ID E9HT89_DAPPU Unreviewed; 679 AA.
AC E9HT89;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN ORFNames=DAPPUDRAFT_65729 {ECO:0000313|EMBL:EFX65054.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX65054.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX65054.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|ARBA:ARBA00006459,
CC ECO:0000256|RuleBase:RU003732}.
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DR EMBL; GL732766; EFX65054.1; -; Genomic_DNA.
DR AlphaFoldDB; E9HT89; -.
DR EnsemblMetazoa; EFX65054; EFX65054; DAPPUDRAFT_65729.
DR KEGG; dpx:DAPPUDRAFT_65729; -.
DR eggNOG; KOG3659; Eukaryota.
DR HOGENOM; CLU_006855_7_2_1; -.
DR InParanoid; E9HT89; -.
DR OMA; ILVSICN; -.
DR PhylomeDB; E9HT89; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR CDD; cd10332; SLC6sbd-B0AT-like; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR PANTHER; PTHR11616:SF182; TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 84..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 74853 MW; E3ED623BB1C3DD5F CRC64;
MFLNGSETGA DGSHQQSLRP PHHRGQTSAG GVSSEGPATS GGPSLLPSGV ATAAGHNKSS
VVNDAVLHVP ELLPPERQKW DNKLQFMLSA IGYSVGLGNV WRFPYLVQQN GGGAFLIPFF
VMLLLEGIPL FLVELALGQK LRQGSLGAWN LIHPWLGGLG IASTLVAFLV GLYYNVIITW
CFYYLFNSFQ SPLPWSTCPI DSNGTAVKEC TAATETAYFW YRTALDISPS VDQPEGIKWW
MALCLLLSWI IVYFITMRGI QSSGKVVYFT ALFPYAVLTI FFIRGITLKG AGAGLAHMLQ
PQMHKLLDPT VWLDAATQVF YSFNIGFGSL IAFGSYNPPR NNCVKDTLIL SVCNAATAVY
ASVVIFAILG FKAVRSYDLC VNQSVIISLH SIFKIIDNFL TDEAYANFLQ YRDESKDLGL
RGCNLEEIMN ESVEGTGLVF IVFTQAIVEL PAAPFWAILF FLMLLALGVG SQIGTLEGVI
STVFDIQIVR GARKEVVSAA VCIVSYLIGL LFVTGSGEYW VKIFDSFAGT TGLIFIALLE
SVAVMYIYGH RKFSQDILQM TGHMPGPYWQ ITWRFVGPVL ISVLLVASII YRSFDKPAYY
AWNAQEGKSF LTPYPQWVLI VGGLLATLSV LPIPAVFLLR RFQFLRLDTD INKGVIRRNE
TTISTKQMMT DVDVSFLKK
//
