ID E9FW08_DAPPU Unreviewed; 730 AA.
AC E9FW08;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN ORFNames=DAPPUDRAFT_233883 {ECO:0000313|EMBL:EFX89007.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX89007.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX89007.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; GL732525; EFX89007.1; -; Genomic_DNA.
DR STRING; 6669.E9FW08; -.
DR EnsemblMetazoa; EFX89007; EFX89007; DAPPUDRAFT_233883.
DR KEGG; dpx:DAPPUDRAFT_233883; -.
DR eggNOG; KOG2513; Eukaryota.
DR HOGENOM; CLU_006685_2_3_1; -.
DR InParanoid; E9FW08; -.
DR OMA; RELCWAP; -.
DR PhylomeDB; E9FW08; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF74; ANOCTAMIN; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..730
FT /note="Anoctamin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003240376"
FT TRANSMEM 220..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 367..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 421..440
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 538..557
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 648..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 210..670
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 730 AA; 83993 MW; 3528B3B00F6B3D41 CRC64;
MSSLLNQILA ITVIFLKMAK SNIEDWPAYV LELSTKEAKS EDVSLLLNWI LGAFSEYGLQ
MSSSTPTPGQ CRIRSIDGKL PIGSLLDSGT LEETPLLDND EITTLQENLD HDGGEQTAMD
ARSIFTPADI LWMIRHEIES VRSETKQVLQ IGDMKMTLFQ GQSIVEKFLH KKLINNIYPL
HEPEGLKRLG HDWLINSFKC ATKQLPLNEV RRYFGEGVGF YFAFLEMLTW ALLAPTCIGI
VHHHFLQSEF EIQILFCVLY MLWAFILMEF WKRRSNGLCF LWNTKSKYGG GQGEPRANYR
GPLMIDPITG QLQPYYPRWK TLIKLYCVSL PIVLICTLVA FWVMLESIWK ETMMMEWTST
WPKDDLFWHL LALCIVSIPT VIYAILVWFA NQIYRKLATK LTEWEXHRTE SQFESNRVTK
LLLFEFVNNF MSLFYIAFYL QDIPMLQWQV ALMLLVFQVI NQLTETLFPY LNLCYVLKKN
PINLKPTEKD EGVNKTLERL NVRILAPDNP IVKQAYKESL LEPYEGTIED YLELYIQFGY
VLLFVAAYPT ASLWAFINNV AELRVDAFKL VHIHRRPTPA RVAHIGAWEP AFRMICSMAV
VTNCGLLYVM SSSPSTPAVD GEELSGNPVV GPVTNWSRAM ICVSLDHILL AVQSILFVLI
PAVPRWVHIT AATRKAAQEK ELRKLKKIHH RSFAEWMHPV SLATSEVPRV KRNILLRAMQ
SQDEDSEISH
//
