ID E9Q5W5_MOUSE Unreviewed; 2924 AA.
AC E9Q5W5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Zinc finger, ZZ-type with EF hand domain 1 {ECO:0000313|Ensembl:ENSMUSP00000130515.2};
GN Name=Zzef1 {ECO:0000313|Ensembl:ENSMUSP00000130515.2,
GN ECO:0000313|MGI:MGI:2444286};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130515.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0007829|PubMed:19131326}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000130515.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130515.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000130515.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130515.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; E9Q5W5; -.
DR SwissPalm; E9Q5W5; -.
DR jPOST; E9Q5W5; -.
DR MaxQB; E9Q5W5; -.
DR PeptideAtlas; E9Q5W5; -.
DR ProteomicsDB; 363169; -.
DR Antibodypedia; 23205; 46 antibodies from 9 providers.
DR Ensembl; ENSMUST00000172220.8; ENSMUSP00000130515.2; ENSMUSG00000055670.15.
DR AGR; MGI:2444286; -.
DR MGI; MGI:2444286; Zzef1.
DR VEuPathDB; HostDB:ENSMUSG00000055670; -.
DR GeneTree; ENSGT00940000155045; -.
DR HOGENOM; CLU_000703_0_0_1; -.
DR PhylomeDB; E9Q5W5; -.
DR ChiTaRS; Zzef1; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000055670; Expressed in rostral migratory stream and 225 other cell types or tissues.
DR ExpressionAtlas; E9Q5W5; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08667; APC10-ZZEF1; 1.
DR CDD; cd02249; ZZ; 1.
DR CDD; cd02343; ZZ_EF; 1.
DR Gene3D; 3.30.60.90; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR InterPro; IPR040099; ZZEF1.
DR InterPro; IPR047052; ZZEF1_APC10.
DR InterPro; IPR041986; ZZEF1_ZZ.
DR PANTHER; PTHR22772; NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22772:SF4; ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF00569; ZZ; 2.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM00291; ZnF_ZZ; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 2.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:E9Q5W5,
KW ECO:0007829|MaxQB:E9Q5W5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 111..146
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 226..405
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1776..1831
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 1825..1880
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2388..2418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2398..2418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2924 AA; 328269 MW; DC062FA9C8E944E8 CRC64;
MGNAPSNSSE DEAAAAGGEG WSPHQDWAAD SGTTPGPGPA AAVLPSAAAL LEPARLREAA
AALRPAPPCE SLVSRHHGAL LRWLEERLGR GEESVTLEQF RELLEARGAG CSGEQFEEAF
AQFDAEGDGT VDAENMLEAL KNSSGANLQG ELSHVIRQLQ ACSLVPGFID IFSESKEGLG
IHSSMILRFL HRNRISSMVI PYPMLDHCNN MCTMRSSVLK ESLDQLVQKE KESPGDLARS
PEMDKLKSVT KCYAYIETSS NPADIYRMTN GETSSYWQSD GSARSHWIRL KMKPDVVLRH
LSIAVAATDQ SYMPQQVTVA VGRSASDLQE VRDVHIPSNV TGYVTLLENA NISQLYVQIN
IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW SLLTSLVTAS METNPAFVQT
VLHNTQKALQ HMPPLSLSPG STDFSTFLSP NVLEEVDSFL IRITSCCSTP EVELTLLAFA
LARGSIAKVM SSLCTITDHL DTQYDASSLI SSMASVRQNL LLKYGKPLQL TLQACDVKGK
EDKSGPENLL VEPWTRDGFL TETGKTRAST IFSTGSDSAF QVTQIRIMVR RGGIGAQCGL
VFAYNSPSNK FHAEEHFKRF EKYDKWKLQE LRQFVKSRIG CSSDDLGEDD PIGWFELEEE
WDEADVKLQQ CRVAKFLMVK FLCTRQESAE RLGVQGLSIS GYLRPARAEA EQSILYAHCR
RDTENIHGAT LLLRTLQFIQ QLSHDLMQQK ESGLKHKSFL DFAGLDLQIF WKFYSKLKQN
RREECICAQT LLLKLLQSCF SVLQGDPQAA SEEEKPTAQR SEGIQAAKEL YTHLCNVVDK
PNGNSMPMEI LKQEVRNTLL NGAAIFFPDR QTRRSQLFTM MKSVTEHERK QSLQLTFHSL
CTYFSDKDPG GLLLLPEKSD LATMNTSEVL AVMNTLLSVA ARECELLMLN RSHGAVGSVL
FSLFWSVQGS LLSWCFLQLK STDAAAKELA MDLIEKYVGQ FLASMRVILE SLLSQYSGKT
IVEKLCNSVF SMAARQLVIF LLDFCTLDVS HCTLLREFST LTELLKKLCS DPEGGLSKLD
VETWQQEQPV VLHTWTKEST HNYENNCHEV SVFISPGATY FEVEFDERCE TEKRYDYLEF
TDSRGGKTRY DTKVGTYKWP KKVTFKDGPR LQFLFHSDSS NNEWGYKFTV TAYGLPDVAV
SWGLDLQLLV SRLMGRLASQ CMALKSVHQL GSNMAVSQAK LTSVLNSPLW KPVFRHQICP
ELELEASWPT HPHKDGKEVK NIPDDPCRHF LLDFAQSEPA QNFCGPYSEL FKGFIQACRK
QAPKTDIVAG STIDQAVNAT FAALVYRTPD LYEKLQKYVN SGGKIALTEE FSQVYSLADG
IRIWMLEMKQ KSLLSLGNDS EEKRGLEAAE VNPESLAKEC IQKSLLLLKF LPMSKSSKEN
CDKLETVDET DHLQPLDRRQ RTSSVVEEHF QGSASPTEAA TPAAGDRSPA LEIQPKLLPS
SGPCVAEVST AEEPSPPSTP TRRPPFTRGR LRLLSFRSME ETRPVPTVKE KYPVLKDVMD
FIKDQSLSHE SVVKVLSLRK AQGQSILEVL RIIQYCTESL GQPHCFHPPY ILFLLELLTC
QKDFTNYFGH LEGCGADLHR EIRDTYYQLV LFLVKAIKRF SSINDRSLLP ALSCVQTALL
HLLDMGWEPS DLAFFVDIQL PDLLMNMSQE NISVHDSVIS QWSEEDELAD AKQNSEWMDE
CQDGMFEAWY EKIAQEDPEK QRKMHMFIAR YCDLLNVDIS CDGCDEIAPW HRYRCLQCSD
MDLCKTCFLG GVKPEGHGDD HEMVNMEFTC DHCQGLIIGR RMNCNVCDDF DLCYGCYTAK
KYSYGHLPTH SITAHPMVTI RISDRQRLIQ PYIHNYSWLL FAALALYSAH LTSTEQVDGE
QLDPQARTNA ATLRSQCMQL VGDCLMKAHQ GKGLKALALL GVLPDGDSTS ENQALPVTVS
FQASEEQADA GLLVPCNGKR AADTEVRPLD YKQKKKAGED LSIVKDPSCQ TQVSDAPASA
HVPPGLPDAE HPEVSAQVLV EEKAITPNPE QVFAECSQKR ILGLLAAMLP PIKSGPTVPL
IDLEHVLPLM FQVVISNAGH LNETYHLTLG LLGQLIIRLQ PAEVDAAVMK VLSAKHNLRV
GLDWACSMAE ILRSLNNAPL WRDVIATFTD HCIKQLPFQL KHTNIFTLLV LVGFPQVLCV
GTRCVYMDNA NEPHNVIILK HFTEKNRAVI VDVKTRKRKT VKDYQLVQKG GGQECGTSQS
QLSQYSQHFA FIASHLLQTS MDSHCPEAVE ATWVLSLALK GLYKTLKAHG FEETHATFLQ
TDLLKLLVKK CSKGTGFSKT WLLRDLEILS IMLYSSKKEI NTLAEHGDLE LDERGDQEEE
LDRPVSSPGE AEQKKLDPLE NLDEPTRICF LMAHDALNAP LHILRAIYEL QMKKTDSFFL
EVQKRFDGDE LTTDERIRSL AQRWQPSRSL RLEEQSAKAV DTDMIILPCL SRPARSDQAT
PESNPVTQKL ISSTESELQQ SYAKQRRSKS AALLHKELNC KSKRAIRDYL FRVNEATSVL
YARHVLASLL AEWPGHVPVS EDILELSGPA HMTYILDMFM QLEEKHQWEK ILQKVLQGCR
ENMLGTMALA ACQFMEEPGM EVQVRESKHP YNNNTSFEDK VHIPGAIYLS IKFDPQCNTE
EGCDELAMSS SSDFQQDRHN FSGSQQKWKD FELPGDTLYY RFTSDMSNTE WGYRFTVTAG
HLGRFQTGFE ILKQMLSEER VVPHLALGKI WEWLVGVACR QTGHQRLKAI HLLLRIVQCC
SHSDLCDLGL LKPLWQLFTH MEYGLFEDVT QPGILLPLHR ALTELFFVTE NRAQELGLLQ
EYLLALTTED HLLRCAAQAL QNIAAISLAI NYPNKATRLW NVEC
//
