ID E9GGH2_DAPPU Unreviewed; 1021 AA.
AC E9GGH2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Integrin alpha second immunoglobulin-like domain-containing protein {ECO:0000259|Pfam:PF20805};
GN ORFNames=DAPPUDRAFT_303480 {ECO:0000313|EMBL:EFX81499.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX81499.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX81499.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR EMBL; GL732543; EFX81499.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GGH2; -.
DR STRING; 6669.E9GGH2; -.
DR EnsemblMetazoa; EFX81499; EFX81499; DAPPUDRAFT_303480.
DR KEGG; dpx:DAPPUDRAFT_303480; -.
DR eggNOG; KOG3637; Eukaryota.
DR HOGENOM; CLU_004111_5_0_1; -.
DR InParanoid; E9GGH2; -.
DR OMA; VEANFIS; -.
DR PhylomeDB; E9GGH2; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF83; INTEGRIN ALPHA-PS3-RELATED; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR PROSITE; PS51470; FG_GAP; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 42..60
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 958..981
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 69..138
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 368..431
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 433..491
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 585..688
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT REGION 996..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 112655 MW; 684A593B2C1C302D CRC64;
MAGFQEKRKK NYSAFTKGRK RCVSGATLGD FNSGSCKFSA RLFLWVMVCF VVGLVSSFNI
DTVHPLVYED PAAGQNARES YFGYSLQFLF NQKDNAHNSA KWLLVGAPRA NSTFPSHANL
KEPGQVYRCL LGNPNRDQCQ PLIVESEASQ FNRDRLYKDR KDYGWLGGAM AVNNPSTGRV
AVCGYRWSNS LSSTEHYMNG ACYWNNHQVS ENKDFVKVLP IVSKEQQVIG NDRNGTYNYA
YGQSGFSVHM ALKKDKIEEM IIGAPGVFKW TGAVIRVSDY SPDNPSGVPS RRKRQDTQDI
IEFGDTLVTN SAKISVLEPN DYFGYSVHSG IFFNDGKLLY VSGAPRAAGM KGKVLLFDFF
PGQDSQLNIR LELNGTQLGE YFGASVLAVD LTGDGKAELL VGAPQHSLQP ELGDRTGDEG
KVYFYLNRND NLERSPALFG SKAKDARFGT TMASVGDINR DGFNDVVIGA PYENDKGAVY
IYLGGMYDIH RHPETGYWQR IAAADFVFPL NNLKGFGISL VAADMDGNSY PGVGYNFHFD
AEYVNQPRLI LDIDEMKDTF CATCPVIDKT EKNYIEESAA FTSECGADNI CKEDLEVEAN
FISNLKELVI GSKSTISFEV KLVNHGEPSY LTTLDIQLPS YTNLKRTPAD LCQKPSFASS
EELIYSCQLR VNPLKRAKTE RMEFELDLMS VPSGGSDVLT VVVEARMNGV AAMGRQPLFN
LTMPLRTAID VEILGNSVEE QQTYQRSNET KVSAGLKDRI IFKHLYEVRN VLPSAAEVEI
EILIPNSVFS TQGVTLPVVE LPSISIDATQ KGGLSNTVCR LDYNSGQSID DIQRFREFIN
SSPTVKIQPP FKFGLVANRT AFIDCFNTPN ANCVKYICSA FGPLSTESPI RISLTGTLLL
QNIFSFMVNE DVFILSSAAR VVIRQPANNV PQPYGHKPDV AIATTYFLPQ GPPGTLAVAS
WIIVLAVLAG IILLSLMVVG LHKMGFFKRQ RYPQDGGLME ETTTPGDGNS EGTDTEPQPN
A
//
