ID E9Q1F5_MOUSE Unreviewed; 1742 AA.
AC E9Q1F5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Myosin VC {ECO:0000313|Ensembl:ENSMUSP00000042229.7};
GN Name=Myo5c {ECO:0000313|Ensembl:ENSMUSP00000042229.7,
GN ECO:0000313|MGI:MGI:2442485};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000042229.7, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000042229.7, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000042229.7,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000042229.7}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000042229.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; NP_001074791.1; NM_001081322.1.
DR AlphaFoldDB; E9Q1F5; -.
DR SMR; E9Q1F5; -.
DR STRING; 10090.ENSMUSP00000042229; -.
DR iPTMnet; E9Q1F5; -.
DR PhosphoSitePlus; E9Q1F5; -.
DR jPOST; E9Q1F5; -.
DR MaxQB; E9Q1F5; -.
DR PaxDb; 10090-ENSMUSP00000042229; -.
DR PeptideAtlas; E9Q1F5; -.
DR ProteomicsDB; 349036; -.
DR Antibodypedia; 24945; 79 antibodies from 16 providers.
DR Ensembl; ENSMUST00000036555.8; ENSMUSP00000042229.7; ENSMUSG00000033590.9.
DR GeneID; 208943; -.
DR KEGG; mmu:208943; -.
DR UCSC; uc009qru.1; mouse.
DR AGR; MGI:2442485; -.
DR CTD; 55930; -.
DR MGI; MGI:2442485; Myo5c.
DR VEuPathDB; HostDB:ENSMUSG00000033590; -.
DR eggNOG; KOG0160; Eukaryota.
DR GeneTree; ENSGT00940000157971; -.
DR HOGENOM; CLU_000192_9_1_1; -.
DR InParanoid; E9Q1F5; -.
DR OMA; EIMFDDR; -.
DR OrthoDB; 1094820at2759; -.
DR PhylomeDB; E9Q1F5; -.
DR TreeFam; TF328771; -.
DR BioGRID-ORCS; 208943; 2 hits in 78 CRISPR screens.
DR ChiTaRS; Myo5c; mouse.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; E9Q1F5; Protein.
DR Bgee; ENSMUSG00000033590; Expressed in left lung lobe and 117 other cell types or tissues.
DR ExpressionAtlas; E9Q1F5; baseline and differential.
DR Genevisible; E9Q1F5; MM.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0032254; P:establishment of secretory granule localization; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd15476; Myo5c_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037991; Myo5c_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 5.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|MaxQB:E9Q1F5,
KW ECO:0007829|PeptideAtlas:E9Q1F5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 8..62
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 67..753
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1421..1697
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 632..654
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 884..1098
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1211..1245
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1303..1344
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 161..168
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1742 AA; 202702 MW; 751DA32B1CE39498 CRC64;
MAVAELYAQY NRVWIPDPEE VWKSAEIAKD YRAGDRVLRL LLEDGMELEY PVDPGSLPPL
RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY SGIILVAMNP YKQLPIYGDA
IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR NNRNQSIIVS GESGAGKTVS ARYAMRYFAT
VSKSSSNAHV EDKVLASNPI TEAVGNAKTT RNDNSSRFGK YTEISFDERN QIIGANMRTY
LLEKSRVVFQ SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVNDR
ADMVETQKTF TLLGFKKDFQ MDVFKILAAI LHLGNVQVTT VGNERSSVSE DDSHLKVFCE
LLGLETSKVA QWLCNRKIVT SSETVVKPMT RPQAINARDA LAKKIYAHLF DFIVEQINQA
LHFSGKQHTF IGVLDIYGFE TFDVNSFEQF CINYANEKLQ QQFNLHVFKL EQEEYMKEDI
PWTLIDFYDN QPVIDLIEAK MGILELLDEE CLLPHGTDEN WLQKLYNNFV NKNSLFEKPR
MSNSSFIIQH FADKVEYQCE GFLEKNRDTV YDMLVEILRA SKFHLCAAFF QESPVPSSPF
GAMITVKSAK QVIKPNTKHF RTTVGNKFRS SLYLLMETLN ATTPHYVRCI KPNDEKMPFE
FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYLEFYSRYG ILMTQQELSL SDKKEVCKVV
LHRLIQDSNQ YQFGRTKIFF RAGQVAYLEK LRLDKLRQDC IMIQKHVRGW LQRRKFLRER
QAALTIQRYF RGQQTVRKAI TATALKEAWA AIILQKYCRG YLVRNLYQLI RVATITIQAH
TRGFLARRRY RKLLQEHKAV ILQKYARAWL ARRRFQNIRR FVLNIQLTYR VQRLQKKLED
QNRENHGLVE KLTSLAALRV GDLEKVQKLE AELEKAATHR HSYEEKGRRY RDTVEERLSK
LQKHNAELEL QRERAEQMLQ EKSEELKEKM DKLTRQLFDD VQKEEQQRLV LEKGFELKTQ
AYEKQIESLR EEIKALKDER SQLHHQLEEG QVTSDRLKGE VARLSKQAKT ISEFEKEIEL
LQAQKIDVEK HVQSQKREMR ERMSEVTKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA
YEGLKKATRV LESHFQSQKD CYEKEIEGLN FKVVHLSQEI NHLQKLFREE TDINESIRHE
VTRLTSENMM IPDFKQQISE LERQKQDLES RLKEQAEKIE GKLEEPFSHL NRIREEERMQ
GRAVEAQSEM HPEGKERLVG AIHEPHEAIK FPKKQPEAEE EVESILQQEA SRLSLEKRDL
EEELDMKDRM IRRLQDQVKT LTKTTEKANH VHLPSGSREY LGMLEYKKED EGKLIQNLIL
DLKPRGVVVN MIPGLPAHIL FMCVRYADSL NDANMLKSLM NSAINGIKHV VKEHFEDLEM
LSFWLSNTCH FLNCLKQYSG EEEFMKYNSP QQNKNCLNNF DLTEYRQILS DVAIRIYHQF
IIVMENNLQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDAYTMTS ILQQLSYFYS
TMCQNGLDPE IVRQAVKQLF YLVGAVTLNS LLLRKDMCSC RKGMQIRCNI SFLEEWLKDK
NVQSSLAKET LEPLSQAAWL LQVKKTTDSD AKEIAQCCTS LSAVQIIKIL NSYTPIDDFE
KRVNPSFVRK VQALLNNRGD SAQLMLDTKY LFQVTFPFTA SPHALEMTQI PSSFKLGFLR
RL
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