ID E9PPT7_HUMAN Unreviewed; 259 AA.
AC E9PPT7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 9.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Latent transforming growth factor beta binding protein 3 {ECO:0000313|Ensembl:ENSP00000436341.2};
GN Name=LTBP3 {ECO:0000313|Ensembl:ENSP00000436341.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436341.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000436341.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000436341.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AP000769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E9PPT7; -.
DR MassIVE; E9PPT7; -.
DR PeptideAtlas; E9PPT7; -.
DR ProteomicsDB; 22815; -.
DR Antibodypedia; 70903; 14 antibodies from 10 providers.
DR Ensembl; ENST00000532661.6; ENSP00000436341.2; ENSG00000168056.18.
DR UCSC; uc058dlg.1; human.
DR HGNC; HGNC:6716; LTBP3.
DR VEuPathDB; HostDB:ENSG00000168056; -.
DR GeneTree; ENSGT00940000160285; -.
DR ChiTaRS; LTBP3; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000168056; Expressed in descending thoracic aorta and 191 other cell types or tissues.
DR ExpressionAtlas; E9PPT7; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF00683; TB; 1.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57581; TB module/8-cys domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51364; TB; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|MaxQB:E9PPT7,
KW ECO:0007829|PeptideAtlas:E9PPT7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 39..79
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 92..142
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT REGION 144..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 259 AA; 28440 MW; 518EBB63676E9FB5 CRC64;
MLFGSEICKE GKCVNTQPGY ECYCKQGFYY DGNLLECVDV DECLDESNCR NGVCENTRGG
YRCACTPPAE YSPAQRQCLS PEEMERAPER RDVCWSQRGE DGMCAGPLAG PALTFDDCCC
RQGRGWGAQC RPCPPRGAGS HCPTSQSESN SFWDTSPLLL GKPPRDEDSS EEDSDECRCV
SGRCVPRPGG AVCECPGGFQ LDASRARCVD IDECRELNQR GLLCKSERCV NTSGSFRCVC
KAGFARSRPH GACVPQRRR
//
