ID E9Q0D4_MOUSE Unreviewed; 1826 AA.
AC E9Q0D4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=SET binding factor 2 {ECO:0000313|Ensembl:ENSMUSP00000126217.2};
GN Name=Sbf2 {ECO:0000313|Ensembl:ENSMUSP00000126217.2,
GN ECO:0000313|MGI:MGI:1921831};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000126217.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000126217.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000126217.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000126217.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000126217.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR SMR; E9Q0D4; -.
DR jPOST; E9Q0D4; -.
DR MaxQB; E9Q0D4; -.
DR ProteomicsDB; 318668; -.
DR Antibodypedia; 24321; 52 antibodies from 11 providers.
DR Ensembl; ENSMUST00000166020.8; ENSMUSP00000126217.2; ENSMUSG00000038371.16.
DR AGR; MGI:1921831; -.
DR MGI; MGI:1921831; Sbf2.
DR VEuPathDB; HostDB:ENSMUSG00000038371; -.
DR GeneTree; ENSGT00940000155385; -.
DR ChiTaRS; Sbf2; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000038371; Expressed in paneth cell and 267 other cell types or tissues.
DR ExpressionAtlas; E9Q0D4; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13339; PH-GRAM_MTMR13; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037823; MTMR13_PH-GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Proteomics identification {ECO:0007829|MaxQB:E9Q0D4,
KW ECO:0007829|PeptideAtlas:E9Q0D4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 7..381
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1060..1561
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1720..1824
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1651..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1826 AA; 205025 MW; 21EA60DC808C68C0 CRC64;
MARLADYFIV VGYDHEKPAG PGEGLGKIIQ RFPQQDWDDT PFPQGIELGT KKEEIEGEEV
SGLIQPAEVF APKSLVLVSR LDYPEIFRAC LGLIYTVYVD SMSVSLESLI ANLCACLVPA
AGGSQKLFSL GAGDRQLIQT PLHDSLPVTG TSVALLFQQL GIQNVLNLFC AVLTENKVLF
HSASFQRLSD ACRALESLMF PLKYSYPYIP ILPAQLLEVL SSPTPFIIGV HSIFKTDVHE
LLDVIIADLD GGTIKIPECI HLSSLPEPLL HQTQSALSLI LHPDLEVADH AFPPPRTALS
HSKMLDKEVR AVFLRLFAQL FQGYRSCLQL IRIHAEPVIH FHKTAFLGQR GLVENDFLTK
VLNGMAFAGF VSERGPPYRA CDLFDELVAF EVERIKVEEK NPLKMIKHIR ELAEQLFKNE
NPNPHMAFQK VPRPTEGSHL RVHILPFPKI NEARVQELIQ ENLAKNQNAP PATRIEKKCV
VPAGPPVVSI MEKVITVFNS AQRLEVVRNC ISFIFENKTL ETEKTLPAAL RALKGKAARQ
CLTDELGLHV QQNRAILDHQ QFDYIIRMMN CTLQDCSSLE EYNIAAALLP LTSAFYRKLA
PGVSQFAYTC VQDHPIWTNQ QFWETTFYNA VQEQVRSLYL SAKDDNHIPH LKQKLPDGQH
QEKTAMDLAA EQLRLWPTLS KSTQQELVQH EESTVFSQAI HFANLMVNLL VPLDTSKNKL
LRASAPGDWE SGSNSIVTNS IAGSVAESYD TESGFEDSEN SDVANSVVRF IARFIDKVCT
ESGVTQDHIR SLHCMIPGIV AMHIETLEAV HRESRRLPPI QKPKILRPAL LPGEEIVCEG
LRVLLDPDGR EEATGGLLGG PQLLPAEGAL FLTTYRILFR GTPHDQLVGE QTVVRSFPIA
SITKEKKITM QNQLQQSVQE GLQITSASFQ LIKVAFDEEV SPEVVDIFKK QLMKFRYPQS
IFSTFAFAAG QTTPQIILPK QKEKNTSFRT FSKTIVKGAK KAGKMTIGRQ YLLKKRTGTI
VEERVNRPGW NEEDDISVSD DSELPTSTTL KASEKSTMEQ LVEKACFRDY QRLGLGTISG
NSSRSKPEYF RVTASNRLYS LCRSYPGLLV IPQAVQDSSL PRVARCYRHN RLPVVCWKNS
RSGTLLLRSG GFHGKGVVGL FKSQNSPQAV STSSLESSSS IEQEKYLQAL LTAVIVHQKL
RGSSTLTVRP ALALSPVHGY RDKSFTQSNP KSSAKEPVHN QGVWASLRSS TRLISSPTSF
IDVGARLAGK DHSASFSNST YLQNQLLKRQ AALYIFGEKS QLRSSKVEFA FNCEFVPVEF
HEIRQVKASF KKLMRACIPS TIPTDSEVTF LKALGDSEWF PQLHRIMQLA VVVSEVLENG
SSVWVCLEEG WDITTQVTSL AQLLSDPFYR TIAGFRTLVE KEWLSFGHKF SQRSSLALNS
QGGGFAPIFL QFLDCVHQVH NQYPTEFEFN LYYLKFLAFH YVSNRFKTFL LDSDYERLEH
GTLFDDKGDK HAKKGVCIWE CIDKMHTRSP IFFNYLYSPV EVEALKPNVN VSSLKKWDYY
TEETLSAGPS YDWMMLTPKH FPYEESDVAG GAGPQSQRKT VWPCYDDVTC SQPDALTRLF
SEIEKLEHKL NQTPERWHQL WEKVTTDLKE EPRTAHSLRH SAGSPGIAST NVPSYQKRPA
LHPLHRGLGE DQSTTTAPSN GVEHRAATLY SQYTSKNDEN RSFEGTLYKR GALLKGWKPR
WFVLDVTKHQ LRYYDSGEDT SCKGHIDLAE VEMVIPAGPS MGAPKYTSDK AFFDLKTSKR
VYNFCAQDGQ SAQQWMDRIQ SCISDA
//
