ID E9FVY2_DAPPU Unreviewed; 2565 AA.
AC E9FVY2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=FERM domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=DAPPUDRAFT_41019 {ECO:0000313|EMBL:EFX88629.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX88629.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX88629.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732525; EFX88629.1; -; Genomic_DNA.
DR STRING; 6669.E9FVY2; -.
DR EnsemblMetazoa; EFX88629; EFX88629; DAPPUDRAFT_41019.
DR KEGG; dpx:DAPPUDRAFT_41019; -.
DR eggNOG; KOG4261; Eukaryota.
DR HOGENOM; CLU_000364_1_1_1; -.
DR InParanoid; E9FVY2; -.
DR OMA; VDMTQHY; -.
DR PhylomeDB; E9FVY2; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001726; C:ruffle; IEA:InterPro.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd10569; FERM_C_Talin; 1.
DR CDD; cd17089; FERM_F0_TLN; 1.
DR CDD; cd17090; FERM_F1_TLN; 1.
DR CDD; cd12150; talin-RS; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 7.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037438; Talin1/2-RS.
DR InterPro; IPR015224; Talin_cent.
DR InterPro; IPR036476; Talin_cent_sf.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR015009; Vinculin-bd_dom.
DR PANTHER; PTHR19981:SF1; RHEA, ISOFORM B; 1.
DR PANTHER; PTHR19981; TALIN; 1.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR Pfam; PF09141; Talin_middle; 1.
DR Pfam; PF21692; Talin_R4; 2.
DR Pfam; PF08913; VBS; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SMART; SM01244; IRS; 1.
DR SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 6.
DR SUPFAM; SSF109885; I/LWEQ domain; 5.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 88..411
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2328..2565
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT COILED 2492..2562
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 2565
FT /evidence="ECO:0000313|EMBL:EFX88629.1"
SQ SEQUENCE 2565 AA; 274101 MW; E73C5B4BB432DF01 CRC64;
MASISLKISI VEKDVVKTMQ FDPNTAVYDA CRVIRDKITE ANLGQPKDYG LFLADEDPKK
GIWLEPGRNL GYYVLRTGDL LEYRRKMRTL KVRMLDGTVK TMLVDDSQPV TNLMVVICTK
IGITNHDEYS LVRENLEEEA ENKPNFGTLT LRRKKEEKEP RDQKMEQLKK KIKTDDELNW
VDHSKTLREQ GIDESETVLL RRKYFFSDGN VDSRDPVQLN LLFVQARDSI LNGTHPVTLD
KACEFAGIQC QAQFGDYIES KHKPGFLDLK EFLPQSYMKV KGVEKKVFGE HRKHNGLSEI
ESKVAYVKTA RSLSTYGVTF FLVKEKMKGK NKLAPRLLGV TKDSVLRLDE RTKEILKVWP
LTTVRRWAAS PNTFTLDFGD YSDQYYSVQT TEGEQISQLI AGYIDIILKK KQAKDHFGIE
GDEGSNIVED SVSPFKATIV QHTAGSGIKS GKVQTESVAK PAIVRAADVP QKYDVGQTQP
PQLPTLQGLA TVAHAPPTVQ QPKVTSVLTE PQRALISTIS EGQKAVEEAE RILDTKLQVP
DLGTDPASLK WKQNQLDTNK QNVSSQIAAM NAATASVITL TSGPPEDVDH QAVGAAISTI
SSNLPEMAKG VKLISALMEG EEHDDRLMDA TRRLCKAFSD LLDAAKPENN NMRQNLLSAA
SKVGETTYDL LKQLGEADNS SRELQDMLLG LAKAVANTTA ALVLNAKAVA AACPNETERQ
QVIAAATQCA LATSQLVACA KVVAPTISDP ACQQHLIDAA REVARAVEGI LALCQQTCRD
DKLEANLRKA AGDVASALND LLAHIKEGTG RNRATESVHE GAVDNILAAS DRLFAAQGDA
AEMVRQARVL AQATAQLIQA IKGEAEALPD SELQQRLLAA ARSLAEATAR MVEAAKACAS
SPNDPNQQHK LRQAAEELRG TAESAAGEAI KKKVIKRLET AAKHAAATAT QSIAAAQAAG
PHNSNPTSQD QLLAACKAVA DQIAKLVQGV KGTLANPESP ASQLALISAS EEFIQSGNPM
VAAAKTALPT VNDPSSSMQL NNSSKQFSTA LTDLRTAVTK ARDTCGPLEL DSALDMLYGL
KDELDAFSGA VDASKLKPLP GETAENTAQQ FSATSKAVGS NMAQLLTAVN QGDEKHTGMA
ARSTAVALQD LTDAVRGVAA TSDQPEQQHK IIDSAKDVVV QAITLIEEAR SAATNPQDIA
IQQRVTQIAR DVSQSLSKCA GCLPGQKDVD EAINSINSAS EILEGERYPR SDKSYHELQT
MLGSAAADLN DAAGEVVGTA RESPTRLAWA SKTYSTSFCY MMNVGMEMAG QTKDTETRSQ
MIVSLKNITL VSGKLLTVAK TANADPSAPN AKNNLTAAAR AVTEAINGLV DVCTASAPGQ
KECDNAVRAI QSTRSLLEKP NEPVNDMSYF ECLDTVMEKS KSLGDGMTGI ANNAKKSEHE
PFGEAVKDVS NAITGLVEAA AQAAYLVGVS DPSSVAGRSG LVDQAAFARA SQAIQSACHA
LSSPSSTQQQ VLSAATVIAK HTSSLCNACR VASSKTTNPV AKRHFVQSAK DVANSTAKLV
KEIKALDQDY SQRNRDNCAA ATQPLIEAVE NLCTFANSPD FASIPAKISP TARQAQEPIT
SAGKSIIDGS CSMISAAKSL ALNPKDPPTW QALANHSKSV SDSIKKLVSS IRDKAPGQKE
CDDVISIMSN CVRQLDQASL SAISQNLSPR REKSAQAFAE QTTNCAMEIA DRIDSVRSAA
KGEAEKLGHA VTQISHYFEP MVVAATGSAS YLLNSKQQMM MLDQSKTVTE CAIQLVLVAK
EAGGNPKAVQ VHTDLDESAE AMKEALRDLL STVETVATEA GVVSGLVDSI TASMNQMESR
AQTVIQLSAD GSSFVDYQTR MVQATKEIAR LSQDMVAKSG SDNVSQLGQL GASITHLYTQ
LATDTQGAVA KTSSVEIAMR IKSTVHDLGR TCIDLVKAGG ARQGAPDDVF TQRDLSDAAR
LVGEKASQVL AALQASSRGT QACINAASTV SGIIGDLDTT ILFATAGTLH AENEDESFAD
HRENILKTAK ALVEDTKTLV AGAASSQEQL AVAAQNAVAT IVQLSDVVKL GAASLGSNNP
EAQVMLINSV KDVASALGDL IHATKSASGK SINDPAMIYL KDSAKVMVTN VTSLLKTVKA
VEDEHTRGTR ALESTIEAIA QEIRVRTFVA FDSPELPRVK YTPEDLVRVT KPITLATAKA
VAAGNSCFQD DVIVAANVGR KAISDMLTTC KGAAYSAETN DIRSKTLLAG RETALQYREL
LQLVLHVLSR PNPAANLEIK NNFPVVSRKI AHCVTGLVSM AEILKAGTDW EDPEDPTVIA
ENELLGAASS IDAAAKKLAN LRPRISSTKE TDESLSFDEM ILEAAKSIAA ATSALVKAAS
AAQRELIDIG KISRRPQVDS DDGQWSEGLV SAARLVAAAT HSLVESANAL VQGQSSEDKL
ISAAKQVASS TAQLLVACKV KADPDSKSTQ RLQAAGNAVK RATDNLVKAA QQAIAQEEER
SLVVNRRMVG GIAQEIDARS EVLRIERELE EARSRLTAIR RAKYR
//
