ID E9GPB3_DAPPU Unreviewed; 482 AA.
AC E9GPB3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Signal transducing adapter molecule 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_305142 {ECO:0000313|EMBL:EFX78711.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX78711.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX78711.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR EMBL; GL732556; EFX78711.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GPB3; -.
DR STRING; 6669.E9GPB3; -.
DR EnsemblMetazoa; EFX78711; EFX78711; DAPPUDRAFT_305142.
DR EnsemblMetazoa; XM_046597140.1; XP_046453096.1; LOC124200822.
DR KEGG; dpx:DAPPUDRAFT_305142; -.
DR eggNOG; KOG2199; Eukaryota.
DR HOGENOM; CLU_010104_0_0_1; -.
DR InParanoid; E9GPB3; -.
DR OMA; QVYRDWW; -.
DR OrthoDB; 620063at2759; -.
DR PhylomeDB; E9GPB3; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0033565; C:ESCRT-0 complex; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR CDD; cd21388; GAT_STAM; 1.
DR CDD; cd11820; SH3_STAM; 1.
DR CDD; cd03568; VHS_STAM; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF3; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 17..146
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 207..266
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 482 AA; 53621 MW; 32DEB7824BF9B663 CRC64;
MGIFSGSSPF DLDVEKATDE KNMSENWETI LDVCDKVKAI TTGPKDCLRA IIKRLYHQNP
HVAKQAVKLL DACVSNCHKP FHLEIASRDS EQELYKLIKN KLHPQVASQL KQCLKKWAEG
DFKTDSQLSL IPALYNRLRQ EGVDFTETTE PVKKTVVNNK DVAAREEEDI AKAIALSLKE
AEVTTKVSSS LYPSMTTSAP ISPVKERERR KVRALYDFEA AEDNELTFKA GEIIHVIDDS
DPNWWKGSNQ RGEGLFPANF VSTDLEAEPE VMVARDTSKR VQFNEQVVVA TLEETASSEA
EVEIDEAKID RMLHALHEAD PTGERNDPEE LKMLEDQCGA MGPLIDAELE KLDRRHAHLT
KLGSHLIESL DMYRSLMREM PAPPQTHPNM NMGMSVPGYQ YPGANVAPIG PVGGMNVSGN
MKYPFPQPQA PPQSPSLAPF APPVSHSATF PPNQVPNPMP YGVVNMGQQP FVNPYSGHPQ
NF
//
