ID E9FSS4_DAPPU Unreviewed; 381 AA.
AC E9FSS4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Follistatin-related protein 1 {ECO:0000256|ARBA:ARBA00019697};
DE AltName: Full=Follistatin-like protein 1 {ECO:0000256|ARBA:ARBA00042478};
GN ORFNames=DAPPUDRAFT_303124 {ECO:0000313|EMBL:EFX89772.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX89772.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX89772.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; GL732524; EFX89772.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FSS4; -.
DR STRING; 6669.E9FSS4; -.
DR EnsemblMetazoa; EFX89772; EFX89772; DAPPUDRAFT_303124.
DR KEGG; dpx:DAPPUDRAFT_303124; -.
DR eggNOG; ENOG502QQAG; Eukaryota.
DR HOGENOM; CLU_726195_0_0_1; -.
DR InParanoid; E9FSS4; -.
DR OMA; CIERCKP; -.
DR PhylomeDB; E9FSS4; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0030510; P:regulation of BMP signaling pathway; IBA:GO_Central.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR PANTHER; PTHR10913:SF13; FOLLISTATIN-RELATED PROTEIN 1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..381
FT /note="Follistatin-related protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003236345"
FT DOMAIN 52..106
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 207..242
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 290..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..309
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..365
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 43412 MW; 96D4DA077F97F1F1 CRC64;
MLRILGLVSL FCILFQAALA SNSEENALDM SLVEDECSMM VCRAGRECKV GADGEAACAC
LATCPDHFVP VCGSNNQSYD NFCLMHRDAC LTGVHISLKK KGYCSNKSIK KKSSKKDKLK
DENHFEPVVC FQWERDALRR QIINYFRHHT ADQSWYRPDL KSYEKQFARF FMCDTTKDNF
VDANELAACV TEVPFALRTT AATNELVKVL CVDAIIDSAD TNSDWRLDFE EYKTLMDSSF
QPKEKLCSLE GKKYEDGSQT KVDCNDCVCA CGSWVCSSKK CDEELNEIDD LDEDEDLDDE
LDEAEDQSED NTKDEVKILK IEEDIDLKID DPDEDQPPKI NSDDDDDMDD EEDEEDDEEE
DEEIDVEPIK KSSKNKKKKL T
//