ID E9F7F7_METRA Unreviewed; 682 AA.
AC E9F7F7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Peptidase S8/S53, subtilisin/kexin/sedolisin {ECO:0000313|EMBL:EFY96294.1};
GN ORFNames=MAA_08206 {ECO:0000313|EMBL:EFY96294.1};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY96294.1, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFY96294.1, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFY96294.1, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY96294.1}.
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DR EMBL; ADNJ02000004; EFY96294.1; -; Genomic_DNA.
DR RefSeq; XP_007824395.1; XM_007826204.1.
DR AlphaFoldDB; E9F7F7; -.
DR GeneID; 19262492; -.
DR KEGG; maj:MAA_08206; -.
DR HOGENOM; CLU_449831_0_0_1; -.
DR OrthoDB; 2319096at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00306; Peptidases_S8_S53; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR PANTHER; PTHR43806:SF7; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01240};
KW Protease {ECO:0000256|PROSITE-ProRule:PRU01240};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01240}.
FT DOMAIN 398..610
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 236..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 414
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 440
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 590
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 682 AA; 76999 MW; AD6A06C0AA6C2CC2 CRC64;
MRRYEDVQAL LICWKDAIKT FQDQRTELQR VLRSPYNFGA KAIDIPSTDP EKYLEDKIRN
FREAHDKEQN LLLVYYGGHG DVLRLDGQLI IKCFDGIQHP YVEWNTRQKS FLKGSKADTL
IILDCCHSAS AIESIYCGQD NVVELLTACS IEGKAPLRGN HSLTSKLTDL LQSKELFTSG
FDTSYLYNRL VHYQKLKGQV YLGDDEDEKG VTPLRIVLLS RREQFRNLHI CRRITPDSED
EENDAEINGA TGRESEPGKQ DGQESGEAAH LSATHRSKSY SDVATNTEWD LVIRRESAVS
IQNQSVRSVY VDAWTNTTTD TAPLTKRQPA IQALGPVQIE PLTFYREPAT RRPWRRKMAI
EQDEQERDHR AWFHRYAIFL GQWGMAREEE NRTSPYKIAL LGTGVDCALI LSHDCHQVIR
GRNFTSTGEN GSWDQEHAGH GASCLTMLLE TAPFAEFFIA KITDRQRISN ADTIAQSIEY
SVKEWKVDMI VLPLGLHIHH DGVANAISQA IRQNIICLAA TGNDGANTRA AFPARMHGVI
PIFSTDSYGN PSPYNASPMR GRKNFSTFGE NVMVWRDDRT DGPSYKSGTS FAVCIAAGML
AAMLVFARDY LQLDERDWNT LHTPAGAEKY LELMSSSRGG YEYVAPWLLI SNEILMENSS
GSEVDFKNAI KSQIVTALRH LR
//
