ID E9Q2B2_MOUSE Unreviewed; 2386 AA.
AC E9Q2B2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Nuclear receptor corepressor 1 {ECO:0000256|ARBA:ARBA00044171};
GN Name=Ncor1 {ECO:0000313|Ensembl:ENSMUSP00000098628.4,
GN ECO:0000313|MGI:MGI:1349717};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000098628.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [3] {ECO:0007829|PubMed:19131326}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000098628.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000098628.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [7] {ECO:0000313|Ensembl:ENSMUSP00000098628.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000098628.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR SMR; E9Q2B2; -.
DR IntAct; E9Q2B2; 1.
DR MINT; E9Q2B2; -.
DR EPD; E9Q2B2; -.
DR jPOST; E9Q2B2; -.
DR MaxQB; E9Q2B2; -.
DR PeptideAtlas; E9Q2B2; -.
DR ProteomicsDB; 363391; -.
DR Antibodypedia; 13188; 480 antibodies from 37 providers.
DR Ensembl; ENSMUST00000101067.10; ENSMUSP00000098628.4; ENSMUSG00000018501.18.
DR AGR; MGI:1349717; -.
DR MGI; MGI:1349717; Ncor1.
DR VEuPathDB; HostDB:ENSMUSG00000018501; -.
DR GeneTree; ENSGT00940000155093; -.
DR HOGENOM; CLU_000922_0_0_1; -.
DR ChiTaRS; Ncor1; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000018501; Expressed in embryonic post-anal tail and 265 other cell types or tissues.
DR ExpressionAtlas; E9Q2B2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Proteomics identification {ECO:0007829|EPD:E9Q2B2,
KW ECO:0007829|MaxQB:E9Q2B2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 436..487
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 620..674
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 620..670
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 623..674
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1631..1714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1836..1874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1893..1993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2019..2107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2236..2329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2359..2386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..620
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1903..1917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2019..2061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2072..2089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2277..2307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2386 AA; 264038 MW; 75AF465BC378468B CRC64;
MSSSGYPPNQ GAFSTEQSRY PSHSVQYTFP STRHQQEFAV PDYRSSHIEV SQASQLLQQQ
QQQQQLRRRP SLLSEFHPGS DRPQERRTGY EQFHSGPSPV DHDSLESKRP RLEPVSDAHF
QRVSAAVLPL VHSLPEGLRS SADAKKDSAF GSKHEAPSSP LAGQPCGDDQ NASPSKLSKE
ELIQSMDRVD REIAKVEQQI LKLKKKQQQL EEEAAKPPEP EKPVSPPPVE QKHRSIVQII
YDENRKKAEE AHKIFEGLGP KVELPLYNQP SDTKVYHENI KTNQVMRKKL ILFFKRRNHA
RKQREQKICQ RYDQLMEAWE KKVDRIENNP RRKAKESKTR EYYEKQFPEI RKQREQQERF
QRVGQRGAGL SATIARSEHE ISEIIDGLSE QENNEKQMRQ LSVIPPMMFD AEQRRVKFIN
MNGLMEDPMK VYKDRQFMNV WTDHEKEIFK DKFIQHPKNF GLIASYLERK SVPDCVLYYY
LTKKNENYKA LVRRNYGKRR GRNQQIARPS QEEKVEEKEE DKAEKTEKKE EEKKDDEEKD
DKEDSKETTK EKDRTEATAE EPEEREQVTP RGRKTANSQG RRKGRVTRSM TSEAAAANAA
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA
QCKNFYFNYK RRHNLDNLLQ QHKQKVSRAV VASRKPREER DVSQCESVAS TVSAQEDEDI
EASNEEENPE DSEAVPTTKP AERESVEAQV TDSASAETAE PMDVDHEECG AEGSSVLDPP
APTKADSVDP EMQVPENTAS KGEGDAKERD LESTSEKTEA RDEDVVVAEQ IERPEPQSDD
DSSATCSADE GVDGEPERQR VFPMDAKPSL LTPPGSILIS SPIKPNPLDL PQLQHRAAVI
PPMVSCTPCN IPIGTPVSGY ALYQRHIKAM HESALLEEQR QRQEQVDLEC RSSTSPCSTS
KSPNREWEVL QPAPHQVITN LPEGVRLPTT RPTRPPPPLI PSSKTTVASE KPSFIMGGSI
SQGTPGTYLS SHNQAYPQEA PKPSVGSISL GLPRQQESTK AAPLTYIKQE EFSPRSQNSQ
PEGLLVRAQH EGTAGAVQEG SITRGTPASK ISVETISSLR GSITQGTPAL PQAGIPTEAL
VKGPVSRMPI EESSPEKVRE EAASKGHVIY EGKSGHILSY DNIKNAREGT RSPRTAHEMS
LKRSYEAVEG SIKQGLICRA LPRGSPHSDL KERTVLSGSI MQGTPRATAE SFEDGLKYPK
QIKRESPPIR AFEGAITKGK PYDGITTIKE MGRSIHEIPR QDILTQESRK TPEVVQSTRP
IIEGSISQGT PIKFDNNSGQ SAIKHNVKSL ITGPSKLPRG MLEIVPENIK VVERGKYEDV
KAGEPVRARH TSVVSSGPSV LRSTLHEAPK AQLSPGLYDD SSARRTPVSY QNTISRGSPM
MNRTSDVSSS KSASHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH HRSSAAGEVY
RSHLPTHLDP AMPFHRALDP AAAAYLLQRQ LSPTPGYPSQ YQLYAMENTR QTILNDYITS
QQMQVNLRPD VTRGLSPREQ PLGLPYPATR GIIDLTNMPP TILVPHAGGT STPPMDRITY
IPGTQVTFPP RPYNAASLSP GHPTHLAAAA SAERERERER EKERERERER ERERERERIA
AAPADLYLRP GSEQPGRPGS HGYVRSPSPS VRTQETILQQ RPSVFQGTNG TSVITPLDPT
AQLRIMPLPS GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE
ENLRSRSAAV SEQQQLEQKN LEVEKRSVQC VCTSSALPSG KAQPHASVVY SEAGKDKGPP
PKSRYEEELR TRGKTTITAA NFIDVIITRQ IASDKDARER GSQSSDSSSS LSSHRYETAS
DAIEVISPAS SPAPPQEKPQ AYQPDMVKAN QAENESTRQY EGPLHHYRSQ QESPSPQQQP
PLPPSSQSEG MGQVPRTHRL ITLADHICQI ITQDFARNQV PSQPSTSTFQ TSPSALSSTP
VRTKTSSRYS PESQSQTVLH PRPGPRVSPE NLVDKSRGRP GKSPERSHIP SEPYEPISPP
QGPAVHEKQD SMLLLSQRGV DPAEQRSDSR SPGSISYLPS FFTKLESTSP MVKSKKQEIF
RKLNSSGGGD SDMAAAQPGT EIFNLPAVTT SGAVSSRSHS FADPASNLGL EDIIRKALMG
SFDDKVEDHG VVMSHPVGIM PGSASTSVVT SSEARRDEGE PSPHAGVCKP KLINKSNSRK
SKSPIPGQSY LGTERPSSVS SVHSEGDYHR QTPGWAWEDR PSSTGSTQFP YNPLTIRMLS
STPPTQIACA PSAITQAAPH QQNRIWEREP APLLSAQYET LSDSDD
//
