ID E9GI64_DAPPU Unreviewed; 1045 AA.
AC E9GI64;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN ORFNames=DAPPUDRAFT_318220 {ECO:0000313|EMBL:EFX80623.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX80623.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX80623.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR EMBL; GL732546; EFX80623.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GI64; -.
DR STRING; 6669.E9GI64; -.
DR EnsemblMetazoa; EFX80623; EFX80623; DAPPUDRAFT_318220.
DR KEGG; dpx:DAPPUDRAFT_318220; -.
DR eggNOG; KOG1968; Eukaryota.
DR HOGENOM; CLU_003574_0_1_1; -.
DR InParanoid; E9GI64; -.
DR OMA; LICNERN; -.
DR PhylomeDB; E9GI64; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17752; BRCT_RFC1; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR036578}; Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 296..376
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 83..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..992
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 114437 MW; 3649899B57AA6DC0 CRC64;
MAPTTLLIVE SLETLFGHHA SQKSQNCCSQ GRHSKFFHVD RPEIVEITGF RLGRAYHETC
VLKENKSGRC TKEGAVVSAS KLKTNAKTPE TPLQPVDIGS VFGNKPIQRS KEIPEKRKRT
VIEDHSDEDF EATLQQLDEA PVTKKSKVVE KSTSKKGKTD SPTKKEKMKS PAKEEKSKPA
LHLKMRKHLQ KSQPGWNEEK DKRIKSQLKE LDSNSNKTSS TPKSNKKMKA ETTIVKETPK
KKSSKDDDDD DPDVIDSPAF DALEKRKEKA ENYRKFLASR RDGGAKNPGS KPVPEGAPGC
LTGLTIVVTG VLESLHREEA EGLVKKYGGK APKAVSKNTS YLLAGDDAGP SKLSKAKDLN
VPMLSEDDFL KLIATRPAGQ GLSSPAAKKA PTTPRSAHKA AASRKAEPEP PSKPITVSSP
PKKKSPEPKK IDLKPQQSSS TAAPIRKAEP ISVKMEVAEG NDQAQLPWVD KYKPTSLKQV
IGMHGDRSIA KKLVYWLKSW YDNRGKKLAK PSPWSTNDDG AFFKAALLSG PPGIGKTTTA
HLAAKELGYD LVEMNASDTR SKRLLHEHVM ELLSSQSLSS YAHGSAQIEG GRKRVLVMDE
VDGMAGNEDR GGIQELIAMI KTSKIPVVCI CNDRQHPKIR SLSNYCYDLK FTKPKIEQVR
GAMMSICFKE GLSLKPEALD EIIMGANQDV RQVLHHLSML ASGKKSLSTE SAKLEASKSK
KDLKLGPWDV VKKVFSAEEH KGMSIHDKTG LFFQDYSFGP LFVQENYPCV VPQAAKGNAI
KTLDLLGRTA HCMSQTDLIE KVIRSQNAWS LLPVEAVFAS VVPGQLMEGF ISSQIVFPSW
LGKNSRTNKM DRLLQELQTH MRLKISGSKR AVNLDYLPYV LNSIVGPLKR SGADGVSEAI
RAMESYDLMR EDLDSLLEVA QWPHKPDIMA GIEGKVKAAF TRAYNKEAHM TPYAAGQVKK
GRSKDTADDL EALDGDEDGL AGEEDDEEQS QDPSLDAMIK VKKESKKTAS SSSSSGATAA
ASRKKTGAPA ATRGRGRGGR KKAAE
//
