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Database: UniProt
Entry: E9PZZ1
LinkDB: E9PZZ1
Original site: E9PZZ1 
ID   PRD13_MOUSE             Reviewed;         754 AA.
AC   E9PZZ1; B1AV74;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   RecName: Full=PR domain zinc finger protein 13;
DE            EC=2.1.1.-;
DE   AltName: Full=PR domain-containing protein 13;
GN   Name=Prdm13;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=E9PZZ1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=E9PZZ1-2; Sequence=VSP_042506;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AL672159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS38699.1; -. [E9PZZ1-1]
DR   RefSeq; NP_001074240.1; NM_001080771.1. [E9PZZ1-1]
DR   UniGene; Mm.208541; -.
DR   ProteinModelPortal; E9PZZ1; -.
DR   SMR; E9PZZ1; -.
DR   STRING; 10090.ENSMUSP00000092761; -.
DR   PhosphoSitePlus; E9PZZ1; -.
DR   PaxDb; E9PZZ1; -.
DR   PeptideAtlas; E9PZZ1; -.
DR   PRIDE; E9PZZ1; -.
DR   Ensembl; ENSMUST00000076206; ENSMUSP00000075562; ENSMUSG00000040478. [E9PZZ1-2]
DR   Ensembl; ENSMUST00000095141; ENSMUSP00000092761; ENSMUSG00000040478. [E9PZZ1-1]
DR   GeneID; 230025; -.
DR   KEGG; mmu:230025; -.
DR   UCSC; uc008sco.1; mouse. [E9PZZ1-1]
DR   CTD; 59336; -.
DR   MGI; MGI:2448528; Prdm13.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00940000160200; -.
DR   HOGENOM; HOG000049198; -.
DR   HOVERGEN; HBG053667; -.
DR   InParanoid; E9PZZ1; -.
DR   OrthoDB; 1318335at2759; -.
DR   TreeFam; TF106398; -.
DR   PRO; PR:E9PZZ1; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000040478; Expressed in 8 organ(s), highest expression level in neural tube ventricular layer.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0042054; F:histone methyltransferase activity; IDA:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0022008; P:neurogenesis; IDA:MGI.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Methyltransferase; Nucleus; Reference proteome; Repeat;
KW   S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW   Transferase; Zinc; Zinc-finger.
FT   CHAIN         1    754       PR domain zinc finger protein 13.
FT                                /FTId=PRO_0000416115.
FT   DOMAIN       39    160       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     185    207       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     620    642       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     648    670       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     677    700       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    312    383       Gly-rich.
FT   COMPBIAS    384    398       His-rich.
FT   COMPBIAS    482    487       Poly-Gly.
FT   COMPBIAS    538    557       Ala-rich.
FT   COMPBIAS    602    610       Poly-Gly.
FT   VAR_SEQ       1     48       Missing (in isoform 2). {ECO:0000305}.
FT                                /FTId=VSP_042506.
SQ   SEQUENCE   754 AA;  78705 MW;  82E2B2E3B109C37B CRC64;
     MPAHVTPRTE DARRGAGPSS ACGCSWFCHL RPVEDPASPS VCLAAVATMH GTSRTSATSV
     NADCCIPAGL RLGPVPGTFK LGKYLSDRRE PGPKKKVRMV RGELVDESGG SPLEWIGLIR
     AARNPQEQTL EAIADLPGGQ IFYRALRDVQ PGEELTVWYS NSLAQWFDIP TTATPTHDEK
     GEERYICWYC WRTFRYPNSL KAHLRFHCVL SGGGGRAFLP QEHAARPGAS PVAEGLGLPP
     KPTVPDLTAP VQAIALRPQA PAAQLAQACG ARESIKREAS LAPLATSPPP GKWGTPKKGK
     EQPDRAHSQF LGIVGGSSGG GGGLPFYPGV RSAFKPAGLA RAAAQSDPYR EEGGGKGPGL
     ALGRLLGGGR AGGRPGSGES PAGHHHHHHH AHHHHHHHPK CLLAGEPPPA GLPCPGALRA
     FPLLAGHPEE ASAFKHVERA PPAAATTSLP SARYAALPAP GLPVERCALQ PLDGGSLKAY
     PGGGGGGECS PLPAVMPAFT VYSGDLLYGP PAAYYPLKLH LGGLLKYPES ISYLSGPAAA
     AAAAAAAAAA AAAIGPAELG SLASIDREIA MHTQQLSEMA AGKSRARLDS GTLPPAVVAA
     TGPGGGGGGG SAAGKPKTGH LCLYCGKLYS RKYGLKIHMR THTGYKPLKC KVCLRPFGDP
     SNLNKHIRLH AEGNTPYRCE FCGKVLVRRR DLERHVKSRH PGQSLMAKAG DGPGPEPSYA
     LEPGDPKSED SDVDVCFTDD QSDPEAGGRG EHDS
//
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