ID E9H248_DAPPU Unreviewed; 1066 AA.
AC E9H248;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=ATP-dependent RNA helicase YTHDC2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_307460 {ECO:0000313|EMBL:EFX74196.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX74196.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX74196.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732585; EFX74196.1; -; Genomic_DNA.
DR AlphaFoldDB; E9H248; -.
DR STRING; 6669.E9H248; -.
DR EnsemblMetazoa; EFX74196; EFX74196; DAPPUDRAFT_307460.
DR KEGG; dpx:DAPPUDRAFT_307460; -.
DR eggNOG; KOG0920; Eukaryota.
DR HOGENOM; CLU_001832_1_6_1; -.
DR InParanoid; E9H248; -.
DR PhylomeDB; E9H248; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 43..205
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 387..557
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1066 AA; 119257 MW; E3B4E0B67380746D CRC64;
MNRIAGRLNL SDKPPYIPLF GESAVFVHHR RNLPIFKYRQ EILNQLECQQ VVVIAGNVGC
GKTTQVPQYI LENAYEKKGA CRIISIQPRR LSVHAALDRV IAERGKLVGH QTRLESKGTV
NCPLIFCTTG VFLRSLIEND RCLKGITHVI IDQVHERDRF TDLLLGVFRL RLSQYPDLRL
ILLSADMAPH ALANYFHQEK IIRVPVSSTP VSQLFLEDIL TCTKFLSKQK LLTGAGGVKG
ELTLGPANVF DDLITEAWYN GSDLIFLHIM KLVRDGAMPI DYQHSQTGIT VLMACANHGK
LDIVKMAISL GADPTLQVKG MTSYDLANEF ARPEVADLLL SYSQVFYNEV GNNVVIQEPL
TVNYNSPDDV LKSFYAKYSQ DHANLDLIIE VLNYVQGYSQ PGTILVLLPA YSEVVELRDM
IIASTSSLKN KLEVHTLHGH LFPNDFKKIF CPAPADKRKV ILSTNIAETS ISFDDVICVI
DSGLFRDREN DVVFTNPKKT QWISKASAAQ RVMHVRNGGI VFHLYPRSTL DGLQEYPVPE
ITRDPLIDVC LFARLIIPED MRLPQFFCSL PDGPPTTAVH QAIEILESID AFDSQSKVTD
VGLRLIDLSV EPRLGKILLV SVGLRCLDPV LTIICCLARD DPFITPVSPD ERKVAIMRRY
DLAPDYLSDH LALLRAYHLW EKGNDEGRKR QVCQENYLSV ANIELVFLLR VLLVGELRAS
GYVRSRGSAD IRNLNIHSES WTAIKAALTS GLYPNLARYS PTDGGIITQN ETRSQFHFTS
TLLVQEGRNN GLGFVAASSA DSLPWVIFED QQRAGQFTVL RCCSVVTPIT ALLFAGHLGS
EIQTVQLNQD ILGLNRVAKS NKRLSRPRKH FVILKIDEFI GFVVDSYVAQ LIMNTRKKFQ
TILAKCIREP GRNCSVGEDG VLRTVLSLLS SEEMAMQVPQ PSGVGRRPTN VSADSMLVTP
ELKPEELYPI RRYMAYTPPP KGYSYESHEY NNSFVTSGMG STASKNRIKP NRLNKTTDYR
EVFPNPTPVP SMNLSFQGMP SVMPNVTPVR GRPLCKSYSY NYSEGN
//