ID E9FVE7_DAPPU Unreviewed; 1210 AA.
AC E9FVE7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_310752 {ECO:0000313|EMBL:EFX89117.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX89117.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX89117.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL732525; EFX89117.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FVE7; -.
DR STRING; 6669.E9FVE7; -.
DR EnsemblMetazoa; EFX89117; EFX89117; DAPPUDRAFT_310752.
DR KEGG; dpx:DAPPUDRAFT_310752; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_269829_0_0_1; -.
DR InParanoid; E9FVE7; -.
DR OMA; CAEDRPK; -.
DR PhylomeDB; E9FVE7; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR PANTHER; PTHR45930:SF4; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 757..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 921..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1164..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1187..1204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..363
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 753..937
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 311..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 131549 MW; 9EE014AE3DE7010B CRC64;
MRENSSVDGK KKLVNSGVPL ILTLVVLLCV LESSIVKGKT EFPKTNADLQ ATSLCPSACT
CSEQKLKLSQ GSVEQELNPS NHKETTENLN VYSKIKPEIL KSGIKVQCQN PAFIVSVKKL
NLQSLLVENV VQYDLSGNSL TRLSGEDFAN GNYLMLQKLI LKNNQIEEIA ADTFSTLKNL
KYLDLSNNFL TNFSSAIIEN VMSLDRVKLN GNPLKCNCHL SGLLTYASSR NIRLQGTCLE
PPRLKDRSLT RLVVEELACP PEDPVGVEIR PNTNQLVFEG DPLKLSCKFK AGRAIAPNWL
HRNANNQTAT VSPGGAVELT TSSRGTDQGT ETESQLLIRH LLPRHGGMWA CSWGGRTASV
EVTVLSLTTP TCSSHVTASN KGRYSWPRTM ANLKIALPCQ ANPNLQAFRL CGALGHWEEP
DLNSCFYLSE VTKVLEQFAK TNLTFSKTSA LESARRLKSY LTDVISLTDP HEAIFVTQTL
HNYLEASGKH PELLPIIMDI YSILITQDPQ LLADSRHGLV GLLQQAPLKT QEFEYRSSSL
VIEKCGIIGK SLSAGTCTWR RTSETGSSKS DSKTKARSPY QASCGQNSNG TGTIEASVRV
PLISEGAFSE QSVVLSLVLS TNAFVSAKSK PLATSVLGVT SGPVSNLINR TTPFVMTIRL
SRAIGTSDRL VGARWNHYTD QWSPEQCQTL KSSGLMSEGD SVTFQCCCGF GFFAAFTTQD
EEDEQNLVEQ VTTKSGSGSI PGSAYFPGQL HLLPSPVYVG SVIGLLCHLT ACLCYLIHRR
RLKMTQPTRH ALINTWISVA LLMVAFTLGV RPVLGKLPCQ IAGLLLHYLT LSSLLWMVVN
ASSLYKHITK SSRTDPETDS SLMEEAMAVG HDSPPKPALR FYLIGWGIPL IVVGIAGAIH
LEQYYGPKIC FLAWTPSLGA VGLPSAILIL LILTFHLLTW CFLRHTSRLA AIHQKQLTTL
AAVEEPGAMA AAAAASSDGN KDVGMCGRMQ KDKKTCGLQG GYVPLAVDGD VTSCPSNVTN
QVTETSDLAS LSSDHERIAL LIQRGEAEGA MSANESVVLH SGRSESERPL LIVTSSAASS
NDDRLEDGAK TDVDDQGHSN PLMASFTDDG DSKKRECASS ISPSVMEPGI QNAIFHLPVQ
AVIPPTPTED ADEKSTLSQL RGQFVFLILF CLTWLSGLCV VQQDCMLYFF TFLLGRMSVL
PVLIRTLRSI
//
