ID E9FB74_METRA Unreviewed; 807 AA.
AC E9FB74;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Peptidase S8/S53, subtilisin/kexin/sedolisin {ECO:0000313|EMBL:EFY95074.2};
GN ORFNames=MAA_09523 {ECO:0000313|EMBL:EFY95074.2};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY95074.2, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFY95074.2, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFY95074.2, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY95074.2}.
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DR EMBL; ADNJ02000004; EFY95074.2; -; Genomic_DNA.
DR RefSeq; XP_007825712.2; XM_007827521.2.
DR AlphaFoldDB; E9FB74; -.
DR GeneID; 19263809; -.
DR KEGG; maj:MAA_09523; -.
DR HOGENOM; CLU_003559_3_2_1; -.
DR OrthoDB; 5606at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07489; Peptidases_S8_5; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR010435; Fn3_5.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034187; Peptidases_S8_5.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF06280; fn3_5; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 192..446
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 490..600
FT /note="Fn3-like"
FT /evidence="ECO:0000259|Pfam:PF06280"
FT ACT_SITE 201
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 242
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 413
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 807 AA; 86152 MW; 496B1EF5DBF6842E CRC64;
MNELANIGLA FSSLSSHLQS WAKFAMLRSS LVAVLCLAAA PFVHVHAQNG TSVKKGFRHF
LILECEDGQA LEPVIQAVEK NGNQVRRKFE SKIFRGLSVK LVGRDMEQIE GVKKIWRVQD
SFIDTWSFAR RGQDLQEETW GPLPTKPPLT AARQPTCNKT TVESMCGSNI PEFQWPHIMT
QVDLLHKQGF IGSNITIGLV DSGVDYKHPA LGGCFGKGCK VAFGDNLAQD KDGGDPMDCT
GHGTAVAGVL AGYDEAGGFV GVAPNATLGA YRVLDCNNKG QEDDFMAGLI RAFDDGVQII
VSSAVIQTIN WASSPSAIIA SRIVSNGVPC IIGVGNLQDL GLFSTSIPST GRGVIAVTSF
GQADDSTTGA ILGSNSASGP TWDLDIKPNV GAPGRRVRLV NLGRGYTVDS GTSFAAPFIG
GIVALIAEAR RTFDPILIAS LLTTYAAPQI NPYENEGSEY YSVARQGGGL VQAWEACRAT
TLVHPSALIF NDTDHRPSSI DLAITNKAES EVTYELSNLP ALSVYTLTKD AIWAGESQES
ISAGAAVTLS ENSLRLRPGQ SATIQVSASE PQNLDTSRLP VWSGWIAING SDGSRLTIPY
QGLGGSLQSA TIFDANKKRL DMQVDSSQTA YDMSERQAFL LTPPPANSSQ QFAKVSAQLL
GKYANDLWTG RPVAVFYLVF GSPQVQIHVV PLEICTRQDP PPHPGNTTVS SASAPADRLC
VPESMVTDIG GVKSLGQVLG YPKDFVRRGR LEAVWDGSLA RGEYAPPGSY KLVARALAIF
GDANNQSHWQ TVESVQFAIT YNPATAA
//
