GenomeNet

Database: UniProt
Entry: E9Q3P4_MOUSE
LinkDB: E9Q3P4_MOUSE
Original site: E9Q3P4_MOUSE 
ID   E9Q3P4_MOUSE            Unreviewed;      2997 AA.
AC   E9Q3P4;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   10-FEB-2021, entry version 72.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSMUSP00000129738};
GN   Name=Cenpf {ECO:0000313|Ensembl:ENSMUSP00000129738,
GN   ECO:0000313|MGI:MGI:1313302};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000129738, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000129738, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129738,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000129738}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129738};
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC140679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001074832.2; NM_001081363.2.
DR   SMR; E9Q3P4; -.
DR   IntAct; E9Q3P4; 12.
DR   STRING; 10090.ENSMUSP00000129738; -.
DR   EPD; E9Q3P4; -.
DR   jPOST; E9Q3P4; -.
DR   MaxQB; E9Q3P4; -.
DR   PaxDb; E9Q3P4; -.
DR   PeptideAtlas; E9Q3P4; -.
DR   PRIDE; E9Q3P4; -.
DR   Antibodypedia; 4038; 260 antibodies.
DR   Ensembl; ENSMUST00000171929; ENSMUSP00000129738; ENSMUSG00000026605.
DR   GeneID; 108000; -.
DR   KEGG; mmu:108000; -.
DR   UCSC; uc007eao.2; mouse.
DR   CTD; 1063; -.
DR   MGI; MGI:1313302; Cenpf.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; E9Q3P4; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Reactome; R-MMU-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-MMU-2467813; Separation of Sister Chromatids.
DR   Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-MMU-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-MMU-68877; Mitotic Prometaphase.
DR   Reactome; R-MMU-9648025; EML4 and NUDC in mitotic spindle formation.
DR   BioGRID-ORCS; 108000; 1 hit in 17 CRISPR screens.
DR   ChiTaRS; Cenpf; mouse.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; E9Q3P4; protein.
DR   Bgee; ENSMUSG00000026605; Expressed in primary oocyte and 221 other tissues.
DR   Genevisible; E9Q3P4; MM.
DR   GO; GO:0005930; C:axoneme; IDA:MGI.
DR   GO; GO:0005813; C:centrosome; IDA:MGI.
DR   GO; GO:0000775; C:chromosome, centromeric region; ISO:MGI.
DR   GO; GO:0036064; C:ciliary basal body; IDA:MGI.
DR   GO; GO:0097539; C:ciliary transition fiber; IDA:MGI.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0030496; C:midbody; ISO:MGI.
DR   GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR   GO; GO:0016363; C:nuclear matrix; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0045120; C:pronucleus; IDA:MGI.
DR   GO; GO:0005819; C:spindle; ISO:MGI.
DR   GO; GO:0000922; C:spindle pole; ISO:MGI.
DR   GO; GO:0070840; F:dynein complex binding; ISO:MGI.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR   GO; GO:0008134; F:transcription factor binding; ISO:MGI.
DR   GO; GO:0007059; P:chromosome segregation; ISO:MGI.
DR   GO; GO:0001822; P:kidney development; ISO:MGI.
DR   GO; GO:0051310; P:metaphase plate congression; ISO:MGI.
DR   GO; GO:0000278; P:mitotic cell cycle; ISO:MGI.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR   GO; GO:0015031; P:protein transport; ISO:MGI.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; ISO:MGI.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IDA:MGI.
DR   GO; GO:0021591; P:ventricular system development; ISO:MGI.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0000213|EPD:E9Q3P4,
KW   ECO:0000213|MaxQB:E9Q3P4, ECO:0000213|PeptideAtlas:E9Q3P4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          1..300
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1894..2035
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2131..2270
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2313..2449
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2852..2896
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          206..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          763..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1522..1548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1711..1737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2774..2997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          159..186
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          273..335
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          343..395
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          516..612
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          623..643
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          657..677
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          710..737
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          831..879
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          905..939
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          968..1005
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1010..1090
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1095..1115
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1131..1165
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1208..1256
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1269..1289
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1311..1331
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1550..1613
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1625..1645
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1790..1810
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1825..1852
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1883..1910
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1946..1997
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2023..2078
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2107..2127
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2142..2197
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2205..2285
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2324..2351
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2356..2457
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2465..2492
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2500..2534
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2559..2600
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2615..2709
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2719..2746
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2754..2774
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        206..226
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..490
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2775..2816
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2837..2867
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2882..2964
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2997 AA;  342472 MW;  3AEE30F1D554DEC5 CRC64;
     MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK QKQKVEDGKT
     EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ ESQLSSCKKQ IEKLEQELKR
     CKSEFERSQQ VAQSADVSLN PCSTPQKLFA TPLTPSSTYE DLKEKYNKEV EERKRLEEEV
     KALHAKKVSL PVSQATMNHR DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH
     FLGEEVSPNK SSMKTGRGDC SSLPGEPHSA QLLHQAKAQN QDLKSKMTEL ELRLQGQEKE
     MRSQVNKCQD LQLQLEKTKV ELIEKERILN KTRDEVVRST AQYDQAAAKC TTLEQKLKTL
     TEELSCHRQN AESAKRSLEQ RIKEKEKELQ EELSRQHQSF QALDSEYTQM KTRLTQELQQ
     VKHLHSTLQL ELEKVTSVKQ QLERNLEEIR LKLSRAEQAL QASQVAENEL RRSSEEMKKE
     NSLIRSQSEQ RTREVCHLEE ELGKVKVSLS KSQNFAEEMK AKNTSQEIML RDLQEKLNQQ
     ENSLTLEKLK LALADLERQR NCSQDLLKKR EHHIDQLNNK LNKIEKEFET LLSALELKKK
     ECEELKEEKN QISFWKIDSE KLINQIESEK EILLGKINHL ETSLKTQQVS PDSNERIRTL
     EMERENFTVE IKNLQSMLDS KMVEIKTQKQ AYLELQQKSE SSDQKHQKEI ENMCLKANKL
     TGQVESLECK LQLLSSEVVT KDQQYQDLRM EYETLRDLLK SRGSSLVTNE DNQRSSEDNQ
     RSSEDNQRGS LAFEQQPAVS DSFANVMGRK GSINSERSDC SVDGGRSPEH IAILQNRVTS
     LESSLESQNQ MNSDLQMRCE ELLQIKGEVE ENLSKAEQIH QNFVAETNQC ISKLQEDAAV
     HQNIVAETLA TLESKEKELQ LLKEKLEAQQ TEVQKLNKNN CLLEGTLKEL QLLSDTLSSE
     KKEMNSIISL SKKNIEELTQ ANEALKEVNE ALEQEKMNLL QKHEKITSCI AEQERSIAEL
     SDQYKQERLQ LLQRCEETEA VLEDLRGNYK TAQENNAKLE CMLSECTALC ENRKNELEQL
     KETFAKEQQE FLTKLAFAEE QNRKLMLELE IEQQTVRSEI TNTNKHSMSA TDGLRQECLT
     LNEEQNEQQN EVSNLTHENE QLMELTQTKH DSYLAVEPVE NSVKATEDEI GKSSSQYQMD
     IDTKDISLDS YKAQLVHLEA LVRILEVQLD QSEEENKKLH LELQTIREEL ETKSSQDPQS
     QARTGLKDCD TAEEKYVSML QELSASQNEN AHLQCSLQTA VNKLNELGKM CDVLRVEKLQ
     LESELNDSRT ECITATSQMT AEVEKLVSEM KMLNHESALS QNELMKDTSG GEFHDKANHS
     SVFLTPLDSS NFCEQMTLSS KEVRVHFAEL QEKFSCLQSE HKILHDQHCE VSSKMSALRS
     YVDTLKAENS ALSMSLRTLQ GDLVKEGEPA AEGGHGLPLS FCGADSPSLT NFGETSFYKD
     VLEQTGDTCH LSLEGNASAN SCDLDEEFSS SLEEETLTEK ESPPAPGRTV EGLEVLCQVY
     LQSLKNLEEK TESQRIMKNK EIEKLEQLLS SERKELSCLR KQYLSEKEQW QQKLTSVTLE
     MESKLAEEKQ QTKTLSLELE VARLQLQELD LSSRSLLGTD LESVVRCQND NYDIKESEVY
     ISETTEKTPK QDTDQTCDKD IQQDLGLETS VTESETTRLT GEGCEEQPPK TNCEAPAEDK
     TQDCSECISE LCSSSNVLVP MDVLEDQGSI QNLQLQKDTL NENLRLLPEV EDWDKKVESL
     LNEIMEADSK LSLQEVQLKM KIATCIQLEK IVKDLRKEKA DLSEKLESLP CNQEVCLRVE
     RSEEDLGFNL DMGANELLSK STKDNATNTE DNYKEKFLDM ERELTRIKSE KANIEHHILS
     VETNLEVVQA EKLCLERDTE SKQKVIIDLK EELFTVISER NRLREELDNV SKESKALDQM
     SKKMKEKIEE LESHQRESLR HIGAVESEVK DKADLIQTLS FNVGELTKDK AHLQEQLQNL
     QNDSQELSLA IGELEIQIGQ LNKEKESLVK ESQNFQIKLT ESECEKQTIS KALEVALKEK
     GEFAVQLSSA QEEVHQLRRG IEKLSVRIEA DEKKHLSAVA KLKESQRESD SLKDTVETLE
     RELERSEENQ ELAILDSENL KAEVETLKAQ KDEMTKSLRI FELDLVTVRT ERENLAKQLQ
     EKQSRVSELD ERCSSLRRLL EEKEQARVQM EEDSKSAMLM LQMQLKELRE EVAALCNDQE
     TLKAQEQSLD QPGEEVHHLK SSIRKLKVHI DADEKKHQNI LEQLKESKHH ADLLKDRVEN
     LEQELILSEK NMIFQAEKSK AEIQTLKSEI QRMAQNLQDL QLELISTRSE NENLMKELKK
     EQERVSDLET INSSIENLLK DKEQEKVQMK EEAKITVEML QTQLKELNET VVSLCNDQEV
     SKTKEQNLGS QVQTLELEKA QLLQDLGEAK NKYIIFQSSV NALTQEVEAG KQKLEKGEKE
     IRTLKEQLKS QEQLVCKLAQ VEGEQQLWQK QKLELRNVTM ALEQKVQVLQ SENNTLQSTY
     EALQNSHKSL ESELGLIKLE KVALVERVST ISGKEAELQR ELRDMLQKTT QLSEDYNKEK
     NRLTEEVEVL REELQNTKAA HLKSVNQLEK ELQRAQGKIK LMLKSCRQLE GEKEMLQKEL
     SQLEAAQQQR AGSLVDSNVD EVMTENKALK ETLEEKVKEA DKYLDKYCSL LISHEELEKA
     KEILEIEVAR LKSRQSRQDL QSSPLLNSSI PGPSPNTSVS EMKSASGQNK ASGKRQRSSG
     IWEHGKRAAP STAETFSKKS RKSDSKSTRP AEHEQETEFE PEGLPEVVKK GFADIPTGKT
     SPYILRRTTM ATRTSPRFAT QKLVGSSPSL GKENVVESSK PTAGGSRSQK VKVVQESSAD
     SHTAFQELPA KSLTASNIPG RNSTESPREG LRAKRAYPAS SPAAGPDPTN NENCRVQ
//
DBGET integrated database retrieval system