ID E9GG69_DAPPU Unreviewed; 4191 AA.
AC E9GG69;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=UBC core domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_317519 {ECO:0000313|EMBL:EFX81544.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX81544.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX81544.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732543; EFX81544.1; -; Genomic_DNA.
DR STRING; 6669.E9GG69; -.
DR EnsemblMetazoa; EFX81544; EFX81544; DAPPUDRAFT_317519.
DR KEGG; dpx:DAPPUDRAFT_317519; -.
DR eggNOG; KOG0895; Eukaryota.
DR eggNOG; KOG1101; Eukaryota.
DR HOGENOM; CLU_000111_1_0_1; -.
DR InParanoid; E9GG69; -.
DR OMA; LDAQCKL; -.
DR PhylomeDB; E9GG69; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:InterPro.
DR CDD; cd00022; BIR; 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR022103; BIRC6.
DR PANTHER; PTHR46116; (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME; 1.
DR PANTHER; PTHR46116:SF47; UBC CORE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00653; BIR; 1.
DR Pfam; PF12356; BIRC6; 1.
DR SMART; SM00238; BIR; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT REGION 519..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2007..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2171..2200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2175..2200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4191 AA; 454734 MW; F108CB931F7B8865 CRC64;
MSEDTKLFTI AEEGCLRVSS YIRRIVYHRS LNVLLVFSSN GPRETEIKVV VLDIASGTVL
HDTKLSLAQS NSSGSGLHGE NVVFDDELLD TEVDGIGLPT FKDPLKCLSI AERGTLIVAH
HGFLGVRKDF GRALLLESIL RPPVMSEEDI VHVELPHNEA MLLRECLQTM DLGQTDPELG
NMQTQVITLL TKHMKQYLFS VSKGSRMSSN WCIVNLELPL KTLKAVCTHA VLELKKNNRS
IPALPIASSI VVRLATLQQQ PIQQPLPQPS SASSSAVVKE DIAPFYHSAS STSNNNNSSN
SFTGNNAWEL SSCPALHPMT SEASRRETFA SWPHMNYKWA LPSQMAEAGF YHQPNTPESD
RAVCFLCNVC LICWEPSDEP WSEHERHAAT CPLVKGDYTS NVPVDVSMAT QPAVQQDSIP
SETIACISTT TCPDLFATST AGGLVVLWNI SGTLKREVSI NAGHTSQLCP VRVTALSVVS
GSFSNGHQPI RCSLVVGAKL GDQLEPFLVV YDVTWTRAYQ DDQPEPGPST PTAGSSGSTI
KKGGTTKKVL PVTHVLNPNS GGLVSAGSNA ESSANPGLFF SFGDDDEEMY TISSTMDANE
KLGKATGLLN KLMHNMGSPF TNTVMPQLMM GEKITTTHAY TSSTSVVAPP PPPFALSPKV
SDQPEVTLNQ RTLINLKECG IDGELDVVFL IPTWDAGHLI AILSPPDKSE LSRNTENVAI
EKVSSHILLF KLNVGEAGLV ERPVCQLKVG AADEPRCVVM LPSGDRNDDS EWSAEEDAAM
HGPMRAVVVT KDGRLRLLLM DPNGSTPQLT WLDMESVSPH KFLDATYCSS VERVCATTDK
GDLVFFKIIT HAGAAGFSRL HPSGKSGMRK GKEPSPTKLL IHQPLTSETL QSLYELTLAE
KLPQACQLTI TAASCWMELA VTQRQRRQPQ PWLLQPGSST TPNNTGEDGL QMARLFKLQQ
DKFSWDEHFF EMSLPPGISV SHVHLRFVLA PSCSVAPEIQ VSLLEQRSRS LQWGRSSLNA
NPTEEVDNLI NFNMGQPSPR FTSSASNTES ASNPILAQDY LDAHDAVLLC GPFKLNQFLD
ASGQVATLTL NSHQLLQSTA RNFLIHLKYI PSVAHPNSLS LLNIPRPMTN PCGRRTIQTK
GCDWIQEVAI SVQRSKPTSI PHERAHRCAL LASSNFTGQL LEFGFRSILR REHIMVLGIL
NWKTAAHYGA PPGVACLTTG DVAGHVIEIF NQLKSLLDRF VIHGNRTTAQ QVVQLLSSSH
ELGICLSEEE VAVITKQMMH CLLQQLGSLQ NCASPSVVHW FLVLLSRVYL RSQTEVAGPV
WAVLTRIIAE LHRRREPLQQ LLQSRYGFYG RPFETELMFS LTEDHQQQQS SASSSKPVRS
NIAASFAALN QLVNPSSTCD KDKSYNYLDV LSLKRSCDLV DVEPLPFTLV SASDGVRLEK
ADTGSAQFTA VALNGLVEAS KLVSHKDTHA TSHRWQHLLA INPPLVIVME RLHSGGRKFV
VLDFGAPILL TDVYIPACPD WVSITVDVWN RLERNQNDTD LVRLAVSSDI NRRPIVLHDL
QPPLVCRFLR LTITGRQGLS ASSCKTSIGS FYGHSLILPN DLVVPAMQAE GIPILDREEI
MENIATLEVL ADHSQCHYNL AGDRLRSLLR PLLTNWHKDA SGSSTHHIDH YLQSQVNAGQ
TGNGDANEDA KIVEAYEECL KLQRQQNLLW SALRRLRRCL VEMDKKQDGS ASEEESVAIS
QASSHKLHYI AQSLVNVLLA SSALKKQIKI ERKTAEQLFQ HLYVTSGPAS QLSTAALLSQ
SDDTYRWMPN FLADMLRKTL SSDPSTSLIP KDRVFVTLLF MGFKAIQLSS GIHLLDPILA
VLNEQLSVLE NRNNSSPFAL SHLDLPFVNW LLLFCCCCLD RTASVTTKET KTRDQRWDFM
QGESLLSRDG ATAGEPKNAG GSAASRIYRR KLQKKLMQQP HYGVSWPSGG VLSGSNKAKF
ILAHSKQKGG GFAMDSGVQM RRTAMMDDEM DSNGPDDKDG GNGSRTMPSS CGQPICSSSG
AARVAKNLIS FLLVIGASGA HEETFLLTCK VLARLIGASQ NGLRLGHIAD EEQLTTLLRM
AASANGQPTQ LWLNHAIYCL LIDYLRATSS NKSNMIASGD SGGASKSCSV NSMFTHGATG
SRYDDILRSV GSEPEAGSSG INGAGSSPST HMNSTGSSSS NTLSFFKSKM KMGQVSKKLP
PMAVPPELLA YEQAKLAAES LKVDQHVDDL LELFENPNSE SVPPVLKKAW PSISSVMKNL
AECKSSLSAS GYGATTGILS AEEATSSGVW DLRDESRSDG PWKHKTDILS DAFFEAVLQG
LTSSFHDNKR RPLPEEIPGD PITAPAQPDQ KLLSSAFNNL FSSASYLRIK TDVIASLKLW
VLLNSENYGS SLDSDGGASS SVTKNNGDSS AILLNPEAIR GVLEVLAKIP VLDVGDWTAV
LRSLTWLSSP RWLLTEPDQQ QHQMESESSH SEELADQMCA GTVIRSPYLT AILYNFISGQ
GLVPYSLGDK QLVGPSIVST LGDVLSCLKV WCNTALVGSV LGCQLRNSLF ELFLELAVPP
HGPIFRGIGP LDAQICFLES LLKLGVQGLD ESLSIRVIQA VVSLSQMFLS RSGGLSCIDS
SSQLSEDDRI CFSGLHATSA LSGPLGGGSS GNNTGRPSAI TPSVLLTLSL QLAIRLVTNA
EYGPSLNVAD SLLSTRSVMD ELLDAANYCQ ASSFASSLGA TALGDFDVAF SHLHTVADFT
LELLHQISIK TSNVRLLFYR IIEYIKPGVA TSVFSSQGCS DLSEPLLIFV LYVLRTKENV
SIFHEVDGFK EVCLALSRTP IQLFNSHSRL VSNVLSYVSQ TTVANGQGAN RPRLNSRQAR
SGAGSIFPGA TSSSAANAGM LQNSFVDAAS LPLAVFRRSC LRLDDDDDYG LLNLAPLSTI
SCSHPSAQPA DVLLQPNPPH RRARSPSWSH HFYPAEQFIE LTITLPCPVL VKEIQLHPHL
TSLATCPSAV GVEMSPEGSS QLYPVGAVLS ATGLTTIAFK LESPQVAALV LLRLYKPRDS
SNIGLAQIRI LGSLALPSSE QSASGPMAGQ HQPGLTWLCV LHHCLSVAEK SDNSDLMGSL
RQTAGSLERP GMVERCCGLL NAHFTSPRAG ILADVVQMAS DILLHLGRHS SALAHQFIRL
QLQESPRLLL GCTPPVANVL YELCSAENES IATFATPPGG SGQALLFQWL HRAADQGSLS
QAVSTSMVHC ASAVLWHSPC AMEKIVNYDF AKALFEWTKK IHSMELKIAV DFALCSVCRH
YPNIFTSLLS SITTAESSSS SSSSSITSTT LNSILQSKSL METLGRAAQS ELALEKLFQS
GLLDLVSQTM SEYCQCVLKR HEMVAADLTE RVAVAFEFWT LLCEEWGSGV SRDVLAAYLF
DKSLLEMLLQ ALCSNSSGDC QSNRLQTSRI EDAAVAFFRQ FCWAHRENSR RFAEILLSVL
QPVGSSSKLL TGFTRRLLLQ LLLEQEKIFV YVTSASGQVG LPVSASSLSS MTIAEPRHPA
FNHGKKHKLL YISAETTCSD FIRLLTDSMS VPVLNDMKSS LNLTNKRLST VDRLLASSDL
DKKAKLSALD SEDQQRRALS QILQNQHYLA LFDHPNVPLS GNWTLSQALS HQRLENPTSR
GALCLRLNTD LDSVNSSPTP ATPMDQPTQP LTTLLEEFAA LGGLAVLSKH LPMLLCASTS
TTSSVAFESV TLSVKGGSGS VAQVSQPSMT NPGTSHLSNH VNGVTSETID SWVKLDGGSD
DMDEEMDEIL MPSGYFPPPT PQYMNAKRSK SAGQSLPTTC ALPLHSLAAF SLFLSMPLYT
EAVLQDRRRA QMLLRLALGV SDDGQGGNIL NSSDAALFPV LPFVLLQQVL DKHPLDSEKG
AVIRQQAVDM GVLQLLLACL AVFTQQVTSA NVAIPSLNVQ FVVGTPNGCS APAKNESIGN
ASDANQAAAT QTGSILGAVT SQSQLQQQQQ QYWAKGTGFG TGSTAQTWDL DGAMQRQRQQ
EEQATCLLHT LSAYVHPSCP PIALIQPGFT GSPVLPTELL NIVLASHLVA AICSYLRNDS
VMDMARHVPL YKAVLLLLRS IAACPKLVPL LLPSSSGNNK GSSSTSGSSQ SIHALLRKLK
NYVSSYTARL ASVQNRTAST QEDSDSEEGI ADLSKDICET WAIVKVLLMN E
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