ID E9HV92_DAPPU Unreviewed; 443 AA.
AC E9HV92;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFX64342.1};
GN ORFNames=DAPPUDRAFT_334303 {ECO:0000313|EMBL:EFX64342.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX64342.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX64342.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732844; EFX64342.1; -; Genomic_DNA.
DR AlphaFoldDB; E9HV92; -.
DR STRING; 6669.E9HV92; -.
DR EnsemblMetazoa; EFX64342; EFX64342; DAPPUDRAFT_334303.
DR KEGG; dpx:DAPPUDRAFT_334303; -.
DR eggNOG; KOG0807; Eukaryota.
DR eggNOG; KOG3379; Eukaryota.
DR HOGENOM; CLU_030130_12_1_1; -.
DR InParanoid; E9HV92; -.
DR OMA; GWHNKKR; -.
DR PhylomeDB; E9HV92; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0047710; F:bis(5'-adenosyl)-triphosphatase activity; IBA:GO_Central.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IBA:GO_Central.
DR CDD; cd01275; FHIT; 1.
DR CDD; cd07572; nit; 1.
DR Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR019808; Histidine_triad_CS.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR045254; Nit1/2_C-N_Hydrolase.
DR InterPro; IPR001110; UPF0012_CS.
DR PANTHER; PTHR23088:SF27; DEAMINATED GLUTATHIONE AMIDASE; 1.
DR PANTHER; PTHR23088; NITRILASE-RELATED; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
DR PROSITE; PS00892; HIT_1; 1.
DR PROSITE; PS51084; HIT_2; 1.
DR PROSITE; PS01227; UPF0012; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 8..257
FT /note="CN hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS50263"
FT DOMAIN 296..404
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 389..393
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 391
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 322
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 378
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 393
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT SITE 409
FT /note="Important for induction of apoptosis"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-3"
SQ SEQUENCE 443 AA; 49385 MW; 8ABE93AD0820B766 CRC64;
MTDSSKPSLI AIVQMTATSN KADNFAVTKE KIEEASSLGA KVVFLPEACD YIADSHAQSL
ELAENMDGTL IKNYSELAVQ NRIWISIGGF HNKSSSIDKM FNTHVLINSD GQIAGRYDKT
HLFDVEIPEK KIKLKESDYI EKGGSIASPV ESPVGKIGLG ICYDVRFPEF SLSLARMGAD
IITYPSAFTV ATGLAHWESI LRARAIETQC FVVAAAQTGI HNSKRSSYGH AMVIDPWGTV
IAQCREGTSL ALAAIDLEYL RKVRREMPVF THRRQDVYQL PTCGVLPVSP LPPDEATFNF
GQVTIKGWAV FYQSRHSLAF VNRKCVVPGH VLVMPLKASR RIPDMQPDEL SDLFLTSQIV
QRGMELFHGV SSSNVAVQDG PDAGQSIQHV HVHILPRRPK DFKENDQVYD ELNNHDKGPN
VEWRQEEEMK REATELRLFF AKL
//
