ID E9I1D9_DAPPU Unreviewed; 675 AA.
AC E9I1D9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Rac GTPase-activating protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_270847 {ECO:0000313|EMBL:EFX62190.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX62190.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX62190.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL733767; EFX62190.1; -; Genomic_DNA.
DR AlphaFoldDB; E9I1D9; -.
DR STRING; 6669.E9I1D9; -.
DR EnsemblMetazoa; EFX62190; EFX62190; DAPPUDRAFT_270847.
DR KEGG; dpx:DAPPUDRAFT_270847; -.
DR eggNOG; KOG3564; Eukaryota.
DR HOGENOM; CLU_026187_1_0_1; -.
DR InParanoid; E9I1D9; -.
DR OMA; CRKKWLR; -.
DR PhylomeDB; E9I1D9; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0097149; C:centralspindlin complex; IBA:GO_Central.
DR GO; GO:0032154; C:cleavage furrow; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; IBA:GO_Central.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR CDD; cd04382; RhoGAP_MgcRacGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199:SF3; FI24033P1-RELATED; 1.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 365..414
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 435..623
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 210..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 82..137
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 286..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 76006 MW; 7CAAB0F37E10F0A2 CRC64;
MEILYNISDE KERREHVRAH PCPAAANVMF TRDRFPLAMS AKQVSVLAQY DDLCRGFNYF
VNSSEKEFLK FAVNQEACRQ KWLEAEAELK RLHNQLNDVN KMNGKLELQY HHATVLLKNE
IKVRKQVSDE KKSLEKQLYI VREIVSAEKD IRDETREKLA MLSNTGRYSR GNFDSPGDRL
NTINELNSTG SLLASFDLTT ERTEEELELS VMRSSRAPRG KRTSEGMYNL DNSKRYKASS
NRENIMEVSG HERVVATTTV TVSKGGPITA TSIIENHPDM GRENDISNAT PKNQRKRSSS
EPGIIPNAPP QYLIESSWEL PDGKTPVAIR RPSANPSASA HSTHTLGGTA YLRTMASGGR
INQRQHTFSQ KTIIKPENCL PCGNRIKFGK PALKCVECRG TCHVDCKSRM PMPCVPTVQT
PSNKGFVGTV ADYAPNISPM IPGIVIHCVN EIERRGLTEV GIYRVNGSEK EIKDMKERLL
RGKGQPTLSQ IDIHVVTGTL KLFFRSLKEP LITYTLWDSF VRIAELADEM DIQTTVYSLV
PDLPQPNRDT LAYVILHLQR VAEAEVCKMP ITNLARIFGP TIIGYSCPDP LPEMALKQLK
KQHLICRANT CVVMQLQTME RLLLIPSDYW ARYVDVETET FTSTPVSSHR HPGVATIAKN
VKRGPTFFSS PNMMN
//
