ID E9PN63_HUMAN Unreviewed; 330 AA.
AC E9PN63;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Family with sequence similarity 86 member B1 {ECO:0000313|Ensembl:ENSP00000432931.1};
GN Name=FAM86B1 {ECO:0000313|Ensembl:ENSP00000432931.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432931.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000432931.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000432931.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. EEF2KMT family. {ECO:0000256|ARBA:ARBA00005511}.
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DR EMBL; AC145124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006716319.1; XM_006716256.3.
DR AlphaFoldDB; E9PN63; -.
DR SMR; E9PN63; -.
DR MassIVE; E9PN63; -.
DR MaxQB; E9PN63; -.
DR PeptideAtlas; E9PN63; -.
DR ProteomicsDB; 22319; -.
DR Antibodypedia; 76809; 6 antibodies from 6 providers.
DR DNASU; 85002; -.
DR Ensembl; ENST00000533852.7; ENSP00000432931.1; ENSG00000186523.15.
DR GeneID; 85002; -.
DR UCSC; uc064kix.1; human.
DR CTD; 85002; -.
DR HGNC; HGNC:28268; FAM86B1.
DR VEuPathDB; HostDB:ENSG00000186523; -.
DR GeneTree; ENSGT00510000047003; -.
DR OMA; ECDISHE; -.
DR OrthoDB; 49253at2759; -.
DR PhylomeDB; E9PN63; -.
DR BioGRID-ORCS; 85002; 704 hits in 1048 CRISPR screens.
DR GenomeRNAi; 85002; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; E9PN63; Protein.
DR Bgee; ENSG00000186523; Expressed in right uterine tube and 96 other cell types or tissues.
DR ExpressionAtlas; E9PN63; baseline and differential.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029426; FAM86_N.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF117; PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT-RELATED; 1.
DR Pfam; PF14904; FAM86; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 7..98
FT /note="FAM86 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14904"
SQ SEQUENCE 330 AA; 36787 MW; 6AB85808D9192A2B CRC64;
MAPEENAGTE LLLQGFERRF LAVRTLRSFP WQSLEAKLRD SSDSELLRDI LQKTVRHPVC
VKHPPSVKYA WCFLSELIKK HEAVHTEPLD KLYEVLTETL MAKESTQGHR SYLLSSGGSV
TLSKSTAIIS HGTTGLVTWD AALYLAEWAI ENPAAFINRT VLELGSGAGL TGLAICKMCR
PRAYIFSDPH SRVLEQLRGN VLLNGLSLEA DITGNLDSPR VTVAQLDWDV AMVHQLSAFQ
PDVVIAADVL YCPEAIVSLV GVLQRLAACR EHKRAPEVYV AFTVRNPETC QLFTTELGRD
GIRWEAEAHH DQKLFPYGEH LEMAMLNLTL
//
