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Database: UniProt
Entry: E9PT83_RAT
LinkDB: E9PT83_RAT
Original site: E9PT83_RAT 
ID   E9PT83_RAT              Unreviewed;      2985 AA.
AC   E9PT83;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   12-AUG-2020, entry version 65.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSRNOP00000004525};
GN   Name=Cenpf {ECO:0000313|Ensembl:ENSRNOP00000004525,
GN   ECO:0000313|RGD:628667};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000004525, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000004525, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004525,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000004525}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004525};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; AABR07022106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10116.ENSRNOP00000004525; -.
DR   iPTMnet; E9PT83; -.
DR   PhosphoSitePlus; E9PT83; -.
DR   jPOST; E9PT83; -.
DR   PaxDb; E9PT83; -.
DR   PRIDE; E9PT83; -.
DR   Ensembl; ENSRNOT00000004525; ENSRNOP00000004525; ENSRNOG00000003388.
DR   RGD; 628667; Cenpf.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; E9PT83; -.
DR   OMA; YNAQLVQ; -.
DR   TreeFam; TF101133; -.
DR   Reactome; R-RNO-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR   Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-RNO-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-RNO-68877; Mitotic Prometaphase.
DR   Reactome; R-RNO-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000003388; Expressed in testis and 19 other tissues.
DR   GO; GO:0005930; C:axoneme; ISO:RGD.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0000775; C:chromosome, centromeric region; ISO:RGD.
DR   GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR   GO; GO:0097539; C:ciliary transition fiber; ISO:RGD.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0000776; C:kinetochore; ISO:RGD.
DR   GO; GO:0030496; C:midbody; ISO:RGD.
DR   GO; GO:0005635; C:nuclear envelope; ISO:RGD.
DR   GO; GO:0016363; C:nuclear matrix; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0045120; C:pronucleus; ISO:RGD.
DR   GO; GO:0005819; C:spindle; ISO:RGD.
DR   GO; GO:0000922; C:spindle pole; ISO:RGD.
DR   GO; GO:0070840; F:dynein complex binding; ISO:RGD.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; ISO:RGD.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   GO; GO:0008134; F:transcription factor binding; ISO:RGD.
DR   GO; GO:0007059; P:chromosome segregation; ISO:RGD.
DR   GO; GO:0001822; P:kidney development; ISO:RGD.
DR   GO; GO:0051310; P:metaphase plate congression; ISO:RGD.
DR   GO; GO:0000278; P:mitotic cell cycle; ISO:RGD.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0015031; P:protein transport; ISO:RGD.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; ISO:RGD.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; ISO:RGD.
DR   GO; GO:0021591; P:ventricular system development; ISO:RGD.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN          1..302
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1879..2020
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2116..2255
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2298..2437
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2840..2884
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          254..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          761..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1105..1136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2767..2917
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2935..2985
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          161..188
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          275..323
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          331..405
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          518..645
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          652..700
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          712..753
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          833..860
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          893..927
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          931..951
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          963..997
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1023..1078
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1197..1245
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1294..1321
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1326..1346
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1537..1600
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1612..1632
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1777..1804
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1875..1895
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1945..1982
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2008..2056
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2092..2119
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2127..2241
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2309..2413
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2460..2480
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2488..2522
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2540..2581
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2596..2697
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2707..2734
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2742..2762
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        471..488
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1105..1124
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2767..2832
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2870..2917
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2938..2952
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2985 AA;  341740 MW;  FFB64DF8A9AC2EF2 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVEDGKT
     EGADLKRENQ RLMEICENLE KTRQKLSHEL QVKESQVNFQ ESQLSSCKKQ IEKLEQELKR
     CKSEFERSQQ SAEVSLNPCS TPQKLFTTPL TPSQYYICST YEDLKEKYNK EVEDRKRLEA
     EVKALHAKKA SLPVSQATMN HRDIARHQAS SSVFSWQQDK TPSRLSSCSL RTPLRRDVSA
     AHFLGEEVTP NKSSVQIGRG DCSGLPDDPH CSQPLHQAKA QNQELKSKMN ELELRLRGQE
     KEMKDQVNKF QELQLQLEKT KVDLIEKEKI LNKTRDEVVR TTAQYEQAAA KCTALEQKLK
     NLTEELSCHR QNAESAKRSL EQRVKEKEKE LREELSRQHQ SFQALDHEYT QMKTRLTQEL
     QQAKHSLSVL QLELEKVTSV KQQLERSLEE IRHKFSRAEQ ALQASQLTEN ELRRSSEEMK
     KENSLIRSQS EQRTREACRL EDELGKVKVC LSQSQSFAEE MRAKNTSQEI MLRDLQEKLN
     QQENSLTLEK LKLALADLEG QRDCSQDLLK KREHHIEQLN DKLNKIEKEF ETLLSALELK
     KKECEELKEE KNQISCWKSE NEKLINQIES EKEILLGKVN HLEASLKTQQ ISHDYSERVR
     TLEMERENLT VEIRNLHSLL DSKMVEIETQ KQAYLELQQQ SESSDQKHQK EMENMCLKAN
     KLTGQVESLE CKLQSLSGEV ETKDQQYQDL RMEYETMRDS LQARGSSLVT DEKNQRSSSA
     FEEQPAVSHS FANLVGEKGS IYSERSDSSV DRGQSPENVA VLQSRVTLLE SSLESQNQMN
     SDLQKQCEEL LQIKGEIEEN LIKADQIHQN FVAETNQRIG KLQEDAAVHQ NIVAETLATL
     ESREKELQLL KEQLEAQQTE VQKLEKNNCL LEGALKELQL LTDTLSSEKK EMNSIISLRK
     KDIEELTQAN GALKEVNEAL RQEKMNLLQQ HEEITRCVAE GERSIAELSG QYKQERLLLL
     QRCEETETVL EGLRGDYKAA QENNAKLECM LSECTALCEN KKNELEQLKE TFAKEQQEFL
     TKLAFTEEQN RKLVLELETE PQTVRSEITN INKHPVSETD ALGQESWSSK EEQKEKQKEV
     SNLTPENEQL MELTQTKHDY YHLEVEPVEN SVKATEEEIR KSSSQYQMDI DTKDISLDSY
     KAQLVQLEAL IKVMEVKLDR SEEEKNSLRQ ELQTIREELG TKTSQDTQSQ ARVGLKDCEV
     EAEEKYVSVL QELSTSQNEN VHLQCSLQTA MNKLNELGKM CEVLRVEKLQ LESELNDSRS
     ECITATSQMA AEVEKLVNEM KMLNHENALS HGELMKDTAD VEFDDKPNHT SVFLTPLDNS
     EQMTSSNKEV RVHFAELQEK FSCLQSEHKI LHDQHCEVSS KMSALRSYVD TLKAENSVLS
     MNLRTLQGDL VKEKEPGAED GHILPLSFCR TDSPTLTNFG ENSFYKDVLE QTGDTSHLSL
     EGNASANPCD VDEVSYSSLE EENLTEKEIP FASLRTVEEL EILCQVYLQS IKNLEEKIES
     QRIMKNKEIE ELEQLLSSER KELSCLRKQY LSEKEQWQQK LTSVTLEMES KLAEEKQQTK
     NLSLELEVAR LQLQELDLSS RSLLGTDLEG AVRGPNDGYA IKESEVYISE TTEKTPKQDT
     NQTCDNDVQQ DLCLETSVTE TETTRLTGDG CEEQPSKISC EAPAEDRTQD YSECISELFS
     TPSVLVPMDV LEDQGSIQNL HLQKDTSNEN LRLLPEVEDW DKKVESLLNE IKEADSKLSL
     QELQLKIKIA TCIELEKIVK HLKKEETDLS EKLESLPCNQ EVCPRVERSD LDFNLDMGDD
     ELFRESTKDD AANTEDNYKE KFLDMERELT RIKSEKANIE HHIVSVKANL EVVQAEKLCL
     ERDTESKQKV IVDLKGELFT VISERNRLRE ELDNVSKESK ALDQMSKKMK EKIEELESHQ
     RESLHHIGAV ESEVKDKAEL IQTLSFSVDE LTKDKAHLQE QLQNLQNDSQ GLSLAIGELE
     IQIGQLNKEK ESLVKESQNF QVKLTESECE KQTISKALEV ALMEKGEFAM RLSSTQEEVH
     QLRQGIEKLS VRIEADEKKH LSAVAKLKES QRESDSLKDK VENLERELEM SEENQELAIL
     DSENLKAEVE TLKAQMDEMA KSLRVFELDL VNVRSERENL AKQLQEKQSR VSELDELCSS
     LRSLSEEKEQ ARVQMERDSK SAMLMLQTQL KELWEEVAAL YNDQETLKAQ EQSLDQPGEE
     VHLLKSSIQK LKVHIDADKK KQCHILEQLK ESKHHADLFK DRVENLEQEL MLSEKNKEHL
     IFQAENSKAE IQTLKTEIQT MDQNLQDLEL ELTNTRSEKE NLMKELKNEQ EQISKLETIN
     SSIERLLKDK EAEXVQVKEE ARITVEMLQT QLKGSNETGG SLCNDQEAYK TKEQNLGSRV
     QTLELEKAQL LQDLGEAKNK YIIFQSSVNA LTQEVEAGKQ KLEKEEEEVR TLKEQLKGQE
     QLVCKLARVE GEQQLCQKQK LELRSLTMEL EQKVKVLQSE NDALQTTYEA LQSSYKSLEG
     ELGLIKMEKM ALVERVNTMT GKEAELQREL HDVEQKSTQL KEEYSKEKTR LTEDLEVVME
     ELKNTKVAHL KNVNHLEKEF QRAQGKIKLL LKSCKQLEGE KKMLQKELSQ LEAAQKQRAG
     SLVDSNVDEL MTENKELKET LEEKIKEADK YLDKYCSLLI SHEELEKTKE ILEIQVARLS
     SRQNKQDLQS SPLLDSSVAG PSPSTSVSER KSTSGLNKTL GKRQRSSGIG ENGNGTAPST
     PETFSKKSRK SVSNSAHPAE DEEETEFEPE GLPEVVKKGF ADIPTGKTSP YILRRTTMAT
     RTSPRLAAQK LLGSSPTLGK ENLVESSKPT AGGSRSQKVK VVQESSMDAH AVFQELPAKS
     LTANNMPGRN STESPREGLR AKRACPASSP AAGPDPMNNE NCRVQ
//
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