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Database: UniProt
Entry: E9PM12_HUMAN
LinkDB: E9PM12_HUMAN
Original site: E9PM12_HUMAN 
ID   E9PM12_HUMAN            Unreviewed;       217 AA.
AC   E9PM12;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   25-APR-2018, entry version 48.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE   Flags: Fragment;
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSP00000435023};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435023, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435023, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000435023}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AP002807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; E9PM12; -.
DR   PRIDE; E9PM12; -.
DR   Ensembl; ENST00000529657; ENSP00000435023; ENSG00000110719.
DR   UCSC; uc058ell.1; human.
DR   EuPathDB; HostDB:ENSG00000110719.9; -.
DR   HGNC; HGNC:11647; TCIRG1.
DR   OpenTargets; ENSG00000110719; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   ChiTaRS; TCIRG1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110719; -.
DR   ExpressionAtlas; E9PM12; baseline and differential.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|EPD:E9PM12,
KW   ECO:0000213|MaxQB:E9PM12, ECO:0000213|PeptideAtlas:E9PM12};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    114       {ECO:0000256|SAM:Coils}.
FT   NON_TER     217    217       {ECO:0000313|Ensembl:ENSP00000435023}.
SQ   SEQUENCE   217 AA;  24341 MW;  254F5DECA9870B35 CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE
     LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRA
     QLHQLQLHAA VLRQGHEPQL AAAHTDGASE RTPLLQAPGG PHQDLRVNFV AGAVEPHKAP
     ALERLLWRAC RGFLIASFRE LEQPLEHPVT GEPATWM
//
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