ID E9PXQ7_MOUSE Unreviewed; 1057 AA.
AC E9PXQ7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Protocadherin 10 {ECO:0000313|Ensembl:ENSMUSP00000131073.2};
GN Name=Pcdh10 {ECO:0000313|Ensembl:ENSMUSP00000131073.2,
GN ECO:0000313|MGI:MGI:1338042};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000131073.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000131073.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131073.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000131073.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131073.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001091640.1; NM_001098170.1.
DR AlphaFoldDB; E9PXQ7; -.
DR SMR; E9PXQ7; -.
DR STRING; 10090.ENSMUSP00000131073; -.
DR SwissPalm; E9PXQ7; -.
DR MaxQB; E9PXQ7; -.
DR PaxDb; 10090-ENSMUSP00000131073; -.
DR ProteomicsDB; 355055; -.
DR Antibodypedia; 2468; 185 antibodies from 26 providers.
DR DNASU; 18526; -.
DR Ensembl; ENSMUST00000166126.7; ENSMUSP00000131073.2; ENSMUSG00000049100.16.
DR GeneID; 18526; -.
DR KEGG; mmu:18526; -.
DR UCSC; uc008pda.1; mouse.
DR AGR; MGI:1338042; -.
DR CTD; 57575; -.
DR MGI; MGI:1338042; Pcdh10.
DR VEuPathDB; HostDB:ENSMUSG00000049100; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000158277; -.
DR HOGENOM; CLU_006480_1_1_1; -.
DR InParanoid; E9PXQ7; -.
DR OMA; FPLEMIV; -.
DR OrthoDB; 4259465at2759; -.
DR PhylomeDB; E9PXQ7; -.
DR TreeFam; TF352008; -.
DR BioGRID-ORCS; 18526; 4 hits in 76 CRISPR screens.
DR ChiTaRS; Pcdh10; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; E9PXQ7; Protein.
DR Bgee; ENSMUSG00000049100; Expressed in substantia nigra and 138 other cell types or tissues.
DR ExpressionAtlas; E9PXQ7; baseline and differential.
DR Genevisible; E9PXQ7; MM.
DR GO; GO:0005886; C:plasma membrane; ISS:MGI.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IDA:MGI.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IDA:MGI.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF0; PROTOCADHERIN-10; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:E9PXQ7,
KW ECO:0007829|PeptideAtlas:E9PXQ7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1057
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003244305"
FT TRANSMEM 714..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..122
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 123..250
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 251..358
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 359..463
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 464..574
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 590..680
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 207..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..924
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1057 AA; 115000 MW; 30D34C83B6F3EC51 CRC64;
MIVLLFFALL WMVDGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA RRFQTVANSR
TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE NPLELFRVEI EVLDINDNPP
SFPEPDLTVE ISESATPGTR FPLESAFDPD VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF
AELVLEKPLD REQQAVHRYV LTAVDGGGGG GGGEGGGGGG GAGLPPQQQR TGTALLTIRV
LDSNDNVPAF DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL
FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD ANDNAPEISF
STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD VPFRLKSSFK NYYTIVTEAP
LDREAGDSYT LTVVARDRGE PALSTSKSIQ VQVSDVNDNA PRFSQPVYDV YVTENNVPGA
YIYAVSATDR DEGANAKLTY SILECQIQGM SVFTYVSINS DNGYLYALRS FDYEQIKDFS
FQVEARDAGS PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL
TRVAAVDADD GENARLTYSI VRGNEMNLFR LDWRTGELRT ARRVPAKRDP QRPYELVIEV
RDHGQPPLSS TATLVVQLVD GAVEPQGGGG DRGGGSGEHL RPSRSGGGET SLDLTLILII
ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT CLASDCCLCC CCCGNGSSTC CGRQARARKK
KLSKSDIMLV QSANVPSNPA QVPVEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC
SPSRSTDAEH NPCGAIVTGY SDQQPDIISN GSILSNENKH QRAELSYLVD RPRRVNSSAF
QEADIVSSKD SGHGDSEQGD SDHDVTNRGQ SAGMDLFSNC TEECKALGHS DRCWMPSFVP
SDGRQAADYR SNLHVPGMDS VPDTEVFEPP EVQPGAERSF STFGKEKALH GTLERKELDG
LLSNTRAPYK PPYLKMLWMQ LRGEAHLTKD GGKQTTT
//
