ID E9Q446_MOUSE Unreviewed; 455 AA.
AC E9Q446;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Ring finger protein 25 {ECO:0000313|Ensembl:ENSMUSP00000109350.2};
GN Name=Rnf25 {ECO:0000313|Ensembl:ENSMUSP00000109350.2,
GN ECO:0000313|MGI:MGI:1890215};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000109350.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000109350.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109350.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000109350.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109350.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001292159.1; NM_001305230.1.
DR AlphaFoldDB; E9Q446; -.
DR SMR; E9Q446; -.
DR MaxQB; E9Q446; -.
DR PeptideAtlas; E9Q446; -.
DR ProteomicsDB; 326964; -.
DR Antibodypedia; 34282; 176 antibodies from 28 providers.
DR DNASU; 57751; -.
DR Ensembl; ENSMUST00000113721.8; ENSMUSP00000109350.2; ENSMUSG00000026171.13.
DR GeneID; 57751; -.
DR UCSC; uc007bmt.3; mouse.
DR AGR; MGI:1890215; -.
DR CTD; 64320; -.
DR MGI; MGI:1890215; Rnf25.
DR VEuPathDB; HostDB:ENSMUSG00000026171; -.
DR GeneTree; ENSGT00390000001557; -.
DR HOGENOM; CLU_051859_0_0_1; -.
DR OrthoDB; 5405601at2759; -.
DR BioGRID-ORCS; 57751; 0 hits in 62 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000026171; Expressed in retinal neural layer and 253 other cell types or tissues.
DR ExpressionAtlas; E9Q446; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR CDD; cd16470; RING-H2_RNF25; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039133; RNF25.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13198:SF4; E3 UBIQUITIN-PROTEIN LIGASE RNF25; 1.
DR PANTHER; PTHR13198; RING FINGER PROTEIN 25; 1.
DR Pfam; PF05773; RWD; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00591; RWD; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS50908; RWD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:E9Q446,
KW ECO:0007829|MaxQB:E9Q446};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 18..127
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT DOMAIN 134..198
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 268..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 51098 MW; 1EAEF81F895F3351 CRC64;
MAASASTAAG EEDWVLPSEV EVLESIYLDE LQVMKGNGRS PWEIFITLHP ATAEVQDSQF
VCFTLVLRIP VQYPHEVPQI SIRNPRGLSD EQIHKISQAL GHVAKEGLGT AMLYELIEKG
KEILTDNNIP HGQCVICLYG FQEKEAFTKT PCYHYFHCHC LARYIQHMEQ ELTTQEQEQE
RQHVVTKQAV GVQCPVCREP LVYDLASLKA APEPQQPMEL YQPSAESLRQ QEELKLLYQR
QQEKGGIIDL EAERNRYFIS LQQPPAALEP ESAVDVSREP QPPNALSAEQ STSLADQSTL
PTSLPMTTQY TYEKTSGAGP NQQRPGETQK SVLDPPRHGR GSWRQYDRRH PKGGECCTPK
GTSEIHELPP PEKPLKETVD LKAEPRNKGL TGHPQEKGPG SWQGPSARRT RDCARWERSK
NRTPGSCYPH LPRGQGAYRS GTRREPLGLE SEEGS
//
