ID   E9H731_DAPPU            Unreviewed;      1316 AA.
AC   E9H731;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=Tetratricopeptide repeat protein 21B {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DAPPUDRAFT_326178 {ECO:0000313|EMBL:EFX72446.1};
OS   Daphnia pulex (Water flea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX72446.1, ECO:0000313|Proteomes:UP000000305};
RN   [1] {ECO:0000313|EMBL:EFX72446.1, ECO:0000313|Proteomes:UP000000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21292972; DOI=10.1126/science.1197761;
RA   Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA   Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA   Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA   Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA   Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA   Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA   Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA   Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA   Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA   Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA   Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA   Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT   "The ecoresponsive genome of Daphnia pulex.";
RL   Science 331:555-561(2011).
CC   -!- SIMILARITY: Belongs to the TTC21 family.
CC       {ECO:0000256|ARBA:ARBA00010935}.
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DR   EMBL; GL732599; EFX72446.1; -; Genomic_DNA.
DR   STRING; 6669.E9H731; -.
DR   EnsemblMetazoa; EFX72446; EFX72446; DAPPUDRAFT_326178.
DR   KEGG; dpx:DAPPUDRAFT_326178; -.
DR   eggNOG; ENOG502QQAB; Eukaryota.
DR   HOGENOM; CLU_006149_0_0_1; -.
DR   InParanoid; E9H731; -.
DR   OMA; NATCVRA; -.
DR   PhylomeDB; E9H731; -.
DR   Proteomes; UP000000305; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:GOC.
DR   GO; GO:0030991; C:intraciliary transport particle A; IBA:GO_Central.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14699:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG; 1.
DR   Pfam; PF14559; TPR_19; 2.
DR   Pfam; PF13174; TPR_6; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 13.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          717..750
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          884..917
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1316 AA;  149208 MW;  75F82295E39BA585 CRC64;
     MEDKNMEVKI HSLFREQLYH SAAEATNSTD NSVNTLNKFY QALALLFTNK VEDALNLLTP
     LQADPLLNLS AIIASLHIYK HFKSIDAGET ITQLEAALRS ERKKASDKSL YYAALFLHLN
     NRQEKAREYA ERALSINSGS NNIDGIILKG WIELLSNRDK SKKKNPLEYF ESAISIESRA
     IEAYQGKIRY LIQSDNVSQA FPILNQMISN YPNNQEFLVE KLRAHLAAKD WDAVGDLTKK
     INNVPNPFIV KILEIQILAT ICHDGSFVDA TPLLKKLFLA LEKYEPTNGE LFVNSARLFS
     RVCGRHIPIL NECQVFVEKA IRLDEKNFNY LFELAQQQVL QGRFKDALSS LKKISQSGET
     SIEVMLLKIH CLLDDEQYEA AQQQLNIVEE LHDNASSRTT FLLAKAMLLR QRDPTESLHL
     LKLAYQLQVK NTSCISYGVE YLNHLNPDYL LSVAEEYFQY HGPEDSPQTL LELSDILTCV
     VQACPGLLPA LYRLANANFI AGDYRAASAT LHHIIDHVDP TYIEAYLLMA QIGIYQNNLA
     QAAQHLEMGL SYNFHVRDHP RYHLLLAKVQ RLKKDTDACL SSIRMAMILS GMRPSSAGMK
     RSKYPFSLGE KAATYLELFH VLMDSNQKED AGQVIQEALQ ELKGTSQEGV VILAQVDHLL
     NEGDIDGALL KLKALPDSHP QHLQAREKMA DIYLHRLQDE ALYLQCYRDI VRQLPTVRNL
     TLLGDAHLAL HQVDQAVLAY EDALKLEPRN FQLASKIGAA LVLTHQYTKA LNYFKDALRS
     DDSSSHPGLR IEYATLLSRL GQLDKAEKII SEALLPNIQQ ARGDPDRLMQ EVKLLQLLAK
     VQEKSGDQEE AIASLRRCQS IIGSLVKKVD QSDHLIEQKK IASTISIQMA GHALSVDRDT
     DAAIRLYREA LSYSPDDVHC MAQLAKVYLQ TNDVEHCQYM CKSLLKIDRE NDQAQMMVAQ
     IALRKNDLET ATLHFRQALE RQPCHYEMLG QFIDVCRRRG NISDANVTLL FRSAEVNSVH
     GQNEPGLSYC RGLYEFYSGQ YNVALLALNR ARGHAVWGQY AIRIMLDICL NGDSETLENV
     TDLDSQYEVQ DTELMALHTA AKLLQELSMV EGDELQTHVL YPNLYLLATR QKTNVERALI
     DLTTFATKSN QQDNPGVVFG IATAHLLLKQ AQRARNQLKR LIKAPWTLEE GEYLERCWLL
     LSDIYIQAGQ NKMEVANELL RRVLTYNRSC AKAYEYLGYI MEKEQSFREA AGHFENAWKM
     SDQSNGMVGY KLALSYLKAK QYTDAIDISQ SVLTKYPNHP RIRKDVLEKA IANLRS
//