ID E9FR19_DAPPU Unreviewed; 865 AA.
AC E9FR19;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN ORFNames=DAPPUDRAFT_94321 {ECO:0000313|EMBL:EFX90080.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX90080.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX90080.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732523; EFX90080.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FR19; -.
DR STRING; 6669.E9FR19; -.
DR EnsemblMetazoa; EFX90080; EFX90080; DAPPUDRAFT_94321.
DR KEGG; dpx:DAPPUDRAFT_94321; -.
DR eggNOG; KOG0510; Eukaryota.
DR HOGENOM; CLU_009006_0_0_1; -.
DR InParanoid; E9FR19; -.
DR OMA; CCETEGS; -.
DR PhylomeDB; E9FR19; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR47143; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR PANTHER; PTHR47143:SF3; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 426..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 230..262
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 263..297
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 298..330
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 479..680
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..99
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 97930 MW; 6C9469DECB7FD5DE CRC64;
MSNRKSTKKD TSGLEESGAF SNDAFVKDEG PPVGNSEREI EKYRRSTIKK TISANRFFNK
PIEDENEDDG VHPEDQSRHL SMDKKKRKAY HRQHCAKRKF RDSQNHNGAP TKKKQSSKKR
MPRDEYGHRL ERAFSISSES NTSHTELQGI DHHENFSSMP WYSSCSIWLQ QMLAAAVEDL
INTKEAFVIR MCKSFLDDSA DQPDWDTLPS DCHSIGVLTS KAQINTKDAL GRTPLHLAAL
SQSVDSVKEL LENGAEIDNC DEMKETPLHG AVVKCRQSTD VVKLLISKGA NVNAKDQFGQ
TPLHIAAFNE NSKLAILLIH SGADLSIKNR AKISALASVV RRVPDALTAI SRKLDSAVDV
VDNEPADPDC QLKLDLRVLV PGGNQQNVGE MGFLTSLVAA EQRHILQHPV IGAFLHLKWM
KIRTTFVVSL IFQLLYVLAL TSNIYSIYVV KMNKRVNNTQ KSEPSNATMT QFADWPMELD
TTLWYLTVLL GAATGVKEFF QLYCNVHEYA RDIENYFQLI SILGMILILS PHPMHTDEPD
KGDWQHHVAA IVIIVAWINL MLHVGRFPVF GLYVQMFTTV AWNIGKLLVA YMSLILGFSL
GFAVLFPLEN RYNDMPYALL TTIVMMTGEM EYAAMYTEGK IKYPGTTHFV FLVFLLFVVI
VLMNLLVGLA VSDIQGLQKS AGLDRLVRLT KQIARMESFV FFPWPIHFSS LWSKVPRREF
IRRNVLVVSP KTRKNYNFRP NDPRDRSFPP EIKESLLKII AVRIANKKKG AQQKTSHVPI
IRTATIPLDS NNGELFTEVM NRVDELFHNY MTQIVTINST IEDQLAQLTA KYNYPSTRSR
QTRHSCDCSM INEESFRVPG ISSQA
//
