ID E9PWT1_MOUSE Unreviewed; 3858 AA.
AC E9PWT1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|Ensembl:ENSMUSP00000091668.3};
GN Name=Trrap {ECO:0000313|Ensembl:ENSMUSP00000091668.3,
GN ECO:0000313|MGI:MGI:2153272};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000091668.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000091668.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000091668.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000091668.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000091668.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR SMR; E9PWT1; -.
DR EPD; E9PWT1; -.
DR jPOST; E9PWT1; -.
DR MaxQB; E9PWT1; -.
DR PeptideAtlas; E9PWT1; -.
DR ProteomicsDB; 351488; -.
DR Antibodypedia; 16027; 203 antibodies from 23 providers.
DR Ensembl; ENSMUST00000094120.9; ENSMUSP00000091668.3; ENSMUSG00000045482.17.
DR AGR; MGI:2153272; -.
DR MGI; MGI:2153272; Trrap.
DR VEuPathDB; HostDB:ENSMUSG00000045482; -.
DR GeneTree; ENSGT00390000017961; -.
DR PhylomeDB; E9PWT1; -.
DR ChiTaRS; Trrap; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000045482; Expressed in yolk sac and 262 other cell types or tissues.
DR ExpressionAtlas; E9PWT1; baseline and differential.
DR GO; GO:0051173; P:positive regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:E9PWT1,
KW ECO:0007829|MaxQB:E9PWT1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 2691..3274
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3499..3822
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3826..3858
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 489..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2542..2577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..526
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3858 AA; 437223 MW; B384575CDD10E45E CRC64;
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE NVTSSPQYST
FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEILHRI PTNEHLRPHT KNVLSVMFRF
LETENEENVL ICLRIIIELH KQFRPPITQE IHHFLDFVKQ IYKELPKVVN RYFENPQGIP
ENTVPPPEMV GMITTVAVKV NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK
LNIHNVVAEF VPLIMNTIAI QVSTQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC MDKLFDESIL
IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ LFAKNIDDES LPSSIQTMSC
KLLLNLVDCI RSKSEQESGN GRDVLMRMLE VFVLKFHTIA RYQLSAIFKK CKPQSELGAA
EAALPGVPTA PAAPGPAPSP APVPAPAPPP PPPPAPATPV TPAPVPPFEK QGEKDKEDKQ
TFQVTDCRSL VKTLVCGVKT ITWGITSCKA PGAQFIPNKQ LQPKETQIYI KLVKYAMQAL
DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI FQTTVPYMVE
RISKNYALQI VANSFLANPT TSALFATILV EYLLERLPEM GSNVELSNLY LKLFKLVFGS
VSLFAAENEQ MLKPHLHKIV NSSMELAQTA KEPYNYFLLL RALFRSIGGG SHDLLYQEFL
PLLPNLLQGL NMLQSGLHKQ HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT
LVSQGLRTLE LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG
SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL KSANTEPYYR
RQAWEVIRCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN VIISHRYKAQ DTPARKTFEQ
ALTGAFMSAV IKDLRPSALP FVASLIRHYT MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE
ENGSKGMDPL VLIDAIAICM AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY
IVERLCACCY EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN
GAVAMAKTTL EQLLMRCATP LKDEERAEEI VLAQEKSFHH VTHDLVREVT SPNSTVRKQA
MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ PANAQIGLME GNTFCTTLQP
RLFTMDLNVV EHKVFYTELL NLCEAEDSAL TKLPCYKSLP SLVPLRIAAL NALAACNYLP
QSREKIIAAL FKALNSTNSE LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL
TLNVVNRLTS VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NESLSECGRC
SLSPFCQFEE MKICSAIINL FHLIPAAPQT LVKPLLEVVM KTERAMLIEA GSPFREPLIK
FLTRHPSQTV ELFMMEATLN DPQWSRMFMS FLKHKDARPL RDVLAANPNR FITLLLPGGA
QTAVRPGSPS TSNMRLDLQF QAIKIISIIV KNDDAWLASQ HSLVSQLRRV WVSETFQERH
RKENMAATNW KEPKLLAFCL LNYCKRNYGD IELLFQLLRA FTGRFLCNMT FLKEYMEEEI
PKNYSIAQKR ALFFRFVEFN DPNFGDELKA KVLQHILNPA FLYSFEKGEG EQLLGPPNPE
GDNPESITSV FITKVLDPEK QADMLDSLRI YLLQYATLLV EHAPHHIHDN NKNRNSKLRR
LMTFAWPCLL SKACVDPACK YSGHLLLAHI IAKFAIHKKI VLQVFHSLLK AHAMEARAIV
RQAMAILTPA VPARMEDGHQ MLTHWTRKII VEEGHTVPQL VHILHLIVQH FKVYYPVRHH
LVQHMVSAMQ RLGFTPSVTI EQRRLAVDLS EVVIKWELQR IKDQQPDSDM DPNSSGEGVN
SVSIKRGLSV DSAQEVKRFR AATGAISAVF GRSQSLPGAD SLLAKPIDKQ HTDTVVNFLI
RVACQVNDNT NTAGSPGEVL SRRCVNLLKT ALRPDMWCKS ELKLQWFDKL LMTVEQPNQV
NYGNICTGLE VLNFLLTVLQ SPAILSSFKP LQRGIAACMT CGNTKVLRAV HSLLSRLMSI
FPTEPSTSSV ASKYEELECL YAAVGKVIYE GLTNYEKATS ANPSQLFGTL MILKSACCNN
PSYIDRLISV FMRSLQKMVR EHLNPQTASG STEATAAGTS ELVMLSLDLV KTRLAVMSME
MRKNFIQTIL TSLIEKSPDA KILRAVVKIV EEWVKNNSPM AANQTPTLRE KSILLVKMMT
YIEKRFPEDL ELNAQFLDLV NYVYRDEALS GSELTAKLEP AFLSGLRCAQ PLIRAKFFEV
FDNSMKRRVY ERLLYVTCSQ NWEAMGSHFW IKQCIELLLA VCEKSTAIGT SCQGAMLPSI
TNVINLADSH DRAAFAMVTH VKQEPREREN SESKEEDVEI DIELAPGDQT STPKTKELSE
KDIGNQLHML TNRHDKFLDT LREVKTGALL SAFVQLCHIS TTLAEKTWVQ LFPRLWKILS
DRQQHALAGE ISPFLCSGSH QVQRDCQPSA LNCFVEAMSQ CVPPIPMRPC VLKYLGKTHN
LWFRSTLMLE HQAFEKGLSL PIKPKQTTEF YEQESITPPQ QEILDSLAEL YSLLQEEDMW
AGLWQKRCKF SETATAIAYE QHGFFEQAQE SYEKAMDKAK KEHERSNASP AIFPEYQLWE
DHWIRCSKEL NQWEALTEFG QSKGHINPYL VLECAWRVSN WTAMKEALVQ VEVSCPKEMA
WKVNMYRGYL AICHPEEQQL SFIERLVEMA SSLAIREWRR LPHVVSHVHT PLLQAAQQII
ELQEAAQINA GLQPTNLGRN NSLHDMKTVV KTWRNRLPIV SDDLSHWSSV FMWRQHHYQG
KPTWSGMHSS SIVTAYENSS HHDPSSNNAM LGVHASASAI IQYGKIARKQ GLVNVALDIL
SRIHTIPTVP IVDCFQKIRQ QVKCYLQLAG VMGKNECMQG LEVIESTNLK YFTKEMTAEF
YALKGMFLAQ INKSEEANKA FSAAVQMHDV LVKAWAMWGD YLESIFVKER QLHLGVSAIT
CYLHACRHQN ESKSRKYLAK VLWLLSFDDD KNTLADAVDK YCIGVPPIQW LAWIPQLLTC
LVGSEGKLLL NLISQVGRVY PQAVYFPIRT LYLTLKIEQR ERYKSDPGPI RATAPMWRCS
RIMHMQRELH PTLLSSLEGI VDQMVWFREN WHEEVLRQLQ QGLAKCYSVA FEKSGAVSDA
KITPHTLNFV KKLVSTFGVG LENVSNVSTM FSSAASESLA RRAQATAQDP VFQKLKGQFT
TDFDFSVPGS MKLHNLISKL KKWIKILEAK TKQLPKFFLI EEKCRFLSNF SAQTAEVEIP
GEFLMPKPTH YYIKIARFMP RVEIVQKHNT AARRLHIRGH NGKIYPYLVM NDACLTESRR
EERVLQLLRL LNPCLEKRKE TTKRHLFFTV PRVVAVSPQM RLVEDNPSSL SLVEIYKQRC
AKKGIEHDNP ISRYYDRLAT VQARGTQASH QVLRDILKEV QSNMVPRSML KEWALHTFPN
ATDYWTFRKM FTIQLALIGF AEFVLHLNRL NPEMLQIAQD TGKLNVAYFR FDINDATGDL
DANRPVPFRL TPNISEFLTT IGVSGPLTAS MIAVARCFAQ PNFKVDGVLK TVLRDEIIAW
HKKTQEDTSS PLSAAGQPEN MDSQQLVSLV QKAVTAIMTR LHNLAQFDGG ESKVNTLVAA
ANSLDNLCRM DPAWHPWL
//
