ID E9Q1M1_MOUSE Unreviewed; 2796 AA.
AC E9Q1M1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=PDZ domain containing 2 {ECO:0000313|Ensembl:ENSMUSP00000074788.6};
GN Name=Pdzd2 {ECO:0000313|Ensembl:ENSMUSP00000074788.6,
GN ECO:0000313|MGI:MGI:1922394};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000074788.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000074788.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074788.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000074788.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074788.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001074533.1; NM_001081064.1.
DR RefSeq; XP_006520222.1; XM_006520159.3.
DR RefSeq; XP_006520223.1; XM_006520160.3.
DR RefSeq; XP_006520224.1; XM_006520161.3.
DR RefSeq; XP_006520225.1; XM_006520162.2.
DR RefSeq; XP_006520226.1; XM_006520163.3.
DR RefSeq; XP_006520227.1; XM_006520164.2.
DR SMR; E9Q1M1; -.
DR STRING; 10090.ENSMUSP00000074788; -.
DR GlyGen; E9Q1M1; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; E9Q1M1; -.
DR PhosphoSitePlus; E9Q1M1; -.
DR jPOST; E9Q1M1; -.
DR MaxQB; E9Q1M1; -.
DR PaxDb; 10090-ENSMUSP00000074788; -.
DR PeptideAtlas; E9Q1M1; -.
DR ProteomicsDB; 314273; -.
DR Antibodypedia; 22684; 184 antibodies from 31 providers.
DR DNASU; 68070; -.
DR Ensembl; ENSMUST00000075317.12; ENSMUSP00000074788.6; ENSMUSG00000022197.17.
DR GeneID; 68070; -.
DR KEGG; mmu:68070; -.
DR UCSC; uc007vhq.1; mouse.
DR AGR; MGI:1922394; -.
DR CTD; 23037; -.
DR MGI; MGI:1922394; Pdzd2.
DR VEuPathDB; HostDB:ENSMUSG00000022197; -.
DR eggNOG; KOG0708; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000157749; -.
DR HOGENOM; CLU_000714_0_0_1; -.
DR InParanoid; E9Q1M1; -.
DR OMA; QEGTMSR; -.
DR OrthoDB; 2915005at2759; -.
DR TreeFam; TF326303; -.
DR BioGRID-ORCS; 68070; 3 hits in 78 CRISPR screens.
DR ChiTaRS; Pdzd2; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; E9Q1M1; Protein.
DR Bgee; ENSMUSG00000022197; Expressed in olfactory tubercle and 214 other cell types or tissues.
DR ExpressionAtlas; E9Q1M1; baseline and differential.
DR Genevisible; E9Q1M1; MM.
DR GO; GO:0045177; C:apical part of cell; ISO:MGI.
DR GO; GO:0005911; C:cell-cell junction; ISO:MGI.
DR GO; GO:0034451; C:centriolar satellite; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR CDD; cd00992; PDZ_signaling; 5.
DR Gene3D; 2.30.42.10; -; 6.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR11324; IL16-RELATED; 1.
DR PANTHER; PTHR11324:SF16; PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 5.
DR SMART; SM00228; PDZ; 6.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR PROSITE; PS50106; PDZ; 6.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:E9Q1M1,
KW ECO:0007829|PeptideAtlas:E9Q1M1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 94..160
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 334..419
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 588..674
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 731..801
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 2580..2652
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 2708..2793
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 188..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1654..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1760..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2017..2221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2295..2426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2461..2484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2501..2521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2665..2697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1654..1671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1760..1790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1815..1829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1880..1894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1914..1942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2067..2146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2199..2221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2295..2380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2402..2426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2461..2476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2501..2515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2796 AA; 296726 MW; 6C572A52CC451A69 CRC64;
MPITQDNALL HLPLLYEWLQ NSLREGGDSP EQRLCQAAIQ KLQEYIQLNL AVEENTVPPE
HSPPEMEICT VYLTKQLGDT ETVGLSFGNI PVFGDYGEKR RGGKKRKTHQ GPVLDVGCIW
VTELRKNSPA GKSGKVRLRD EILSLNGQLM VGVDVSGASY LAEQCWNGGF IYLIMLRRFK
QKAHLTYNGN SGNSSEPGET PTLELGDQTS KKGKRTRKFG VISRPAIIKA PEDSKSNSGC
DTADDPSSEL ENGTDSELGN GHAFELENGP NSLKDVAGPH LERSEADREA ELRVPKTEAP
LSDSNDKRRF SKTGKTNFQS SDSLAREEVG RIWKMELLKE SDGLGIQVSG GRGSKRSPHA
IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA VAILRSATGM VQLVVASKES
SAEDLLKLTS KSLPDLTSSV EDISSWTDNE DQEAARDDEE GTGSAAVRGT MLGSEESQDV
GSSEESKGNN LESPKQGNSK MKLKSRLSGG VHRLESVEEY NELMVRNGDP RIRMLEVSRD
GRKHSLPQLL DSTGTSQEYH IVKKSTRSLS TTHVESPWRL IRPSVISIIG LYKEKGKGLG
FSIAGGRDCV RGQMGIFVKT IFPNGSAAED GRLKEGDEIL DVNGIPIKGL TFQEAIHTFK
QIRSGLFVLT VRTKLLSPSL TPCSTPTHMS RSSSPSFNSS GGAPAGGGQD EGGSASLGRK
APGPKDRIVM EVTLNKEPRV GLGIGACCLA LENSPPGIYI HSLAPGSVAK MESNLSRGDQ
ILEVNSVNVR HAALSKVHAI LSKCPPGPVR LVIGRHPNPK VSEQEMDEVI ARSTYQESKE
ANSSPSLGTP LKSPSLAKKD SLLSESELSQ YFVHDGQGSL SDFVVAGSED EDHPGSGYET
SEDGSLLTVP SAYRETGKAR ANSLVTLGSQ RGSGLLHKQV TVARQASLPG SPQVLRNPLL
RQRRVRCYDS NDGSDDEDFD GEGDCVSLPG VLPGPGRPLV QDDTRFALAT SSKSIDVNKQ
DERLQKPLVS KACSVPLLGS SLDSEHSIHG GTAGTPPKAA SLPGSVETPK NGPGGSRRKE
MSGSRSSPKL EYRVPADTQS PRSPENGTSP PQKTENLVSR HKPVARISPH YKRSDAEEAP
SETANGPCAQ DLKVQASSVK DPVAGHQPGG TAEKELRGNP TPGDSSVPTN CGPASTPCHP
NTGLPTENPQ GAAPECGPHP GTGWDGSSDH PPSPGKSREV RPDSSETPAV TEQVLQPESL
SQPVSPGTSE PESQGVSKMK PASQRSLSPR EKASALPDSS RTWAGPGDST PSTRRAAVPM
SIGETRATAI PHPSLLGQER SRDPSGPSKA LETPGHCVPT SLKDRALLEE TASASGKLSH
AGPSVPVTTD GTLSGSTESP VTDIDKFIGE APEAWLSQSP QRADCRTHQD IFESQPPGGA
GGGSSHHGKT GGTGSPPPPQ WTFQPSVLDS VHPDKQLAGN KNFLNNYSRN FSSFHEDGVS
EPSPSSMYGD AEDSSSDPES LVEDPRAAAR NNWPAPPSHE SSRKEGSSES EDEQIEICAP
GGCPETPVPA QAPAQAAGGA VPSVQQTVRE PVGDACEKAC FMTGASNTCI PGSSQPFSFL
DVSSLEHETW AGVQTSRSHM PGCAEETLAV SSTGSVVGDS QPSQTTRPCG NPPFVLRNPD
MVNGLGQDLL DEGTPDKGAD ASHVMSSVYA LGAEGPKNGE AVLANLHIAK GGNLDGLLQK
PKTTSRRPIM TWFKDINKDS QGAHLQSKSE KEQPSMLAMS PGSKGNTVNP SHRKGMAVPK
SPPPRQKSQE NKDLSPKSPV ETLSNCQKPK GSPKLKRLNS KSKASPEAPV ASPAKGGRTD
HRKSLPSPQA AHKMLSKAVS HRLHIADQEE PKNTAGDTSK PPQCVPESKP PLAASGSLRT
SASDTSIRTI TSPLTSPKPL PEQGANNRFH MAVYLESDTS CPATSRPPRY GPEGKVPHAN
SGSVSPSASR TNIALAGVRQ SKQFTHSRVD LVLTEAAQPQ GISEKGTEKM ASDPLERTNQ
LKIIEISSER MPKNACGDKP PGSDRKGGFL TQSNCQEKSS VRLRQSAESS PKQPHFPPSQ
ASQGEQEMRW SYSMARLASS SPSAPQLPSK MPDYSQGKSS QMPASVGVPK NGVPVGLAGE
EPPYFTPRPA TRTYSMPAQF SSHFGREGLS PPSPSHSPQD PQVTAMSGSL SEKSAKGVTN
EQGVYSVKPL LETLRNPPPV DVGDVSAVPE ASGLIPDKLK VTRRHYYCEQ SWPHESTSFF
SVKQRIKSFE NLANSDRPAA KSATSPFLSV SSKPPVNRRS SGSITSGRPS DGTARSLRRS
LSSCSENQSE ASSLLPQMTK SPSSVTLTVS RQNPPETNNK GHSPDPKKSL VPVGIPISTG
SPASPIKRNK SSVRHAQPSP VSRSKLQELR ALSMPDLDKL CSGEDYSASP GAVLFRTQLE
ITPRRSQGSP ATSPASSPAR GHADVNGSAF LSCPVNGGNR VYPKGNSSPT VPTGSREWGE
SLRAMPSGKS WSVNLDQLLA SVGYQQRLQA VLSLVGSKSP ILPLIQEAKA QSENKEDICF
IVLNKKEGSG LGFSVAGGAD VEPESVLVHR VFSQGVASQE GTVSQGDFLL SVNGTSLAGL
SHSEVTKVLH QAELHKHVLM IIKKGNDQPR PSFRQEPPSA NGKAPFPRRT LPLEPGAGRN
GAAHDALCVE VLKTSAGLGL SLDGGKSSIA GDGPLVIKRV YQGGAAEQAG TIEAGDEILA
INGKPLVGLV HFDAWNIMKS VPEGPVQLVI RKHRDS
//
