ID E9H2A0_DAPPU Unreviewed; 654 AA.
AC E9H2A0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Groucho-like protein {ECO:0000313|EMBL:EFX74135.1};
GN Name=GRO2 {ECO:0000313|EMBL:EFX74135.1};
GN ORFNames=DAPPUDRAFT_299755 {ECO:0000313|EMBL:EFX74135.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX74135.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX74135.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; GL732585; EFX74135.1; -; Genomic_DNA.
DR AlphaFoldDB; E9H2A0; -.
DR STRING; 6669.E9H2A0; -.
DR EnsemblMetazoa; EFX74135; EFX74135; DAPPUDRAFT_299755.
DR KEGG; dpx:DAPPUDRAFT_299755; -.
DR eggNOG; KOG0639; Eukaryota.
DR HOGENOM; CLU_007612_3_1_1; -.
DR InParanoid; E9H2A0; -.
DR OMA; ISAPACY; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814:SF21; TRANSCRIPTION FACTOR UNC-37; 1.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 4..112
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 417..443
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 454..495
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 496..537
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 578..609
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 111..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 12..39
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 136..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFX74135.1"
SQ SEQUENCE 654 AA; 70799 MW; DD890177FB3E3A2E CRC64;
GQPFKFTINE SCDRIKEEFS FLQAQYHNLK LECEKLASEK IEIQRHYVMY YEMSYGLNVE
MHKQTEIAKR LNAIIAQVLP FLSQEHQQQV ASAVERAKQV TMTELNAVIG RNSISPTERE
KYRNARSPMS SGDPHAPDMK KIKREDKDGH MSDGERSDQD LVVDDGGDDP ITPPSRNHSP
RENGVDKSKK DHNSSHRCVW LLLGGHMMNK GKHDVDKNNG AAGIAPKPAT PTGLGGIPPP
GPPGGKGVPK PSPLGQYPPY MPPGGPPPDM AGVAGPYGPP PMHAGYPPRP MLAYDTHPQM
RGPLGSMSQG GGKPAYSFHV GGDGVVQPVP FPPDALVGPG IPRAARPLST LPHGEVVCAV
TISSPTKYVY TGGKGCVKVW DISQFFGSGG QSNGSMNGSK SPIPVSQLDC LQRDNYIRSV
KLLPDGRTLI VGGEASTLSI WDLAAPTPRI KAELTSSAPA CYALAISPDS KVCFSCCSDG
NIAVWDLHNQ TLVRQFQGHT DGASCIDMSA DGTRLWTGGL DHTVRSWDLR EGRQLAQHDF
ASQIFSLGYC PAGDWLAVGL ESSTVEVLHT LKPDKYQLHL HESCVLSLKF AATGKWFVST
GKDNLLNAWR TPYGASIFQS KESSSVLSCD VSSDDKYIVT GSGDKKATVY EVIY
//