ID E9Q449_MOUSE Unreviewed; 1615 AA.
AC E9Q449;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=DENN domain containing 4C {ECO:0000313|Ensembl:ENSMUSP00000039860.9};
GN Name=Dennd4c {ECO:0000313|Ensembl:ENSMUSP00000039860.9,
GN ECO:0000313|MGI:MGI:1914769};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000039860.9, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0007829|PubMed:19131326}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000039860.9, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000039860.9,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000039860.9}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000039860.9};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; E9Q449; -.
DR jPOST; E9Q449; -.
DR MaxQB; E9Q449; -.
DR ProteomicsDB; 359089; -.
DR Antibodypedia; 10280; 115 antibodies from 18 providers.
DR Ensembl; ENSMUST00000045512.15; ENSMUSP00000039860.9; ENSMUSG00000038024.18.
DR UCSC; uc033idc.1; mouse.
DR AGR; MGI:1914769; -.
DR MGI; MGI:1914769; Dennd4c.
DR VEuPathDB; HostDB:ENSMUSG00000038024; -.
DR GeneTree; ENSGT00940000158215; -.
DR HOGENOM; CLU_003074_0_0_1; -.
DR ChiTaRS; Dennd4c; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000038024; Expressed in stroma of bone marrow and 254 other cell types or tissues.
DR ExpressionAtlas; E9Q449; baseline and differential.
DR Genevisible; E9Q449; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Proteomics identification {ECO:0007829|EPD:E9Q449,
KW ECO:0007829|MaxQB:E9Q449};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 40..199
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 191..640
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 918..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1615 AA; 178674 MW; CEB717060F6F29FA CRC64;
MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RTDTNSIGPK APITDIAVII KSAGETVPEG
YTCVEATPSA LQANLNYGSL KSPELFLCYR RGRDKPPLTD IGVLYEGKER LMPGCEVIQA
TPYGRCANVN NSSTTSQRIF ITYRRAPPVR SQNSLAVTDI CVIITSKGET PPHTFCKVDK
NLNCGMWGSN VFLCYKKSVP ASNAIAYKAG LIFRYPEEDY ESFPLSPSVP LFCLPMGATI
ECWDPQIKYP LPVFSTFVLT GSSAEKVYGA AIQFYEPYSQ ERLTEKQLTQ LGLLTLVEKR
VVSKPINSNK CICLLSHWPF FEAFKNFLMF IYKVSVSGPH PLPIEKHISH FMQNIPFPSP
QRPRILIQLS VHDAFILSQP VSTPLPLSGA NFSSLLMNLG PENCATLLLL VLLESKILLH
SLRPAVLTGV AEAVVAMIFP FQWQCPYIPL CPLSLAGVLS APLPFIVGVD SRYFDLHDPP
QDVVCIDLDT NTLYVADERK NINWKQLPKR PCKSLLGTLR RLYQQLCSVH RKPQESSAIE
MTPIEADYSW QKKMTQLEME IQETFLRFMA SILKGYRSYL RPITEAPSNK ATAADSLFDR
QGFLKSRDRA YTKFYTLLSK TQIFIRFIEE CSFVSDKDTG LAFFDDCIEK LFPDKGVERT
EKVDLDSAED TRLIELDDSQ RSEHTVFIMP PEPPPDDGNN LSPQYSYTYF PRLDLKLFDS
PQKLKLCFNR HPPGSSITNS PALMAKRTKQ EIKTAHKLAK RCYTNPPQWA KYLFSHCYSL
WFICLPAYVR VSHPKVRALQ QAHDVLVKMR KTDVDPLDEV CYRVVMQLCG LWVNPVLAVR
VLFEMKTARI KPNAITYGYY NKVVLESPWP SSTRSGIFLW TKVRNVVHGL AQFRQPLKKT
GQKSQVFSIS APQNAACGSD GDTVSHGSVD SSNDANNGEH TVFVRDLISL DSIDNHSSTG
GQSDQGYGSK DELVKEGADG HAPEEHTPPE LTTTELHIEE ECDISAIVSK HLQPTPEPQS
PTEPPAWGSS IVKVPSGLFD TNNRTSTGST STVLFSTQAP VEDAVFSEVT NFKKNGDRGE
KKQKHFPERS CSFSSESRAG MLLKKSSLDL NSSEMAIMMG ADAKILTAAL TCPKTSPPHV
TRTHSFENVN CHLADSRTRM SEGTRDSEHR SSPVLEMLEE SQELLEPVVG DNVAETAAEM
TCNSLQSNSH SDQSRDTQAG AQDPVNKRSS SYATRKAIER EDVETGLDPL SLLATECVEK
TSDSEDKLFS PVISRNLADE IESYMNLKSP LGSKSCSMEL HGEGNQEPGS PAVFAHPLER
SSSLPSDRGP PARDSTETEK SSPAVSSSKT LTGRFKPQSP YRAYKDRSTS LSALVRSSPN
SSLGSVVNSL SGLKLDNILS GPKIDVLKSS MKQAATVASK MWVAVASAYS YSDDEEETNK
DYSFPAGLED HHIVGETLSP NTSVSGLVPS ELTQSNTSLG SSSSSGDVGK LQCPAGEVPF
SRNIKGQDFE KSDHGSSQNT SMSSIYQNCA MEVLMSSCSQ CRACGALVYD EEIMAGWTAD
DSNLNTTCPF CKSNFLPLLN VEFKDLRGSA RLVLCKLPWE VSALKTWRGW PLLCL
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