ID E9GL65_DAPPU Unreviewed; 803 AA.
AC E9GL65;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Calpain catalytic domain-containing protein {ECO:0000259|PROSITE:PS50203};
GN ORFNames=DAPPUDRAFT_304374 {ECO:0000313|EMBL:EFX79800.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX79800.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX79800.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL732550; EFX79800.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GL65; -.
DR STRING; 6669.E9GL65; -.
DR MEROPS; C02.029; -.
DR EnsemblMetazoa; EFX79800; EFX79800; DAPPUDRAFT_304374.
DR KEGG; dpx:DAPPUDRAFT_304374; -.
DR eggNOG; KOG0045; Eukaryota.
DR HOGENOM; CLU_006770_2_0_1; -.
DR InParanoid; E9GL65; -.
DR OMA; GDYRRGC; -.
DR PhylomeDB; E9GL65; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 2.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF04212; MIT; 2.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00745; MIT; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF116846; MIT domain; 2.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 223..529
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 278
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 447
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 467
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 803 AA; 90033 MW; BD8C8A4ED5AFDB94 CRC64;
MTSSGTTLQQ AIELGKRAVL LDQEGKHEGA AYFYEQAAIA LEEIVATNSI VQSATLAVKA
NQYKQRATSL RNSYLSSNVM PSLTEEQQSI LNNARNSVNK ALEVDEMGEH KKALPLYIDA
VEVCSSAAKA TSDKNLQSKL TKLAMQALNR AEELKMKPQT NKKTSASPAA SESAQVEHLS
VSNLKVSGAQ SYSSEEKKVL EITSMINGRE YVPFMAGDLQ ERFILLSTFS DRHGKLSLSP
KQKKSFSRWA RAEEISADPK VIENIDCFSI KQTVVSDCSF VASLAVSAQY EKRFNKKLIT
NIIYPQNKSG MPVYNSCGKY MIRLRINGVS RKVVIDDYLP MGRHGELLCS YSVNRNELWV
SLLEKAYMKV MGGYDFPGSN SNIDLHALTG WIPERVALKS SGGEEFKKEE LFKKLYDRFH
KGDVIVTVAT GEMSEAAEVR TGLVSAHAYA LLNIQEVKGI RLIMLKNPWS HVRWKGNYSE
LDANHWTEDL KKQLNYNPES AANFDNGVFW IDYDSLCTFF DVVYLSWNPS LFTHTFSIIG
CWNAGSGPVK DLYNIGENPQ FSLTVRSPGS AAVWILLTRH ITDIDDFREN KEYITVLVYK
NKGKRVYYPA DPPPYIDGIR INSPHYLCKL LHTQAGIERY TLVISQYEKS NTINYSLRVY
SSCPIELKKI TNPHRFKDEI RKDGWKGVSA GGCGNNPRTY PNNPKYQFTL EKTSDLLIDL
KGPKEFLIGF DVTCISLCDN DSSSGTFTKK SSGAFRSGFV ILELENVPAG IYQIVPSTFH
PGQEGSFFLT IQSPNQIKLK KIQ
//
