ID E9GYH0_DAPPU Unreviewed; 992 AA.
AC E9GYH0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=NADPH oxidase 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_323294 {ECO:0000313|EMBL:EFX75389.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX75389.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX75389.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL732575; EFX75389.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GYH0; -.
DR STRING; 6669.E9GYH0; -.
DR EnsemblMetazoa; EFX75389; EFX75389; DAPPUDRAFT_323294.
DR KEGG; dpx:DAPPUDRAFT_323294; -.
DR eggNOG; KOG0039; Eukaryota.
DR HOGENOM; CLU_009773_0_0_1; -.
DR InParanoid; E9GYH0; -.
DR OMA; QWTTRLY; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0043020; C:NADPH oxidase complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016175; F:superoxide-generating NAD(P)H oxidase activity; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IBA:GO_Central.
DR GO; GO:0042554; P:superoxide anion generation; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF58; NADPH OXIDASE 5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR SFLD; SFLDS00052; Ferric_Reductase_Domain; 1.
DR SFLD; SFLDG01169; NADPH_oxidase_subgroup_(NOX); 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 374..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 215..250
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 251..286
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 579..692
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 992 AA; 113603 MW; 0C0CF63687DDAC2C CRC64;
MAKFASLDKV DSAFGIQIAE INANEPKETR KVAWFVQAQQ RQQALTGLQS LCKQRNEENT
ETFSADSFCR LFSQDNVLHL LFRLFDHHSR GKLVHSDFIG DLKEKLRPKT DFIDLLDTLW
YIFVKEDDID FEIFCRIFKS KGVLGKLFAL IDTDKAGAGQ VSVNQVMAVI TEYTSERRNL
HILYPGRAEE LFRSTVTNGN REMSFEDFKK LIPSKNKFFA ERIFRIFNKD GSKNLSIAEF
REGLEQFCGQ SEEDKVRCLF QIYDENGDGL IKLCELKSVL KACIEENGMK FSEKQVEELA
EALYDDARDR SDTSRHSTRN GLTYDELKAQ MSKHPGLLEN LSISLDRFLL PSPEKKTQRQ
PIFKPMVSYV KNNVPFVIFV LAYAIVNLGL FISRAIQYKD SNMFYILARS CGQTLNFNCA
FILVLMLRRG ITLLRNIGCG SFLPVDQHVY LHKVCGGVVV VLSALHILMH IINFPLNIAG
ELVSPVTNTS HSAAEWLFTM RPGLFGLYPG LANITGWALV VILAIMVICS LPSVRNSGYF
EVFYWTHLLY IPFWILLILH GPNFWYWFIG TGLCFALFKA SRRIKLSSSN RGCTDINSAM
LLPSRVTHLV IRKPENFYFH PGDYVYLKVP AITSTEWHPF TISSAPELPD FIWLHIRCAG
GWTNKLYEYF EQEQSKQLLR TNNVKNDNKK EPKAISAIEP TSVENDIRSK YKSHCIAMPS
GMPMHQQPCT ENVSLPIQIF KNSPLNPRKM KLTPRASHAP ETVAKDSVEI IQSHQPPMRE
ERHIFHSLEV AIDGPYGAPS SHIFRAEHAV LIAAGIGVTP FASILQSIMH RYYAIRQSCP
NCNHSWASQM PDSIMNLKKV DFFWINRDQR SFEWFVDMLS QLEMEQTDVG GVLDRFLDLH
MYITSALKKT DMKAVGLQMA FDLLYAKDKR DLVTGLKTRT NAGRPNWDKV FQKLVDEDKG
KVTVFYCGPP QLAKELRKKC NEFGFDFRKE IF
//
