAL
     SSIADNKVGF STSAPKAERP VVLCFGGQIS TFVGLDKELY DRVKILRLHL DAVDSAAKSL
     GAGSIFPDIF HREPVKDTVK LQTILFAIQY ASAKCWIDSG VKPVALVGHS FGELTALCVS
     GILTLQDCLK AVIKRATLVR DFWGAEKGAM MAIEADLDKV QDVLQKAAMS LGSSNSAPAS
     IACYNGPRSF TLAGSVESID AVAKVLESEP PKTIRSKRLN VTNSFHCSLV DNIDAQLNEC
     GLGLSFQKPT IPLEHATEQP LEEVTSSFFA KHLRSPVFFD RALKRITSKH PSCVFLEAGS
     NSTVTNMASR ALGNNGDLYF QGVNITGEPG TAWNNLVDST LSLWKEGLTM GFWSHHGSDV
     LSHEPLLLPP YQFEQAKHWM DLKAPQKTIL EVPQNNKPDE TESSLFQFAG YTDSKKQEGR
     FRINTSSKQY ERLVSGHVFA ETAAICPATV QLDFVIEAIR SLNQELASEH LQPQLHNVQC
     QLPVCVDASR TLWIDFKESA GDTRSLWKFS IVSTEASSKT DKGLSVHTTG TLRFVPTDDS
     SAELEFSRLQ RLVGSRQCLE LLNSGDVEEV LLNRSIYKIF AEIVNYTDDY RGVQKLVSRG
     NQSAAHVVRQ HDATTWLDAH LADCLCQVAG IWANCMTDCS SADMYVCNGM EHWFRNPRQS
     GNKDKSGRPA ALNVLAVHHY PSEKAILSDI FAFDAKTNDL VEVITGISYV KVSRASMSKV
     LSRLTPGLLP AAARTEPSSA MSGSILATNV DNARPENGHA PVSRTQELVT SSKAAKKSAS
     SGIASQLRKI ISELSGVEEG EIQADSALAD LGIDSLLGME LAHEVDSAFK INIPEATLME
     IVDFPGLLKV VAELLGESME PDAGEEGGHE QIASSSTSEF GDRSNSECSG FQTGVSTPAL
     SEPEVPFDLK LSHELVMQTF TAVKEKTDDR IVEHGQENYA TVAEPLQTEL CISLTLDALD
     DLGYSVRNAP AGSSITRVPH PAEHSRLVDA LYAMLDKEGK LVTVDGGRIT RTSTPCPVQS
     SQEIFQRLLS RFPDQHVADK LTFYAGSRLA DVLREKTNGI KLIFGCTEGR ELVSRFYAEW
     PLHKLLYRQL QDFVRRLAEE LKAVNGGPLK ILEMGAGTGG TTKLLLPILA EANIPVEYTF
     TDLAPSFVAA ARKTFKDYPF MKFRQHDISN PPPQDLIGTQ HLIIASNAVH ATPNLKTSTG
     NIRKALREDG MLLLVEMTGR VWWMDLVFGL FEGWWLFDDG REYVVQDERQ WERDLQSVGY
     GVVDWTDGAR PENKLERLII ASASRSTRCA SLPTPPPCVK SPSADCEFRE AAVKEYVEDL
     SKGFAESLGV GAALGGGQGA RTRRGDGKCV LVTGGTGSLG AHIVANLALR PDVREVVCLN
     RRSKVDAVLR QTQSMLDKGL SLPGEALEKL RVFETDLSKE FLGLSETDYR SLTMSVTHIV
     HNAWLMNTKW PLKRFEPQLR IMRNMVYLAR DASLAKESTE KVSFQLVSSV AAVGHWPVWS
     GEATVPEERM TIDSVLPIGY GDAKHTCEKL LDRTLHLFPG RFRVTVVRPG QIAGSSSSGY
     WNSMEHVPFL IKSSQTLGVL PDLPGHLAWA PVDAVAGTAV DILTLPDNVQ AHPVYHIDNP
     KRQSWSEMVS MLARALDIPD DKIIPFADWI HVVRSNAKQS NGPDEENPAS MLADFFEQDF
     VHMSCGAMVL GTDKACEHSV TLRSLEPVTE ALLGSYVSNW QKAGFLR
//
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