ID E9Q2A2_MOUSE Unreviewed; 434 AA.
AC E9Q2A2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Ammonium transporter Rh type B {ECO:0000256|ARBA:ARBA00041038};
DE AltName: Full=Rhesus blood group family type B glycoprotein {ECO:0000256|ARBA:ARBA00043022};
DE Flags: Fragment;
GN Name=Gm38392 {ECO:0000313|Ensembl:ENSMUSP00000132187.3,
GN ECO:0000313|MGI:MGI:5613632};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000132187.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000132187.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000132187.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000132187.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000132187.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526;
CC Evidence={ECO:0000256|ARBA:ARBA00036376};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74892;
CC Evidence={ECO:0000256|ARBA:ARBA00036376};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747,
CC ChEBI:CHEBI:28938; Evidence={ECO:0000256|ARBA:ARBA00036550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28748;
CC Evidence={ECO:0000256|ARBA:ARBA00036550};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28749;
CC Evidence={ECO:0000256|ARBA:ARBA00036550};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391,
CC ChEBI:CHEBI:59338; Evidence={ECO:0000256|ARBA:ARBA00036492};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74392;
CC Evidence={ECO:0000256|ARBA:ARBA00036492};
CC -!- SUBUNIT: Interacts (via C-terminus) with ANK2 and ANK3; required for
CC targeting to the basolateral membrane. {ECO:0000256|ARBA:ARBA00038590}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000256|ARBA:ARBA00011036}.
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DR jPOST; E9Q2A2; -.
DR Ensembl; ENSMUST00000165196.8; ENSMUSP00000132187.3; ENSMUSG00000103766.6.
DR AGR; MGI:5613632; -.
DR MGI; MGI:5613632; Gm38392.
DR VEuPathDB; HostDB:ENSMUSG00000103766; -.
DR HOGENOM; CLU_021386_0_0_1; -.
DR OMA; ATHNAYG; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; E9Q2A2; Protein.
DR Bgee; ENSMUSG00000103766; Expressed in right kidney and 36 other cell types or tissues.
DR ExpressionAtlas; E9Q2A2; baseline and differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:InterPro.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR InterPro; IPR031679; SSTK-IP.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF42; AMMONIUM TRANSPORTER RH TYPE B; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR Pfam; PF15836; SSTK-IP; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..392
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
FT REGION 413..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000132187.3"
SQ SEQUENCE 434 AA; 46531 MW; B8BAC7054290B674 CRC64;
XEDSVACFCP AKSSPSYIDL PANFTPANFL TIQTKLSSGF QDVHVMVFVG FGFLMVFLQR
YGFSSVGFTF LVASLTLQWA TLLQGFLHSF HGGHIHVGVE SLINADFCAG AVLISFGAVL
GKTGPAQLLL MALLEAVLFS VNEFILLSLL GVRDAGGSMT IHTFGAYFGL FLSWVLYRSQ
LEKSRHRQSS VYNSDLFAMI GTIFLWVFWP SFNSAPTALG DGQHRTVVNT YYSLTASTLS
TFALSALVSG DGRLDMVHVQ NAALAGGVVV GTSSEMMLTP FGALAAGFLA GTVSTLGYKF
FTPILESRFK LQDTCGVHNL HGMPGVLGAI LGVVVAALAT HEAYGDGLQS VFPLIAKGQR
SATSQAVYQL FGMFVTLVFA SVGGSLGGLL LRLPFLDSPP DSQCFEDQVY WEVPGEQETE
TQRPLRGGES DTRA
//
