ID E9PDJ4_HUMAN Unreviewed; 503 AA.
AC E9PDJ4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Dedicator of cytokinesis 8 {ECO:0000313|Ensembl:ENSP00000417691.2};
GN Name=DOCK8 {ECO:0000313|Ensembl:ENSP00000417691.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417691.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000417691.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2] {ECO:0007829|PubMed:19369195}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [3] {ECO:0007829|PubMed:20068231}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [4] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6] {ECO:0000313|Ensembl:ENSP00000417691.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL158832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E9PDJ4; -.
DR MassIVE; E9PDJ4; -.
DR MaxQB; E9PDJ4; -.
DR PeptideAtlas; E9PDJ4; -.
DR ProteomicsDB; 19678; -.
DR Ensembl; ENST00000483757.6; ENSP00000417691.2; ENSG00000107099.18.
DR UCSC; uc064rul.1; human.
DR HGNC; HGNC:19191; DOCK8.
DR VEuPathDB; HostDB:ENSG00000107099; -.
DR GeneTree; ENSGT00940000155876; -.
DR HOGENOM; CLU_033132_0_0_1; -.
DR ChiTaRS; DOCK8; human.
DR Proteomes; UP000005640; Chromosome 9.
DR Bgee; ENSG00000107099; Expressed in bone marrow cell and 168 other cell types or tissues.
DR ExpressionAtlas; E9PDJ4; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF74; DEDICATOR OF CYTOKINESIS PROTEIN 8; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:E9PDJ4,
KW ECO:0007829|MaxQB:E9PDJ4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 2..98
FT /note="Dedicator of cytokinesis C/D N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11878"
SQ SEQUENCE 503 AA; 57113 MW; B24E34BCE0662939 CRC64;
MTHLNSLDVQ LAQELGDFTD DDLDVVFTPK ECRTLQPSLP EEGVELDPHV RDCVQTYIRE
WLIVNRKNQG SPEICGFKKT GSRKDFHKTL PKQTFESETL ECSEPAAQAG PRHLNVLCDV
SGKGPVTACD FDLRSLQPDK RLENLLQQVS AEDFEKQNEE ARRTNRQAEL FALYPSVDEE
DAVEIRPVPE CPKEHLGNRI LVKLLTLKFE IEIEPLFASI ALYDVKERKK ISENFHCDLN
SDQFKGFLRA HTPSVAASSQ ARSAVFSVTY PSSDIYLVVK IEKVLQQGEI GDCAEPYTVI
KESDGGKSKE KIEKLKLQAE SFCQRLGKYR MPFAWAPISL SSFFNVSTLE REVTDVDSVV
GRSSVGERRT LAQSRRLSER ALSLEENGVG SNFKTSTLSV SSFFKQEGDR LSDEDLFKFL
ADYKRSSSLQ RRVKSIPGLL RLEISTAPEI INCCLTPEML PVKPFPENRT RPHKEILEFP
TREVYVPHTV YSPWPLNLHI QRN
//
