ID E9HTS0_DAPPU Unreviewed; 486 AA.
AC E9HTS0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_304228 {ECO:0000313|EMBL:EFX64852.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX64852.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX64852.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732783; EFX64852.1; -; Genomic_DNA.
DR AlphaFoldDB; E9HTS0; -.
DR STRING; 6669.E9HTS0; -.
DR EnsemblMetazoa; EFX64852; EFX64852; DAPPUDRAFT_304228.
DR KEGG; dpx:DAPPUDRAFT_304228; -.
DR eggNOG; KOG4406; Eukaryota.
DR HOGENOM; CLU_030214_1_0_1; -.
DR InParanoid; E9HTS0; -.
DR OMA; PTRVREY; -.
DR PhylomeDB; E9HTS0; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:2001136; P:negative regulation of endocytic recycling; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 110..265
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 294..484
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 55866 MW; 9927C0542493B239 CRC64;
MNRDSPSKPR SAIPAYLTGE TEDPYPSLSD IHDYEPNLEF DDTELQQPVD DEGEIIGIGI
ESDEFLETPV SDGTIEENFE EAFGLPSLIP EYPSLIPEQR DSLKELDVDD FIDVAQHRIV
DVVGDDTYGR KVIVVSACRL PSNKVLDHNR LLSYLMHTLD NYVETDYTVV YFHHGLNSQN
KPSFRWLLQA YRAFDRKYKK NLKALYLVHP TNFIRVIWQL FKPFISIKFG RKMMYVNYLS
ELGNHIHLNQ VNIPPPVLTH DAQLMSKIAN KSGQGSQVDS SSYVQPLPTQ QFGVTLQFIK
ERNNGQVIPP VVSRCVEFLS QPDALETEGL FRRSASVSLV RDVQSRINRG ESIDFQRDFP
CDYHLAAVTL KTFLRELKEP LMTFDLFDDI INFQRLNKEE RAQMVKTLIL ERLPEDNYIL
LKYLAQFLAK VQDRSDLNKM TSFNLAVVFG PNLVWSQNQQ MSLSAIGPIN ALTEHILSHY
LEIFIL
//
