ID E9GZJ5_DAPPU Unreviewed; 654 AA.
AC E9GZJ5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=DAPPUDRAFT_250988 {ECO:0000313|EMBL:EFX75004.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX75004.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX75004.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732578; EFX75004.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GZJ5; -.
DR STRING; 6669.E9GZJ5; -.
DR EnsemblMetazoa; EFX75004; EFX75004; DAPPUDRAFT_250988.
DR KEGG; dpx:DAPPUDRAFT_250988; -.
DR eggNOG; KOG3522; Eukaryota.
DR HOGENOM; CLU_027753_0_0_1; -.
DR InParanoid; E9GZJ5; -.
DR OMA; INCVERE; -.
DR PhylomeDB; E9GZJ5; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 151..346
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 69..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 72616 MW; 749C0AA47131BFE4 CRC64;
MKRKLSCTAI IDETQQCQYN YEAYGVGWKM SQHPPQLAGD CKCPPINASA SPTKGSCITP
LVRQNTWDSE TSHRQDMPTP LVSSAITSNH LPGGSADAET EAVAVITGDF TRKGRNSDPS
LTSQLSHPPL SGFLTSSPSN DSYPTSSDCD TRTHAIGELY DTERSYVESL QILVTKYLQP
LKGPECSGLV ESNLVDEIFF QIPAILVHHE VFLEELRKRL ESWDSKQCVG GVFLDTYTLR
NMSLTKPSVI ETYTAYINHW KHAKEAIKTA CLAKSAFSKF LEATAREHKG KLALDSLLIM
PVQRIPRYEL LIKMLLKHTP REHPDHTLLL DAQREVHELA VKINCVEREA YGAEQQQATL
RELESLVEGL GPGNLATPER TFIRHDCVTI PSALGTRKER GFFLFSDLLV ITSVKRRSAA
IRKSSSYSSS GIASTLEANK FKLLMRVPLD DLEVTKNKED SSKRTTKDLE HIEEDLALLN
QITELVSSLH VSHSSLDEAI KEIQLGIQRQ LADKQNASTE PQLATLDLAI CTRDGIETLS
VAFTTSEKRA SWEESFSETK LKLRAMSPER RPPPEFLMSL PIRKTRAGLQ FTCAAPTVTW
NTQHLNDVWV CNSDGYVGQV CILSLHPEPN VTSCNGVCNA RITCIAAIPA APLM
//
