ID E9PFR9_HUMAN Unreviewed; 512 AA.
AC E9PFR9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Spermatogenesis associated 13 {ECO:0000313|Ensembl:ENSP00000386471.1};
GN Name=SPATA13 {ECO:0000313|Ensembl:ENSP00000386471.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386471.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000386471.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000386471.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL136963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001273722.1; NM_001286793.1.
DR AlphaFoldDB; E9PFR9; -.
DR SMR; E9PFR9; -.
DR MassIVE; E9PFR9; -.
DR MaxQB; E9PFR9; -.
DR PeptideAtlas; E9PFR9; -.
DR ProteomicsDB; 20162; -.
DR Antibodypedia; 49852; 108 antibodies from 23 providers.
DR DNASU; 221178; -.
DR Ensembl; ENST00000409126.5; ENSP00000386471.1; ENSG00000182957.16.
DR GeneID; 221178; -.
DR UCSC; uc010tdb.4; human.
DR CTD; 221178; -.
DR HGNC; HGNC:23222; SPATA13.
DR VEuPathDB; HostDB:ENSG00000182957; -.
DR GeneTree; ENSGT00940000154103; -.
DR HOGENOM; CLU_008436_2_1_1; -.
DR OrthoDB; 20491at2759; -.
DR BioGRID-ORCS; 221178; 17 hits in 1151 CRISPR screens.
DR ChiTaRS; SPATA13; human.
DR GenomeRNAi; 221178; -.
DR Proteomes; UP000005640; Chromosome 13.
DR Bgee; ENSG00000182957; Expressed in epithelial cell of pancreas and 191 other cell types or tissues.
DR ExpressionAtlas; E9PFR9; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:E9PFR9,
KW ECO:0007829|PeptideAtlas:E9PFR9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 69..128
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 144..284
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 315..421
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 512 AA; 58977 MW; E9AB245CD3F4C77A CRC64;
MVARGEIARF WSLESLHLVS SDGGTEPSAL VDDNGSEEDF SYEDLCQASP RYLQPGGEQL
AINELISDGN VVCAEALWDH VTMDDQELGF KAGDVIQVLE ASNKDWWWGR SEDKEAWFPA
SFVRGYIRQC RKHTGMFTVA QLATIFGNIE DIYKFQRKFL KDLEKQYNKE EPHLSEIGSC
FLQNQEGFAI YSEYCNNHPG ACLELANLMK QGKYRHFFEA CRLLQQMIDI AIDGFLLTPV
QKICKYPLQL AELLKYTTQE HGDYSNIKAA YEAMKNVACL INERKRKLES IDKIARWQVS
IVGWEGLDIL DRSSELIHSG ELTKITKQGK SQQRTFFLFD HQLVSCKKDL LRRDMLYYKG
RLDMDEMELV DLGDGRDKDC NLSVKNAFKL VSRTTDEVYL FCAKKQEDKA RWLQACADER
RRVQEDKEMG MEISENQKKL AMLNAQKAGH GKSKGYNRCP VAPPHQGLHP IHQRHITMPT
SVPQQQVFGL AEPKRKSSLF WHTFNRLTPF RK
//
