ID E9HKL0_DAPPU Unreviewed; 598 AA.
AC E9HKL0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Rho GTPase-activating protein 39 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_301804 {ECO:0000313|EMBL:EFX67738.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX67738.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX67738.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732669; EFX67738.1; -; Genomic_DNA.
DR AlphaFoldDB; E9HKL0; -.
DR STRING; 6669.E9HKL0; -.
DR EnsemblMetazoa; EFX67738; EFX67738; DAPPUDRAFT_301804.
DR KEGG; dpx:DAPPUDRAFT_301804; -.
DR eggNOG; ENOG502QR6X; Eukaryota.
DR HOGENOM; CLU_005171_1_1_1; -.
DR InParanoid; E9HKL0; -.
DR OMA; KQMPTGE; -.
DR PhylomeDB; E9HKL0; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04389; RhoGAP_KIAA1688; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF8; FI04035P; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 43..70
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 237..395
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 406..593
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 79..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 67440 MW; 506225D48314130D CRC64;
MEWVEIIEPR TKEHMYANLT TGECVWDPPP GVSVKRTTDN QWWELFDHKT SRFYYYNAAT
QRTVWHRPPN CDIIPLAKLQ SSRPSSGGGG SVSAMTGTGT QTCSTSPPLA QLSAQQQQQR
KVRRGTSHGG WYNRHGKSQD SGRSSDSSTL SLSKRSDKLG SSAGSGPLGG SSLTSPLRGT
PSSGRRPTLD PPPLEFGIGS TASTPLSSRK KGSGGSSGGG GGGLFRKNLS IRDMLSWSKD
PIRKPMLPLE DKTLKKEACD LFKLVQIYMG DRKCKPGMTC NSVALELCNH AWNKPALRDE
LYLHVCRQTT ENPRKESLRR GWELMAVCLY FFPPSPKLEP YLDGYINRHR DPGLNFTEVQ
VSHYATISCR RLMRIGAAGR RHERKPTLEE IEQARLQIFR PSMFGNTLEE IMMVQRDRFP
HRKLPWIQTT LSEEILRLQG AQTEGIFRVP ADVDEVNSLK NRMDQWELCP VSDAHVPASL
LKLWYRELYE SLIPDELYQD CVQYCADPER AVAIVHRLPE FHRLVLSYLI RFLQIFSQTE
VSSVTKMDAS NLAMVMAPNC LRCNASDPKV IFDNARKEMA FIRTLIQHLD TSFMEGVV
//
