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Database: UniProt
Entry: E9GGF2_DAPPU
LinkDB: E9GGF2_DAPPU
Original site: E9GGF2_DAPPU 
ID   E9GGF2_DAPPU            Unreviewed;      2057 AA.
AC   E9GGF2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   28-FEB-2018, entry version 48.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=DAPPUDRAFT_50150 {ECO:0000313|EMBL:EFX81393.1};
OS   Daphnia pulex (Water flea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=6669 {ECO:0000313|Proteomes:UP000000305};
RN   [1] {ECO:0000313|EMBL:EFX81393.1, ECO:0000313|Proteomes:UP000000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21292972; DOI=10.1126/science.1197761;
RA   Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA   Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K.,
RA   Bauer D.J., Caceres C.E., Carmel L., Casola C., Choi J.H.,
RA   Detter J.C., Dong Q., Dusheyko S., Eads B.D., Frohlich T.,
RA   Geiler-Samerotte K.A., Gerlach D., Hatcher P., Jogdeo S.,
RA   Krijgsveld J., Kriventseva E.V., Kultz D., Laforsch C., Lindquist E.,
RA   Lopez J., Manak J.R., Muller J., Pangilinan J., Patwardhan R.P.,
RA   Pitluck S., Pritham E.J., Rechtsteiner A., Rho M., Rogozin I.B.,
RA   Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA   Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D.,
RA   Tu H., Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y.,
RA   Shaw J.R., Andrews J., Crease T.J., Tang H., Lucas S.M.,
RA   Robertson H.M., Bork P., Koonin E.V., Zdobnov E.M., Grigoriev I.V.,
RA   Lynch M., Boore J.L.;
RT   "The ecoresponsive genome of Daphnia pulex.";
RL   Science 331:555-561(2011).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; GL732543; EFX81393.1; -; Genomic_DNA.
DR   STRING; 6669.DappuP50150; -.
DR   EnsemblMetazoa; EFX81393; EFX81393; DAPPUDRAFT_50150.
DR   KEGG; dpx:DAPPUDRAFT_50150; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; E9GGF2; -.
DR   KO; K04834; -.
DR   OMA; YMIDEDH; -.
DR   PhylomeDB; E9GGF2; -.
DR   Proteomes; UP000000305; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000305};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     84    110       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    155    177       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    189    207       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    213    235       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    345    370       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    759    783       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    804    827       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    833    857       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    877    910       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    930    947       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    968    989       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1268   1286       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1307   1329       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1335   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1399   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1503   1529       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1622   1641       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1653   1672       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1706   1734       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1806   1829       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       91    377       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      457    689       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      768    993       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1003   1262       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1266   1539       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1589   1839       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1844   1899       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      363    396       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2057 AA;  232664 MW;  5C4E5F78EA6707F1 CRC64;
     MRYDEDDEDE GPKADPTLEQ GMPLPIRLNA VYSPELTAVP IEDIDPYYKN QRTFVVISKG
     KDIFRFSATD AMWLLSPFNP IRRVAIYVLV HPLFSFFIIL TILTNCILMI MPPNAFIEST
     EVIFTSIYTF ESAVKVMARG FILKPFTYLR DAWNWLDFIV IALAYVTMGI DLGNLAALRT
     FRVLRALKTV AIIPGLKTIV GAVIESVKNL RDVIILTLFS LSVFALLGLQ IYMGVLTQKC
     IRSFPSDGSF GNLTDDNYEA FVSNSSNWYK DDTDNYPLCG NSSGAGPCPE NYTCLQGYGD
     NPNYGYTSFD SFGWALLSSF RLMMQDYWEN LYQLVLRTAG PWHMLFFIVI IFLGSFYLLN
     LILAIVAMSY DELQKKAEEE EEAALLEEEA IRVAEAAAAT REEEREARMN KSPSDFSCQS
     YEMFVGGQGA PPEGRSSLAG GGGPGGGNGH DGDYSIREKM SIKSDDVDSL LGGGNVSDSR
     MKINGRVRKV KFHPSLSLPG SPFAMRRASR GSHQFTWRNG PRRMGGANNN SSSADRKPLV
     LSTYLDAQEH LPYADDSAAV TPMSEDNGAI VVPPYALNNL GSRQASYTSH MSRMSYNSHG
     DLLNGKPPAM SGGGKDYRSA ANRVAAANAS SASRPTLVPD LVVEHSRHYH HHHHNQNHDY
     VMTSVLDHNA MDNPFIEQGQ KHAIADLKDA IAMHDMGPER MVQHHHHGEH REHRLHSHAV
     NEEDEGPKIK ERLLALSLKY LDVCCVWDCS PYWVSFQRLI SLFVYDAFIE LFITLCIVVN
     TLFMALDHHG MNEEMSRALK MGNYFFTATF AIEATFKLIA ISPKFYFREG WNIFDFIIVF
     LSLLELGLEG VSGLSVLRSF RLLRVFKLAK SWPTLNLLIS IMGKTVGALG NLTFVLCIII
     FIFAVMGMQL FGKNYIDNVD RFPNKELPRW HFMDFMHSFM IVFRVLCGEW VESMWDCMLV
     GDSTCIPFFL ATVVIGNLVV LNLFLALLLS SFGASNLSAP QVDNDTNKLT EAFNRISRFK
     RWVRRSFSNG FRMIRSKLTN QISDQRAPGE LPLFQIGPFY FQCGLFVFNF RASGMPAALH
     IRRHIEIVVK IAASCLFLIC DESMSKLKNK KGANNTSAVC PNSTKKRPDE LVLDIDCRKN
     PKDDDTISYQ SYGSHCHRIT RDESHKGSLR VDYYDEKRNA SKEDLDGFPE EARPAEVEGE
     DDGLAAEAAV VKIAHRVDSD EDPQYPDACF PDHWYEKIPI IKGNDDSPFW QGWAMLRLKT
     FRLIENKYFE TAVIIMILLS SLALALEDIY LSERPVLQDI LYYMDRIFTV IFFIEMLIKW
     LALGFKNYFT NAWCWLDFII VMVSLVNYVA SLFGGGKIQA FKTMRTLRAL RPLRALARFQ
     GMRVVVNALI QAIPSIFNVL LVCLILWLIF AIMGVQMFAG KYYKCVDAEG EIVSVEFVKN
     KTECIAKASS NYTWQNSPMN FDHVGKAYLS LFQVATFKGW MQIMRDATDS RDVDEQPKRE
     VNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED QKKYYSAMKK
     MGSKKPLKAI PRPQWRPQAI VFQIVTNKKF DMIIMLFIGL NMLTMTLDQY KPAQILSNIL
     DYLNMFFIVI FTAECSLKVF ALRHYYFKEP WNLFDFVVVI LSILGMVLSD LIEKYFVSPT
     LLRVVRVAKV GRVLRLVKGA KGIRTLLFAL AMSLPALFNI CLLLFLVMFI YAIFGMSFFM
     NVKHKSGIDE VYNFETFGKS MILLFQMSTS AGWDTVLEGI INEVECNLPN PETGDPGNCG
     QTTMGIAFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM YYEIWQQFDP
     EGTQYIRYDQ LPDFLDVLEP PLQIHKPNKY KIVSMDIPIC RGDLMYCVDI LDALTRDFFA
     RKGNPIEEPV EIDEAAQAIE RPGYDPVSST LWRQREEYCA RLIQNAWRRH REKPRGSTDG
     EGCSGAGSDT GCGGGAEHVS LAPSPSCISG VAGATGDSQH QQTAILIDSD GYATKNGHKV
     VIHSRSSSSI SSRSTDV
//
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