ID E9FUR2_DAPPU Unreviewed; 317 AA.
AC E9FUR2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Spaetzle domain-containing protein {ECO:0000259|Pfam:PF16077};
GN ORFNames=DAPPUDRAFT_311125 {ECO:0000313|EMBL:EFX88879.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX88879.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX88879.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732525; EFX88879.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FUR2; -.
DR STRING; 6669.E9FUR2; -.
DR EnsemblMetazoa; EFX88879; EFX88879; DAPPUDRAFT_311125.
DR KEGG; dpx:DAPPUDRAFT_311125; -.
DR eggNOG; ENOG502S688; Eukaryota.
DR HOGENOM; CLU_877888_0_0_1; -.
DR InParanoid; E9FUR2; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005121; F:Toll binding; IBA:GO_Central.
DR GO; GO:0021556; P:central nervous system formation; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR032104; Spaetzle.
DR PANTHER; PTHR23199:SF18; PROTEIN SPAETZLE 5; 1.
DR PANTHER; PTHR23199; UNCHARACTERIZED; 1.
DR Pfam; PF16077; Spaetzle; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 190..281
FT /note="Spaetzle"
FT /evidence="ECO:0000259|Pfam:PF16077"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 34105 MW; B1971114B1FCA153 CRC64;
MDDAMIFGEG GSSSSSSTDK VLVNGANSGG ASIDFGVEDR MKNRSPQLHH GRPACNKSSS
ATTTGDSLDA SASPQSEAAD VSPSSVDFFI DQPDWSPLVN ESQCQSYGPS QFCENVTNYP
AEAISKILMS ENGSILKTFL ADNTAQPIPS ASESDESMVL AQRKPGGAPA VTAHAINTRT
KPLESGNVQH LCESMTEFKF PKSAKNNQNE MLTIVNQDNI SQPITVETCR NENQPCKYAD
NFPAGYKSFC MQKYVTHHLA ALKNGKIVRE AFTFPSCCVC VLKLWDARTN SAAEARGIAM
PSSLRRMASE VDVQQSP
//
