ID E9GME2_DAPPU Unreviewed; 867 AA.
AC E9GME2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
GN ORFNames=DAPPUDRAFT_319651 {ECO:0000313|EMBL:EFX79407.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX79407.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX79407.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL732552; EFX79407.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GME2; -.
DR EnsemblMetazoa; EFX79407; EFX79407; DAPPUDRAFT_319651.
DR KEGG; dpx:DAPPUDRAFT_319651; -.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_330710_0_0_1; -.
DR InParanoid; E9GME2; -.
DR OMA; LATIHIC; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15039; 7tmB3_Methuselah-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR022343; GCR1-cAMP_receptor.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR PANTHER; PTHR45902; LATROPHILIN RECEPTOR-LIKE PROTEIN A; 1.
DR PANTHER; PTHR45902:SF1; LATROPHILIN RECEPTOR-LIKE PROTEIN A; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR PRINTS; PR02001; GCR1CAMPR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..867
FT /note="G-protein coupled receptors family 2 profile 2
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003237588"
FT TRANSMEM 537..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 535..793
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 101..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96822 MW; C98238710AC549D1 CRC64;
MSKKRKILSS ISVFSFVFLV LLPDDCTSSL ATKLDLIHRE LASVNPAWTR VLNYILDSNQ
FNTNKDLGQQ TTTSQDNQEC CLTDHSGWWC RRRRQRHHHE GHLNPNHVDN NNSNSNLPSD
QLGHRSTRPA DLYEATDWHC PPAAAVVPTN RLMAEVVYSG EVDSSSRHHV ELPAIFSVLI
NFGNSEYYQF LISMLDYLEE DHGCSSGYVW DPFASACRRI YCSPGHVHGF QEDFCDYIDA
NETDTDWRMT YVMELEVIQL TLYVDAIYDS RNISDDDLLA IIQDSFAPVF AAFVGIDPGR
ITNLDVAFVN RTPKENKPAA PMMDQQRSLS IDFWLSQAED GSDEPTIDSV VALMGSLIVQ
DRLIAVIDGV VCQLVGLHEQ PVPSETDTFA NWCRGGITAI YHNDEFVIDV TSNNTETNQS
ELIVYIKATD QWYKSGEYMA DLFFYGSSNS SGLTSLSGSV AVCENRSVIE DTSCNVIHLN
QTEFVFFDNN TVLYNGSIPF IDPTLQPGEY ESLPDGGLAV CLYISQKWPV ALIVESYLTL
CLMSVSILAM MATIVTYLIF PELRNLAGLA VMNLCLMTSG FQLCIMIGMS LSVHQKSELC
VASAILVHYE GLASIFWTNV MAIDLFLTLG RWSAAPRKPS KILPRYSLYA YGLPLAIVSV
AVAINFCDCT GEFEVEYGKL FCWISNPTAN MVFFGLPLAL ALVANIVLFV RTVAIIYSSS
ACQGKQCSRR QRALCQLKLY ARMSTVMGFA WIFAFIAACF DPSSTAGMIF TFVYVILNSM
GGLFIFVAFT CNRRVYLLYR GWWARRRNQL LRRSSTTTAD SLSSTKTKAA PSVSHQSRQA
KTISVETLVS NSDAGDVSQN RETSLHM
//
